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Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children
dc.creator | Atanasković-Marković, Marina | |
dc.creator | Veličković, Tanja | |
dc.creator | Gavrović-Jankulović, Marija | |
dc.creator | Vučković, Olga | |
dc.creator | Nestorovic, Branimir | |
dc.date.accessioned | 2021-02-18T10:28:37Z | |
dc.date.available | 2021-02-18T10:28:37Z | |
dc.date.issued | 2005 | |
dc.identifier.issn | 0905-6157 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/203 | |
dc.description.abstract | Penicillins and cephalosporins are the most important betalactams inducing IgE-mediated reactions. The safety of administering cephalosporins to penicillin-allergic children is a particular problem, because cephalosporin allergenic determinants have not been properly identified. A study was undertaken to evaluate the frequency of anaphylactic reactions to cephalosporins and penicillins and their cross-reactivity in a pediatric population. A prospective survey was conducted in a group of 1170 children with suspected immediate allergic reactions to cephalosporins and/or penicillins, which were examined during a period of 8 yr. In vivo (skin tests and challenges) and in vitro tests (for specific IgE) were performed with standard concentration of penicillins and cephalosporins. When 1170 children with a clinical history of allergy to penicillins and/or cephalosporins were tested in vivo for immediate hypersensitivity to betalactams, 58.3% cases overall were found to be skin or challenge test positive. Among them, 94.4% patients were positive to penicillins and 35.3% to cephalosporins. The frequency of positive reactions in the in vivo testing was in the range from 36.4% to 88.1% for penicillins and from 0.3% to 29.2% for cephalosporins. However, 31.5% of the penicillin allergic children cross-reacted to some cephalosporin. If a child was allergic to a cephalosporin, the frequency of positive reactions to penicillin was 84.2%. The cross-reactivity between cephalosporins and penicillins varied between 0.3% and 23.9%. The cross-reactivity among different generations of cephalosporins varied between 0% and 68.8%, being the highest for first and second-generation cephalosporins and 0% for third generation cephalosporins. The frequency of immediate allergic reactions to cephalosporins is considerably lower compared to penicillins, and the degree of cross-reactivity between cephalosporins and penicillins depends on the generation of cephalosporins, being higher with earlier generation cephalosporins. The cross-reactivity among cephalosporins is lower compared to cross-reactivity between penicillins and cephalosporins. | en |
dc.publisher | Blackwell Munksgaard | |
dc.rights | restrictedAccess | |
dc.source | Pediatric Allergy and Immunology | |
dc.subject | Betalactams | en |
dc.subject | Cephalosporins | en |
dc.subject | Children | en |
dc.subject | Cross-Reactivity | en |
dc.subject | Drug allergy | en |
dc.subject | Immediate allergic reaction | en |
dc.subject | Penicillins | en |
dc.title | Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 347 | |
dc.citation.issue | 4 | |
dc.citation.other | 16(4): 341-347 | |
dc.citation.rank | M21 | |
dc.citation.spage | 341 | |
dc.citation.volume | 16 | |
dc.identifier.doi | 10.1111/j.1399-3038.2005.00280.x | |
dc.identifier.pmid | 15943598 | |
dc.identifier.scopus | 2-s2.0-21044449657 | |
dc.identifier.wos | 000229590200010 | |
dc.type.version | publishedVersion |