Modulation of humoral immune response by central administration of leucine-enkephalin: Effects of mu, delta and kappa opioid receptor antagonists
Нема приказа
Аутори
Radulović, JelenaMančev, Zorica
Stanojević, Stanislava
Vasiljević, T.
Kovačević-Jovanović, Vesna
Pešić, Gordana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The effect of leucine-enkephalin (Leu-Enk) on primary humoral immune response was investigated following intracerebroventricular (i.c.v.) administration of the peptide in-the rat. Leu-Enk stimulated plaque-forming cell (PFC) response in rats i.c.v. injected with 0.1 and 1 mu g/kg, whereas doses of 20 and 50 mu g/kg exerted immunosuppressive effects. I.c.v. treatment of rats with partial derivative opioid receptor antagonist ICI 174 864 and kappa opioid receptor antagonist nor-binaltorphimine (nor-BNI) blocked stimulation and suppression of PFC response induced by Leu-Enk, respectively. The mu opioid receptor antagonist beta-funaltrexamine (beta-FNA) reversed both immunomodulatory effects produced by Leu-Enk. Since beta-FNA alone had no effect on PFC response (unlike ICI 174 864 and nor-BNI), these data showed that central effects of Leu-Enk on PFC response were mediated by brain mu opioid receptors, and suggested a possible involvement of partial derivative and kappa opioid receptors.
Кључне речи:
leucine-enkephalin / mu opioid receptors / delta opioid receptors / kappa opioid receptors / plaque-forming cell response / central nervous systemИзвор:
Journal of Neuroimmunology, 1996, 65, 2, 155-161Издавач:
- Elsevier, Amsterdam
DOI: 10.1016/0165-5728(96)00017-3
ISSN: 0165-5728
PubMed: 8964897
WoS: A1996UU15700008
Scopus: 2-s2.0-0029890541
Институција/група
TorlakTY - JOUR AU - Radulović, Jelena AU - Mančev, Zorica AU - Stanojević, Stanislava AU - Vasiljević, T. AU - Kovačević-Jovanović, Vesna AU - Pešić, Gordana PY - 1996 UR - http://intor.torlakinstitut.com/handle/123456789/63 AB - The effect of leucine-enkephalin (Leu-Enk) on primary humoral immune response was investigated following intracerebroventricular (i.c.v.) administration of the peptide in-the rat. Leu-Enk stimulated plaque-forming cell (PFC) response in rats i.c.v. injected with 0.1 and 1 mu g/kg, whereas doses of 20 and 50 mu g/kg exerted immunosuppressive effects. I.c.v. treatment of rats with partial derivative opioid receptor antagonist ICI 174 864 and kappa opioid receptor antagonist nor-binaltorphimine (nor-BNI) blocked stimulation and suppression of PFC response induced by Leu-Enk, respectively. The mu opioid receptor antagonist beta-funaltrexamine (beta-FNA) reversed both immunomodulatory effects produced by Leu-Enk. Since beta-FNA alone had no effect on PFC response (unlike ICI 174 864 and nor-BNI), these data showed that central effects of Leu-Enk on PFC response were mediated by brain mu opioid receptors, and suggested a possible involvement of partial derivative and kappa opioid receptors. PB - Elsevier, Amsterdam T2 - Journal of Neuroimmunology T1 - Modulation of humoral immune response by central administration of leucine-enkephalin: Effects of mu, delta and kappa opioid receptor antagonists EP - 161 IS - 2 SP - 155 VL - 65 DO - 10.1016/0165-5728(96)00017-3 UR - https://hdl.handle.net/21.15107/rcub_intor_63 ER -
@article{ author = "Radulović, Jelena and Mančev, Zorica and Stanojević, Stanislava and Vasiljević, T. and Kovačević-Jovanović, Vesna and Pešić, Gordana", year = "1996", abstract = "The effect of leucine-enkephalin (Leu-Enk) on primary humoral immune response was investigated following intracerebroventricular (i.c.v.) administration of the peptide in-the rat. Leu-Enk stimulated plaque-forming cell (PFC) response in rats i.c.v. injected with 0.1 and 1 mu g/kg, whereas doses of 20 and 50 mu g/kg exerted immunosuppressive effects. I.c.v. treatment of rats with partial derivative opioid receptor antagonist ICI 174 864 and kappa opioid receptor antagonist nor-binaltorphimine (nor-BNI) blocked stimulation and suppression of PFC response induced by Leu-Enk, respectively. The mu opioid receptor antagonist beta-funaltrexamine (beta-FNA) reversed both immunomodulatory effects produced by Leu-Enk. Since beta-FNA alone had no effect on PFC response (unlike ICI 174 864 and nor-BNI), these data showed that central effects of Leu-Enk on PFC response were mediated by brain mu opioid receptors, and suggested a possible involvement of partial derivative and kappa opioid receptors.", publisher = "Elsevier, Amsterdam", journal = "Journal of Neuroimmunology", title = "Modulation of humoral immune response by central administration of leucine-enkephalin: Effects of mu, delta and kappa opioid receptor antagonists", pages = "161-155", number = "2", volume = "65", doi = "10.1016/0165-5728(96)00017-3", url = "https://hdl.handle.net/21.15107/rcub_intor_63" }
Radulović, J., Mančev, Z., Stanojević, S., Vasiljević, T., Kovačević-Jovanović, V.,& Pešić, G.. (1996). Modulation of humoral immune response by central administration of leucine-enkephalin: Effects of mu, delta and kappa opioid receptor antagonists. in Journal of Neuroimmunology Elsevier, Amsterdam., 65(2), 155-161. https://doi.org/10.1016/0165-5728(96)00017-3 https://hdl.handle.net/21.15107/rcub_intor_63
Radulović J, Mančev Z, Stanojević S, Vasiljević T, Kovačević-Jovanović V, Pešić G. Modulation of humoral immune response by central administration of leucine-enkephalin: Effects of mu, delta and kappa opioid receptor antagonists. in Journal of Neuroimmunology. 1996;65(2):155-161. doi:10.1016/0165-5728(96)00017-3 https://hdl.handle.net/21.15107/rcub_intor_63 .
Radulović, Jelena, Mančev, Zorica, Stanojević, Stanislava, Vasiljević, T., Kovačević-Jovanović, Vesna, Pešić, Gordana, "Modulation of humoral immune response by central administration of leucine-enkephalin: Effects of mu, delta and kappa opioid receptor antagonists" in Journal of Neuroimmunology, 65, no. 2 (1996):155-161, https://doi.org/10.1016/0165-5728(96)00017-3 ., https://hdl.handle.net/21.15107/rcub_intor_63 .