Prikaz osnovnih podataka o dokumentu
Strain specificities in cellular and molecular immunopathogenic mechanisms underlying development of experimental autoimmune encephalomyelitis in aged rats
dc.creator | Nacka-Aleksić, Mirjana | |
dc.creator | Stojić-Vukanić, Zorica | |
dc.creator | Pilipović, Ivan | |
dc.creator | Vujnović, Ivana | |
dc.creator | Bufan, Biljana | |
dc.creator | Dimitrijević, Mirjana | |
dc.creator | Leposavić, Gordana | |
dc.date.accessioned | 2021-02-18T10:48:35Z | |
dc.date.available | 2021-02-18T10:48:35Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0047-6374 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/490 | |
dc.description.abstract | To understand strain-specificities of immune system in aged rats and their immunopathological implications, CD4+T lymphocyte-mediated neuroinflammation in experimental autoimmune encephalomyelitis (EAE) was studied in two strains. Upon immunization for EAE, 22-24-month-old Albino Oxford (AO) rats developed milder neurological deficit of prolonged duration compared with their Dark Agouti (DA) counterparts. Consistently, they exhibited: (i) diminished neuroantigen-specific CD4+T lymphocyte generation in draining lymph nodes (reflecting lower density of high-affinity IL-2 receptor complex on their surface and higher CD4+FoxP3+CD25+regulatory cell frequency); (ii) less favorable spinal cord expression of CXCL12 and CCL2, and consequently diminished infiltration of neuroantigen-specific CD4+T lymphocytes, including highly pathogenic IL-17+IFN-gamma+ones, and inflammatory monocytes into the spinal cord and (iii) subsequently impaired CD4+T lymphocyte reactivation/survival and differentiation into highly pathogenic IL-17+cells (reflecting downregulated expression of IL-1 beta, IL-6 and IL-23/p19). On the other hand, when the neurological deficit reached maximum/plateau, in AO rat spinal cord was found lower CD4+FoxP3+CD25+ cell frequency followed by higher frequency of IL-10-producing CD8+T cells, which most likely also belong to regulatory T lymphocytes. Thus, the altered relation between regulatory T cell and effector CD4+T cell subsets was linked with persistence of mild neuroinflammation in AO rat EAE model. (C) 2017 Elsevier B.V. All rights reserved. | en |
dc.publisher | Elsevier Ireland Ltd, Clare | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS// | |
dc.rights | restrictedAccess | |
dc.source | Mechanisms of Ageing and Development | |
dc.subject | EAE | en |
dc.subject | Aged rats | en |
dc.subject | Rat strain differences | en |
dc.subject | IL-17+IFN-gamma plus T lymphocytes | en |
dc.subject | IL-10-producing T cells | en |
dc.title | Strain specificities in cellular and molecular immunopathogenic mechanisms underlying development of experimental autoimmune encephalomyelitis in aged rats | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 163 | |
dc.citation.other | 164: 146-163 | |
dc.citation.rank | M21 | |
dc.citation.spage | 146 | |
dc.citation.volume | 164 | |
dc.identifier.doi | 10.1016/j.mad.2017.03.001 | |
dc.identifier.pmid | 28284714 | |
dc.identifier.scopus | 2-s2.0-85015274375 | |
dc.identifier.wos | 000404502200018 | |
dc.type.version | publishedVersion |