Sexual diergism in antibody response to whole virus trivalent inactivated influenza vaccine in outbred mice
Само за регистроване кориснике
2015
Аутори
Živković, IrenaBufan, Biljana
Petrušić, Vladimir
Minić, Rajna
Arsenović-Ranin, Nevena
Petrović, Raisa
Leposavić, Gordana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
An outbred mouse model was used to determine if antibody response to immunization with whole-virus trivalent inactivated influenza vaccine (TIV) differs between the sexes. The antibody response was examined one (serum titer of IgM antibodies), and three and six weeks post-immunization (serum titer of neutralizing and total IgG antibodies and IgG subclass profile). Compared with male in female mice was found (i) the more robust IgM response against all influenza strains included in TIV and (ii) more vigorous neutralizing antibody and total IgG responses against H1N1 influenza virus at both the examined time points post-immunization. The total IgG antibody response against H3N2 and B influenza viruses was comparable between female and male mice three weeks post-immunization, but significantly greater in female mice six weeks post-immunization. The neutralizing antibody response against H3N2 and B influenza viruses did not significantly differ between sexes at both the examined points pos...t-immunization. Finally, three weeks post-immunization subclass profile of IgG specific to the influenza strains included in TIV differed between female and male mice, reflecting the lower titer of IgG1 antibodies in female ones, so that IgG2a (contributing mainly to the total IgG) to IgG1 ratio in mice of this sex was shifted toward the former. In agreement with this shift, compared with male mice, Th1/Th2 balance in female mice was shifted toward Th1, as shown by ELISPOT. Collectively, the results showed influenza virus strain-dependent sexual dimorphism in the magnitude, dynamics and characteristics of antibody response in outbred mice immunized with TIV. (C) 2015 Elsevier Ltd. All rights reserved.
Кључне речи:
Sex differences / Trivalent inactivated influenza vaccine / Antibody response / Th1/Th2 balanceИзвор:
Vaccine, 2015, 33, 42, 5546-5552Издавач:
- Elsevier Sci Ltd, Oxford
Финансирање / пројекти:
- Пластичност имунског система током старења: имуномодулаторни потенцијал естрогена (RS-MESTD-Basic Research (BR or ON)-175050)
- Алергени, антитела, ензими и мали физиолошки значајни молекули: дизајн, структура, функција и значај (RS-MESTD-Basic Research (BR or ON)-172049)
DOI: 10.1016/j.vaccine.2015.09.006
ISSN: 0264-410X
PubMed: 26382601
WoS: 000364268500013
Scopus: 2-s2.0-84943451379
Институција/група
TorlakTY - JOUR AU - Živković, Irena AU - Bufan, Biljana AU - Petrušić, Vladimir AU - Minić, Rajna AU - Arsenović-Ranin, Nevena AU - Petrović, Raisa AU - Leposavić, Gordana PY - 2015 UR - http://intor.torlakinstitut.com/handle/123456789/432 AB - An outbred mouse model was used to determine if antibody response to immunization with whole-virus trivalent inactivated influenza vaccine (TIV) differs between the sexes. The antibody response was examined one (serum titer of IgM antibodies), and three and six weeks post-immunization (serum titer of neutralizing and total IgG antibodies and IgG subclass profile). Compared with male in female mice was found (i) the more robust IgM response against all influenza strains included in TIV and (ii) more vigorous neutralizing antibody and total IgG responses against H1N1 influenza virus at both the examined time points post-immunization. The total IgG antibody response against H3N2 and B influenza viruses was comparable between female and male mice three weeks post-immunization, but significantly greater in female mice six weeks post-immunization. The neutralizing antibody response against H3N2 and B influenza viruses did not significantly differ between sexes at both the examined points post-immunization. Finally, three weeks post-immunization subclass profile