Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease
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1997
Authors
Popović, M.Popović, N.
Jovanova-Nešić, Katica
Bokonjić, D.
Dobrić, Silva
Kostić, V.S.
Rosić, N.
Article (Published version)
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The present study was performed to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.045, 0.060 and 0.075 mg/kg sc, 30 min before the tests) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc, 30 min before the tests), on two-way active avoidance (AA) learning (acquisition and performance) in nucleus basalis magnocellularis (NBM)-lesioned rats. Bilateral electrolytic lesions of NBM induced significant decrease of acquisition and performance of AA responses in rats. Physostigmine (0.060 mg/kg) significantly improved only acquisition of AA, while verapamil (2.5 and 5.0 mg/kg) significantly improved both type of AA behavior in NBM-lesioned rats. These results suggest that altered calcium homeostasis might play significant role in pathogenesis of experimental induced Alzheimer's disease (AD) and that administration of calcium antagonist such as verapamil might successfully ameliorate disturbances of learning and memory appeared after lesions ...of NBM.
Keywords:
Alzheimer's disease / nucleus basalis magnocellularis / two-way active avoidance / physostigmine / verapamil / ratsSource:
International Journal of Neuroscience, 1997, 90, 1-2, 87-97Publisher:
- Taylor & Francis Ltd, Abingdon
DOI: 10.3109/00207459709000628
ISSN: 0020-7454
PubMed: 9285290
WoS: A1997XU98000008
Scopus: 2-s2.0-0031171068
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TorlakTY - JOUR AU - Popović, M. AU - Popović, N. AU - Jovanova-Nešić, Katica AU - Bokonjić, D. AU - Dobrić, Silva AU - Kostić, V.S. AU - Rosić, N. PY - 1997 UR - http://intor.torlakinstitut.com/handle/123456789/76 AB - The present study was performed to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.045, 0.060 and 0.075 mg/kg sc, 30 min before the tests) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc, 30 min before the tests), on two-way active avoidance (AA) learning (acquisition and performance) in nucleus basalis magnocellularis (NBM)-lesioned rats. Bilateral electrolytic lesions of NBM induced significant decrease of acquisition and performance of AA responses in rats. Physostigmine (0.060 mg/kg) significantly improved only acquisition of AA, while verapamil (2.5 and 5.0 mg/kg) significantly improved both type of AA behavior in NBM-lesioned rats. These results suggest that altered calcium homeostasis might play significant role in pathogenesis of experimental induced Alzheimer's disease (AD) and that administration of calcium antagonist such as verapamil might successfully ameliorate disturbances of learning and memory appeared after lesions of NBM. PB - Taylor & Francis Ltd, Abingdon T2 - International Journal of Neuroscience T1 - Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease EP - 97 IS - 1-2 SP - 87 VL - 90 DO - 10.3109/00207459709000628 ER -
@article{ author = "Popović, M. and Popović, N. and Jovanova-Nešić, Katica and Bokonjić, D. and Dobrić, Silva and Kostić, V.S. and Rosić, N.", year = "1997", abstract = "The present study was performed to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.045, 0.060 and 0.075 mg/kg sc, 30 min before the tests) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc, 30 min before the tests), on two-way active avoidance (AA) learning (acquisition and performance) in nucleus basalis magnocellularis (NBM)-lesioned rats. Bilateral electrolytic lesions of NBM induced significant decrease of acquisition and performance of AA responses in rats. Physostigmine (0.060 mg/kg) significantly improved only acquisition of AA, while verapamil (2.5 and 5.0 mg/kg) significantly improved both type of AA behavior in NBM-lesioned rats. These results suggest that altered calcium homeostasis might play significant role in pathogenesis of experimental induced Alzheimer's disease (AD) and that administration of calcium antagonist such as verapamil might successfully ameliorate disturbances of learning and memory appeared after lesions of NBM.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "International Journal of Neuroscience", title = "Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease", pages = "97-87", number = "1-2", volume = "90", doi = "10.3109/00207459709000628" }
Popović, M., Popović, N., Jovanova-Nešić, K., Bokonjić, D., Dobrić, S., Kostić, V.S.,& Rosić, N.. (1997). Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease. in International Journal of Neuroscience Taylor & Francis Ltd, Abingdon., 90(1-2), 87-97. https://doi.org/10.3109/00207459709000628
Popović M, Popović N, Jovanova-Nešić K, Bokonjić D, Dobrić S, Kostić V, Rosić N. Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease. in International Journal of Neuroscience. 1997;90(1-2):87-97. doi:10.3109/00207459709000628 .
Popović, M., Popović, N., Jovanova-Nešić, Katica, Bokonjić, D., Dobrić, Silva, Kostić, V.S., Rosić, N., "Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease" in International Journal of Neuroscience, 90, no. 1-2 (1997):87-97, https://doi.org/10.3109/00207459709000628 . .