dc.creator | Pilipović, Ivan | |
dc.creator | Radojević, Katarina | |
dc.creator | Perišić, Milica | |
dc.creator | Leposavić, Gordana | |
dc.date.accessioned | 2021-02-18T10:38:33Z | |
dc.date.available | 2021-02-18T10:38:33Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0077-8923 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/347 | |
dc.description.abstract | This paper highlights the multiple putative thymic and extrathymic points of intersection and interaction between glucocorticoids (GCs) and catecholamines (CAs)-the end-point mediators of the major routes of communication between the brain and the immune system-in the context of intricate thymic T cell-developmental tuning. More specifically, we discuss in detail findings indicating that adrenal GCs can influence thymopoiesis by adjusting directly and/or indirectly (through modulation of pituitary and local ACTH synthesis) not only thymic GC synthesis, in a cell type-specific manner, but also thymic CA bioavailability (via altering CA outflow from sympathetic nerve endings and local CA synthesis), beta and alpha(1)-adrenoceptor (AR) expression, and/or AR-mediated intracellular signal transduction in thymic cells. In addition, this short review points to GC-and CA-sensitive stages along the multistep T cell-developmental journey and the possible effects of altered GC, and consequently CA signaling, on thymopoietic efficiency. | en |
dc.publisher | Blackwell Science Publ, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS// | |
dc.rights | restrictedAccess | |
dc.source | Neuroimmunomodulation in Health and Disease I | |
dc.subject | glucocorticoids | en |
dc.subject | catecholamines | en |
dc.subject | beta-adrenergic receptors | en |
dc.subject | rat thymus | en |
dc.subject | T cell development | en |
dc.title | Glucocorticoid-catecholamine interplay within the composite thymopoietic regulatory network | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 41 | |
dc.citation.other | 1261: 34-41 | |
dc.citation.rank | M21 | |
dc.citation.spage | 34 | |
dc.citation.volume | 1261 | |
dc.identifier.doi | 10.1111/j.1749-6632.2012.06623.x | |
dc.identifier.pmid | 22823391 | |
dc.identifier.scopus | 2-s2.0-84864081722 | |
dc.identifier.wos | 000312537900006 | |
dc.type.version | publishedVersion | |