Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease
Samo za registrovane korisnike
1997
Autori
Popović, M.Popović, N.
Jovanova-Nešić, Katica
Bokonjić, D.
Dobrić, Silva
Kostić, V.S.
Rosić, N.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The present study was performed to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.045, 0.060 and 0.075 mg/kg sc, 30 min before the tests) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc, 30 min before the tests), on two-way active avoidance (AA) learning (acquisition and performance) in nucleus basalis magnocellularis (NBM)-lesioned rats. Bilateral electrolytic lesions of NBM induced significant decrease of acquisition and performance of AA responses in rats. Physostigmine (0.060 mg/kg) significantly improved only acquisition of AA, while verapamil (2.5 and 5.0 mg/kg) significantly improved both type of AA behavior in NBM-lesioned rats. These results suggest that altered calcium homeostasis might play significant role in pathogenesis of experimental induced Alzheimer's disease (AD) and that administration of calcium antagonist such as verapamil might successfully ameliorate disturbances of learning and memory appeared after lesions ...of NBM.
Ključne reči:
Alzheimer's disease / nucleus basalis magnocellularis / two-way active avoidance / physostigmine / verapamil / ratsIzvor:
International Journal of Neuroscience, 1997, 90, 1-2, 87-97Izdavač:
- Taylor & Francis Ltd, Abingdon
DOI: 10.3109/00207459709000628
ISSN: 0020-7454
PubMed: 9285290
WoS: A1997XU98000008
Scopus: 2-s2.0-0031171068
Institucija/grupa
TorlakTY - JOUR AU - Popović, M. AU - Popović, N. AU - Jovanova-Nešić, Katica AU - Bokonjić, D. AU - Dobrić, Silva AU - Kostić, V.S. AU - Rosić, N. PY - 1997 UR - http://intor.torlakinstitut.com/handle/123456789/76 AB - The present study was performed to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.045, 0.060 and 0.075 mg/kg sc, 30 min before the tests) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc, 30 min before the tests), on two-way active avoidance (AA) learning (acquisition and performance) in nucleus basalis magnocellularis (NBM)-lesioned rats. Bilateral electrolytic lesions of NBM induced significant decrease of acquisition and performance of AA responses in rats. Physostigmine (0.060 mg/kg) significantly improved only acquisition of AA, while verapamil (2.5 and 5.0 mg/kg) significantly improved both type of AA behavior in NBM-lesioned rats. These results suggest that altered calcium homeostasis might play significant role in pathogenesis of experimental induced Alzheimer's disease (AD) and that administration of calcium antagonist such as verapamil might successfully ameliorate disturbances of learning and memory appeared after lesions of NBM. PB - Taylor & Francis Ltd, Abingdon T2 - International Journal of Neuroscience T1 - Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease EP - 97 IS - 1-2 SP - 87 VL - 90 DO - 10.3109/00207459709000628 ER -
@article{ author = "Popović, M. and Popović, N. and Jovanova-Nešić, Katica and Bokonjić, D. and Dobrić, Silva and Kostić, V.S. and Rosić, N.", year = "1997", abstract = "The present study was performed to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.045, 0.060 and 0.075 mg/kg sc, 30 min before the tests) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc, 30 min before the tests), on two-way active avoidance (AA) learning (acquisition and performance) in nucleus basalis magnocellularis (NBM)-lesioned rats. Bilateral electrolytic lesions of NBM induced significant decrease of acquisition and performance of AA responses in rats. Physostigmine (0.060 mg/kg) significantly improved only acquisition of AA, while verapamil (2.5 and 5.0 mg/kg) significantly improved both type of AA behavior in NBM-lesioned rats. These results suggest that altered calcium homeostasis might play significant role in pathogenesis of experimental induced Alzheimer's disease (AD) and that administration of calcium antagonist such as verapamil might successfully ameliorate disturbances of learning and memory appeared after lesions of NBM.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "International Journal of Neuroscience", title = "Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease", pages = "97-87", number = "1-2", volume = "90", doi = "10.3109/00207459709000628" }
Popović, M., Popović, N., Jovanova-Nešić, K., Bokonjić, D., Dobrić, S., Kostić, V.S.,& Rosić, N.. (1997). Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease. in International Journal of Neuroscience Taylor & Francis Ltd, Abingdon., 90(1-2), 87-97. https://doi.org/10.3109/00207459709000628
Popović M, Popović N, Jovanova-Nešić K, Bokonjić D, Dobrić S, Kostić V, Rosić N. Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease. in International Journal of Neuroscience. 1997;90(1-2):87-97. doi:10.3109/00207459709000628 .
Popović, M., Popović, N., Jovanova-Nešić, Katica, Bokonjić, D., Dobrić, Silva, Kostić, V.S., Rosić, N., "Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease" in International Journal of Neuroscience, 90, no. 1-2 (1997):87-97, https://doi.org/10.3109/00207459709000628 . .