@conference{
author = "Kuštrimović, Nataša and Mitić, Katarina and Kovačević-Jovanović, Vesna and Miletić, Tatjana and Vujić, Vesna and Dimitrijević, Mirjana and Stanojević, Stanislava",
year = "2008",
abstract = "Our previous study revealed that rats of Dark Agouti
(DA) strain developed more pronounced inflammatory
paw edema upon intraplantar (i.pl.) administration
of 50 Bl of Concanavalin A (Con A, 400 Bg per paw)
than rats of Albino Oxford (AO) strain. The aim of the
present study was to pharmacologically define Con Ainduced paw edema and to investigate contribution of
immune- and neurally-derived mediators of inflammation to the differences observed between these rat
strains. Seven months old male DA and AO rats were
i.pl. treated with 100 Bg of antagonists specific for
different receptors: opiod (naloxone), beta and alpha
adrenergic (propranolol and phentolamine, respectively), histamine H1 and H2 (chloropyramine and
ranitidine, respectively), 5-hydroxytryptamine 5HT3
(granisetron), or calcium antagonist verapamil. Thirty
minutes later rats were i.pl. treated with 400 Bg of Con
A. Intensity of inflammation was measured by the diameter of tarso-metatarsal joints with nonius before
and 3, 6, 9, 12 and 24h after injection of Con A. Results
revealed that naloxone and granisetron suppressed development of inflammatory edema in both rat strains,
confirming involvement of opioid and 5HT3 receptors
in Con A-induced inflammation in DA and AO rats. In
contrast, propranolol, phentolamine, chloropyramine,
ranitidine and verapamil oppositelly affected Con Ainduced inflammation in DA and AO rats. It could be
concluded that difference in the expression and/or
regulation of mediators of inflammation, especially
those acting via adrenergic and histamine receptors,
as well as calcium ions, in the subcutaneous tissue
of DA and AO rats, contribute to the differences in
the inflammatory response between these rat strains.
(Supported by Ministry of Science, Belgrade, Serbia,
Grant No145049)",
publisher = "Sciendo",
journal = "Serbian Journal of Experimental and Clinical Research",
title = "Pharmacological characterization of the concanavalin A-induced paw edema in two inbred rat strains",
number = "Supplement 1",
pages = "95",
volume = "9",
url = "https://hdl.handle.net/21.15107/rcub_intor_972"
}