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Modulation of humoral immune response by central administration of leucine-enkephalin: Effects of mu, delta and kappa opioid receptor antagonists
dc.creator | Radulović, Jelena | |
dc.creator | Mančev, Zorica | |
dc.creator | Stanojević, Stanislava | |
dc.creator | Vasiljević, T. | |
dc.creator | Kovačević-Jovanović, Vesna | |
dc.creator | Pešić, Gordana | |
dc.date.accessioned | 2021-02-18T10:19:01Z | |
dc.date.available | 2021-02-18T10:19:01Z | |
dc.date.issued | 1996 | |
dc.identifier.issn | 0165-5728 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/63 | |
dc.description.abstract | The effect of leucine-enkephalin (Leu-Enk) on primary humoral immune response was investigated following intracerebroventricular (i.c.v.) administration of the peptide in-the rat. Leu-Enk stimulated plaque-forming cell (PFC) response in rats i.c.v. injected with 0.1 and 1 mu g/kg, whereas doses of 20 and 50 mu g/kg exerted immunosuppressive effects. I.c.v. treatment of rats with partial derivative opioid receptor antagonist ICI 174 864 and kappa opioid receptor antagonist nor-binaltorphimine (nor-BNI) blocked stimulation and suppression of PFC response induced by Leu-Enk, respectively. The mu opioid receptor antagonist beta-funaltrexamine (beta-FNA) reversed both immunomodulatory effects produced by Leu-Enk. Since beta-FNA alone had no effect on PFC response (unlike ICI 174 864 and nor-BNI), these data showed that central effects of Leu-Enk on PFC response were mediated by brain mu opioid receptors, and suggested a possible involvement of partial derivative and kappa opioid receptors. | en |
dc.publisher | Elsevier, Amsterdam | |
dc.rights | restrictedAccess | |
dc.source | Journal of Neuroimmunology | |
dc.subject | leucine-enkephalin | en |
dc.subject | mu opioid receptors | en |
dc.subject | delta opioid receptors | en |
dc.subject | kappa opioid receptors | en |
dc.subject | plaque-forming cell response | en |
dc.subject | central nervous system | en |
dc.title | Modulation of humoral immune response by central administration of leucine-enkephalin: Effects of mu, delta and kappa opioid receptor antagonists | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 161 | |
dc.citation.issue | 2 | |
dc.citation.other | 65(2): 155-161 | |
dc.citation.spage | 155 | |
dc.citation.volume | 65 | |
dc.identifier.doi | 10.1016/0165-5728(96)00017-3 | |
dc.identifier.pmid | 8964897 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_intor_63 | |
dc.identifier.scopus | 2-s2.0-0029890541 | |
dc.identifier.wos | A1996UU15700008 | |
dc.type.version | publishedVersion |
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