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dc.creatorPopović, M.
dc.creatorPopović, N.
dc.creatorJovanova-Nešić, Katica
dc.creatorBokonjić, D.
dc.creatorDobrić, Silva
dc.creatorKostić, V.S.
dc.creatorRosić, N.
dc.date.accessioned2021-02-18T10:20:01Z
dc.date.available2021-02-18T10:20:01Z
dc.date.issued1997
dc.identifier.issn0020-7454
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/76
dc.description.abstractThe present study was performed to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.045, 0.060 and 0.075 mg/kg sc, 30 min before the tests) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc, 30 min before the tests), on two-way active avoidance (AA) learning (acquisition and performance) in nucleus basalis magnocellularis (NBM)-lesioned rats. Bilateral electrolytic lesions of NBM induced significant decrease of acquisition and performance of AA responses in rats. Physostigmine (0.060 mg/kg) significantly improved only acquisition of AA, while verapamil (2.5 and 5.0 mg/kg) significantly improved both type of AA behavior in NBM-lesioned rats. These results suggest that altered calcium homeostasis might play significant role in pathogenesis of experimental induced Alzheimer's disease (AD) and that administration of calcium antagonist such as verapamil might successfully ameliorate disturbances of learning and memory appeared after lesions of NBM.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Neuroscience
dc.subjectAlzheimer's diseaseen
dc.subjectnucleus basalis magnocellularisen
dc.subjecttwo-way active avoidanceen
dc.subjectphysostigmineen
dc.subjectverapamilen
dc.subjectratsen
dc.titleEffect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's diseaseen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage97
dc.citation.issue1-2
dc.citation.other90(1-2): 87-97
dc.citation.spage87
dc.citation.volume90
dc.identifier.doi10.3109/00207459709000628
dc.identifier.pmid9285290
dc.identifier.scopus2-s2.0-0031171068
dc.identifier.wosA1997XU98000008
dc.type.versionpublishedVersion


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