Reactive oxygen species (ROS), but not nitric oxide (NO), contribute to strain differences in the susceptibility to experimental arthritis in rats
Само за регистроване кориснике
2007
Аутори
Miletić, TatjanaKovačević-Jovanović, Vesna
Vujić, Vesna
Stanojević, Stanislava
Mitić, Katarina
Lazarević-Macanović, Miriana
Dimitrijević, Mirjana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
There is extensive evidence for the critical role of reactive oxygen species (ROS) and nitric oxide (NO) produced by phagocytes in development of inflammatory processes and pathogenesis of numerous diseases, including rheumatoid arthritis (RA). Apart from their function as mediators of inflammation and tissue damage, recent research supports their role as signaling and regulatory molecules. In the present study we have investigated the production of ROS and NO over the course of adjuvant arthritis (AA) and oil-induced arthritis (OIA), by resident peritoneal macrophages of two rat strains: Dark Agouti (DA), susceptible, and Albino Oxford (AO), resistant to induction of AA and OIA. We have compared levels of ROS and NO produced by susceptible vs. resistant rat strain, and investigated their relevancy for arthritis development and severity. In addition, we have stimulated macrophages in vitro with Mycobacterium bovis BCG, and two heat shock proteins (HSP): endogenous HSP47 and mycobacteri...al HSP71 (rnHSP71). Our results suggest a possible contribution of increased ROS production to arthritis resistance of AO rats. The ROS production in AO rats is potentiated by endogenous HSP47, but not with mycobacterial cell and mHSP71, suggesting HSP47 participates in AA control. We have found no fundamental relationship between the magnitude of NO production and AA and OIA susceptibility and severity, suggesting that NO has no effector role in AA and OIA. Our results advocate a regulatory type action of NO molecule aught be more significant in arthritis development. (c) 2006 Elsevier GmbH. All rights reserved.
Кључне речи:
BCG / experimental arthritis / HSP47 / MHSP71 / NO / rat strains / ROSИзвор:
Immunobiology, 2007, 212, 2, 95-105Издавач:
- Elsevier Gmbh, Munich
Финансирање / пројекти:
- Неуроендокрина модулација имунског одговора: улога симпато-адреномедуларног система (RS-MESTD-MPN2006-2010-145049)
DOI: 10.1016/j.imbio.2006.11.012
ISSN: 0171-2985
PubMed: 17336830
WoS: 000245314200003
Scopus: 2-s2.0-33847313733
Институција/група
TorlakTY - JOUR AU - Miletić, Tatjana AU - Kovačević-Jovanović, Vesna AU - Vujić, Vesna AU - Stanojević, Stanislava AU - Mitić, Katarina AU - Lazarević-Macanović, Miriana AU - Dimitrijević, Mirjana PY - 2007 UR - http://intor.torlakinstitut.com/handle/123456789/229 AB - There is extensive evidence for the critical role of reactive oxygen species (ROS) and nitric oxide (NO) produced by phagocytes in development of inflammatory processes and pathogenesis of numerous diseases, including rheumatoid arthritis (RA). Apart from their function as mediators of inflammation and tissue damage, recent research supports their role as signaling and regulatory molecules. In the present study we have investigated the production of ROS and NO over the course of adjuvant arthritis (AA) and oil-induced arthritis (OIA), by resident peritoneal macrophages of two rat strains: Dark Agouti (DA), susceptible, and Albino Oxford (AO), resistant to induction of AA and OIA. We have compared levels of ROS and NO produced by susceptible vs. resistant rat strain, and investigated their relevancy for arthritis development and severity. In addition, we have stimulated macrophages in vitro with Mycobacterium bovis BCG, and two heat shock proteins (HSP): endogenous HSP47 and mycobacterial HSP71 (rnHSP71). Our results suggest a possible contribution of increased ROS production to arthritis resistance of AO rats. The ROS production in AO rats is potentiated by endogenous HSP47, but not with