of IgG specific to the influenza strains included in TIV differed between female and male mice, reflecting the lower titer of IgG1 antibodies in female ones, so that IgG2a (contributing mainly to the total IgG) to IgG1 ratio in mice of this sex was shifted toward the former. In agreement with this shift, compared with male mice, Th1/Th2 balance in female mice was shifted toward Th1, as shown by ELISPOT. Collectively, the results showed influenza virus strain-dependent sexual dimorphism in the magnitude, dynamics and characteristics of antibody response in outbred mice immunized with TIV. (C) 2015 Elsevier Ltd. All rights reserved. PB - Elsevier Sci Ltd, Oxford T2 - Vaccine T1 - Sexual diergism in antibody response to whole virus trivalent inactivated influenza vaccine in outbred mice EP - 5552 IS - 42 SP - 5546 VL - 33 DO - 10.1016/j.vaccine.2015.09.006 ER -
@article{ author = "Živković, Irena and Bufan, Biljana and Petrušić, Vladimir and Minić, Rajna and Arsenović-Ranin, Nevena and Petrović, Raisa and Leposavić, Gordana", year = "2015", abstract = "An outbred mouse model was used to determine if antibody response to immunization with whole-virus trivalent inactivated influenza vaccine (TIV) differs between the sexes. The antibody response was examined one (serum titer of IgM antibodies), and three and six weeks post-immunization (serum titer of neutralizing and total IgG antibodies and IgG subclass profile). Compared with male in female mice was found (i) the more robust IgM response against all influenza strains included in TIV and (ii) more vigorous neutralizing antibody and total IgG responses against H1N1 influenza virus at both the examined time points post-immunization. The total IgG antibody response against H3N2 and B influenza viruses was comparable between female and male mice three weeks post-immunization, but significantly greater in female mice six weeks post-immunization. The neutralizing antibody response against H3N2 and B influenza viruses did not significantly differ between sexes at both the examined points post-immunization. Finally, three weeks post-immunization subclass profile of IgG specific to the influenza strains included in TIV differed between female and male mice, reflecting the lower titer of IgG1 antibodies in female ones, so that IgG2a (contributing mainly to the total IgG) to IgG1 ratio in mice of this sex was shifted toward the former. In agreement with this shift, compared with male mice, Th1/Th2 balance in female mice was shifted toward Th1, as shown by ELISPOT. Collectively, the results showed influenza virus strain-dependent sexual dimorphism in the magnitude, dynamics and characteristics of antibody response in outbred mice immunized with TIV. (C) 2015 Elsevier Ltd. All rights reserved.", publisher = "Elsevier Sci Ltd, Oxford", journal = "Vaccine", title = "Sexual diergism in antibody response to whole virus trivalent inactivated influenza vaccine in outbred mice", pages = "5552-5546", number = "42", volume = "33", doi = "10.1016/j.vaccine.2015.09.006" }
Živković, I., Bufan, B., Petrušić, V., Minić, R., Arsenović-Ranin, N., Petrović, R.,& Leposavić, G.. (2015). Sexual diergism in antibody response to whole virus trivalent inactivated influenza vaccine in outbred mice. in Vaccine Elsevier Sci Ltd, Oxford., 33(42), 5546-5552. https://doi.org/10.1016/j.vaccine.2015.09.006
Živković I, Bufan B, Petrušić V, Minić R, Arsenović-Ranin N, Petrović R, Leposavić G. Sexual diergism in antibody response to whole virus trivalent inactivated influenza vaccine in outbred mice. in Vaccine. 2015;33(42):5546-5552. doi:10.1016/j.vaccine.2015.09.006 .
Živković, Irena, Bufan, Biljana, Petrušić, Vladimir, Minić, Rajna, Arsenović-Ranin, Nevena, Petrović, Raisa, Leposavić, Gordana, "Sexual diergism in antibody response to whole virus trivalent inactivated influenza vaccine in outbred mice" in Vaccine, 33, no. 42 (2015):5546-5552, https://doi.org/10.1016/j.vaccine.2015.09.006 . .