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Stress applied during primary immunization affects the secondary humoral immune response in the rat: Involvement of opioid peptides

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Authors
Stanojević, Stanislava
Dimitrijević, Mirjana
Kovačević-Jovanović, Vesna
Miletić, Tatjana
Vujić, Vesna
Radulović, Jelena
Article (Published version)
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Abstract
The effect of unpredictable, inescapable and uncontrollable electric tail shocks (ES) on the humoral immune response to bovine serum albumin (BSA) was investigated in the rat. Contributions of the procedures that accompany shock delivery, such as witnessing the ES procedure (stress witnessing, SW) and exposure to the apparatus for shock delivery (apparatus control, AC) to the changes in specific immunity induced by ES were also tested. All procedures were applied during primary and/or secondary immunization. It was demonstrated that exposure to ES during primary immunization with BSA significantly suppressed specific anti-BSA antibody production after secondary and tertiary immunization with the same antigen. Exposure to the SW procedure during primary immunization with BSA enhanced the specific antibody level after secondary immunization, while exposure to the apparatus alone did not influence the development of either the primary or secondary humoral immune response to BSA. Both ES-i...nduced suppression and SW-induced potentiation of the humoral immune response were partially inhibited by prior treatment with the opioid receptor antagonist naloxone. Additionally, treatments with the opioid peptides methionine- and leucine-enkephalin decreased anti-BSA antibody level, mimicking to some extent the effects of ES. It is suggested that ES and endogenous opioid peptides had long-term effects on humoral immunity through mechanisms involving immunologic memory.

Keywords:
antibodies / apparatus control / electric shock stress / opioid peptides / stress witnessing
Source:
Stress-The International Journal on the Biology of Stress, 2003, 6, 4, 247-258
Publisher:
  • Taylor & Francis Ltd, Abingdon

DOI: 10.1080/1025389032000114515

ISSN: 1025-3890

PubMed: 14660057

WoS: 000188356000002

Scopus: 2-s2.0-1642556841
[ Google Scholar ]
7
7
URI
http://intor.torlakinstitut.com/handle/123456789/165
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Torlak
TY  - JOUR
AU  - Stanojević, Stanislava
AU  - Dimitrijević, Mirjana
AU  - Kovačević-Jovanović, Vesna
AU  - Miletić, Tatjana
AU  - Vujić, Vesna
AU  - Radulović, Jelena
PY  - 2003
UR  - http://intor.torlakinstitut.com/handle/123456789/165
AB  - The effect of unpredictable, inescapable and uncontrollable electric tail shocks (ES) on the humoral immune response to bovine serum albumin (BSA) was investigated in the rat. Contributions of the procedures that accompany shock delivery, such as witnessing the ES procedure (stress witnessing, SW) and exposure to the apparatus for shock delivery (apparatus control, AC) to the changes in specific immunity induced by ES were also tested. All procedures were applied during primary and/or secondary immunization. It was demonstrated that exposure to ES during primary immunization with BSA significantly suppressed specific anti-BSA antibody production after secondary and tertiary immunization with the same antigen. Exposure to the SW procedure during primary immunization with BSA enhanced the specific antibody level after secondary immunization, while exposure to the apparatus alone did not influence the development of either the primary or secondary humoral immune response to BSA. Both ES-induced suppression and SW-induced potentiation of the humoral immune response were partially inhibited by prior treatment with the opioid receptor antagonist naloxone. Additionally, treatments with the opioid peptides methionine- and leucine-enkephalin decreased anti-BSA antibody level, mimicking to some extent the effects of ES. It is suggested that ES and endogenous opioid peptides had long-term effects on humoral immunity through mechanisms involving immunologic memory.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Stress-The International Journal on the Biology of Stress
T1  - Stress applied during primary immunization affects the secondary humoral immune response in the rat: Involvement of opioid peptides
EP  - 258
IS  - 4
SP  - 247
VL  - 6
DO  - 10.1080/1025389032000114515
UR  - conv_145
ER  - 
@article{
author = "Stanojević, Stanislava and Dimitrijević, Mirjana and Kovačević-Jovanović, Vesna and Miletić, Tatjana and Vujić, Vesna and Radulović, Jelena",
year = "2003",
abstract = "The effect of unpredictable, inescapable and uncontrollable electric tail shocks (ES) on the humoral immune response to bovine serum albumin (BSA) was investigated in the rat. Contributions of the procedures that accompany shock delivery, such as witnessing the ES procedure (stress witnessing, SW) and exposure to the apparatus for shock delivery (apparatus control, AC) to the changes in specific immunity induced by ES were also tested. All procedures were applied during primary and/or secondary immunization. It was demonstrated that exposure to ES during primary immunization with BSA significantly suppressed specific anti-BSA antibody production after secondary and tertiary immunization with the same antigen. Exposure to the SW procedure during primary immunization with BSA enhanced the specific antibody level after secondary immunization, while exposure to the apparatus alone did not influence the development of either the primary or secondary humoral immune response to BSA. Both ES-induced suppression and SW-induced potentiation of the humoral immune response were partially inhibited by prior treatment with the opioid receptor antagonist naloxone. Additionally, treatments with the opioid peptides methionine- and leucine-enkephalin decreased anti-BSA antibody level, mimicking to some extent the effects of ES. It is suggested that ES and endogenous opioid peptides had long-term effects on humoral immunity through mechanisms involving immunologic memory.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Stress-The International Journal on the Biology of Stress",
title = "Stress applied during primary immunization affects the secondary humoral immune response in the rat: Involvement of opioid peptides",
pages = "258-247",
number = "4",
volume = "6",
doi = "10.1080/1025389032000114515",
url = "conv_145"
}
Stanojević, S., Dimitrijević, M., Kovačević-Jovanović, V., Miletić, T., Vujić, V.,& Radulović, J.. (2003). Stress applied during primary immunization affects the secondary humoral immune response in the rat: Involvement of opioid peptides. in Stress-The International Journal on the Biology of Stress
Taylor & Francis Ltd, Abingdon., 6(4), 247-258.
https://doi.org/10.1080/1025389032000114515
conv_145
Stanojević S, Dimitrijević M, Kovačević-Jovanović V, Miletić T, Vujić V, Radulović J. Stress applied during primary immunization affects the secondary humoral immune response in the rat: Involvement of opioid peptides. in Stress-The International Journal on the Biology of Stress. 2003;6(4):247-258.
doi:10.1080/1025389032000114515
conv_145 .
Stanojević, Stanislava, Dimitrijević, Mirjana, Kovačević-Jovanović, Vesna, Miletić, Tatjana, Vujić, Vesna, Radulović, Jelena, "Stress applied during primary immunization affects the secondary humoral immune response in the rat: Involvement of opioid peptides" in Stress-The International Journal on the Biology of Stress, 6, no. 4 (2003):247-258,
https://doi.org/10.1080/1025389032000114515 .,
conv_145 .

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