mycobacterial cell and mHSP71, suggesting HSP47 participates in AA control. We have found no fundamental relationship between the magnitude of NO production and AA and OIA susceptibility and severity, suggesting that NO has no effector role in AA and OIA. Our results advocate a regulatory type action of NO molecule aught be more significant in arthritis development. (c) 2006 Elsevier GmbH. All rights reserved. PB - Elsevier Gmbh, Munich T2 - Immunobiology T1 - Reactive oxygen species (ROS), but not nitric oxide (NO), contribute to strain differences in the susceptibility to experimental arthritis in rats EP - 105 IS - 2 SP - 95 VL - 212 DO - 10.1016/j.imbio.2006.11.012 ER -
@article{ author = "Miletić, Tatjana and Kovačević-Jovanović, Vesna and Vujić, Vesna and Stanojević, Stanislava and Mitić, Katarina and Lazarević-Macanović, Miriana and Dimitrijević, Mirjana", year = "2007", abstract = "There is extensive evidence for the critical role of reactive oxygen species (ROS) and nitric oxide (NO) produced by phagocytes in development of inflammatory processes and pathogenesis of numerous diseases, including rheumatoid arthritis (RA). Apart from their function as mediators of inflammation and tissue damage, recent research supports their role as signaling and regulatory molecules. In the present study we have investigated the production of ROS and NO over the course of adjuvant arthritis (AA) and oil-induced arthritis (OIA), by resident peritoneal macrophages of two rat strains: Dark Agouti (DA), susceptible, and Albino Oxford (AO), resistant to induction of AA and OIA. We have compared levels of ROS and NO produced by susceptible vs. resistant rat strain, and investigated their relevancy for arthritis development and severity. In addition, we have stimulated macrophages in vitro with Mycobacterium bovis BCG, and two heat shock proteins (HSP): endogenous HSP47 and mycobacterial HSP71 (rnHSP71). Our results suggest a possible contribution of increased ROS production to arthritis resistance of AO rats. The ROS production in AO rats is potentiated by endogenous HSP47, but not with mycobacterial cell and mHSP71, suggesting HSP47 participates in AA control. We have found no fundamental relationship between the magnitude of NO production and AA and OIA susceptibility and severity, suggesting that NO has no effector role in AA and OIA. Our results advocate a regulatory type action of NO molecule aught be more significant in arthritis development. (c) 2006 Elsevier GmbH. All rights reserved.", publisher = "Elsevier Gmbh, Munich", journal = "Immunobiology", title = "Reactive oxygen species (ROS), but not nitric oxide (NO), contribute to strain differences in the susceptibility to experimental arthritis in rats", pages = "105-95", number = "2", volume = "212", doi = "10.1016/j.imbio.2006.11.012" }
Miletić, T., Kovačević-Jovanović, V., Vujić, V., Stanojević, S., Mitić, K., Lazarević-Macanović, M.,& Dimitrijević, M.. (2007). Reactive oxygen species (ROS), but not nitric oxide (NO), contribute to strain differences in the susceptibility to experimental arthritis in rats. in Immunobiology Elsevier Gmbh, Munich., 212(2), 95-105. https://doi.org/10.1016/j.imbio.2006.11.012
Miletić T, Kovačević-Jovanović V, Vujić V, Stanojević S, Mitić K, Lazarević-Macanović M, Dimitrijević M. Reactive oxygen species (ROS), but not nitric oxide (NO), contribute to strain differences in the susceptibility to experimental arthritis in rats. in Immunobiology. 2007;212(2):95-105. doi:10.1016/j.imbio.2006.11.012 .
Miletić, Tatjana, Kovačević-Jovanović, Vesna, Vujić, Vesna, Stanojević, Stanislava, Mitić, Katarina, Lazarević-Macanović, Miriana, Dimitrijević, Mirjana, "Reactive oxygen species (ROS), but not nitric oxide (NO), contribute to strain differences in the susceptibility to experimental arthritis in rats" in Immunobiology, 212, no. 2 (2007):95-105, https://doi.org/10.1016/j.imbio.2006.11.012 . .