Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children
Само за регистроване кориснике
2005
Аутори
Atanasković-Marković, MarinaVeličković, Tanja
Gavrović-Jankulović, Marija
Vučković, Olga
Nestorovic, Branimir
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Penicillins and cephalosporins are the most important betalactams inducing IgE-mediated reactions. The safety of administering cephalosporins to penicillin-allergic children is a particular problem, because cephalosporin allergenic determinants have not been properly identified. A study was undertaken to evaluate the frequency of anaphylactic reactions to cephalosporins and penicillins and their cross-reactivity in a pediatric population. A prospective survey was conducted in a group of 1170 children with suspected immediate allergic reactions to cephalosporins and/or penicillins, which were examined during a period of 8 yr. In vivo (skin tests and challenges) and in vitro tests (for specific IgE) were performed with standard concentration of penicillins and cephalosporins. When 1170 children with a clinical history of allergy to penicillins and/or cephalosporins were tested in vivo for immediate hypersensitivity to betalactams, 58.3% cases overall were found to be skin or challenge te...st positive. Among them, 94.4% patients were positive to penicillins and 35.3% to cephalosporins. The frequency of positive reactions in the in vivo testing was in the range from 36.4% to 88.1% for penicillins and from 0.3% to 29.2% for cephalosporins. However, 31.5% of the penicillin allergic children cross-reacted to some cephalosporin. If a child was allergic to a cephalosporin, the frequency of positive reactions to penicillin was 84.2%. The cross-reactivity between cephalosporins and penicillins varied between 0.3% and 23.9%. The cross-reactivity among different generations of cephalosporins varied between 0% and 68.8%, being the highest for first and second-generation cephalosporins and 0% for third generation cephalosporins. The frequency of immediate allergic reactions to cephalosporins is considerably lower compared to penicillins, and the degree of cross-reactivity between cephalosporins and penicillins depends on the generation of cephalosporins, being higher with earlier generation cephalosporins. The cross-reactivity among cephalosporins is lower compared to cross-reactivity between penicillins and cephalosporins.
Кључне речи:
Betalactams / Cephalosporins / Children / Cross-Reactivity / Drug allergy / Immediate allergic reaction / PenicillinsИзвор:
Pediatric Allergy and Immunology, 2005, 16, 4, 341-347Издавач:
- Blackwell Munksgaard
DOI: 10.1111/j.1399-3038.2005.00280.x
ISSN: 0905-6157
PubMed: 15943598
WoS: 000229590200010
Scopus: 2-s2.0-21044449657
Институција/група
TorlakTY - JOUR AU - Atanasković-Marković, Marina AU - Veličković, Tanja AU - Gavrović-Jankulović, Marija AU - Vučković, Olga AU - Nestorovic, Branimir PY - 2005 UR - http://intor.torlakinstitut.com/handle/123456789/203 AB - Penicillins and cephalosporins are the most important betalactams inducing IgE-mediated reactions. The safety of administering cephalosporins to penicillin-allergic children is a particular problem, because cephalosporin allergenic determinants have not been properly identified. A study was undertaken to evaluate the frequency of anaphylactic reactions to cephalosporins and penicillins and their cross-reactivity in a pediatric population. A prospective survey was conducted in a group of 1170 children with suspected immediate allergic reactions to cephalosporins and/or penicillins, which were examined during a period of 8 yr. In vivo (skin tests and challenges) and in vitro tests (for specific IgE) were performed with standard concentration of penicillins and cephalosporins. When 1170 children with a clinical history of allergy to penicillins and/or cephalosporins were tested in vivo for immediate hypersensitivity to betalactams, 58.3% cases overall were found to be skin or challenge test positive. Among them, 94.4% patients were positive to penicillins and 35.3% to cephalosporins. The frequency of positive reactions in the in vivo testing was in the range from 36.4% to 88.1% for penicillins and from 0.3% to 29.2% for cephalosporins. However, 31.5% of the penicillin allergic children cross-reacted to some cephalosporin. If a child was allergic to a cephalosporin, the frequency of positive reactions to penicillin was 84.2%. The cross-reactivity between cephalosporins and penicillins varied between 0.3% and 23.9%. The cross-reactivity among different generations of cephalosporins varied between 0% and 68.8%, being the highest for first and second-generation cephalosporins and 0% for third generation cephalosporins. The frequency of immediate allergic reactions to cephalosporins is considerably lower compared to penicillins, and the degree of cross-reactivity between cephalosporins and penicillins depends on the generation of cephalosporins, being higher with earlier generation cephalosporins. The cross-reactivity among cephalosporins is lower compared to cross-reactivity between penicillins and cephalosporins. PB - Blackwell Munksgaard T2 - Pediatric Allergy and Immunology T1 - Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children EP - 347 IS - 4 SP - 341 VL - 16 DO - 10.1111/j.1399-3038.2005.00280.x ER -
@article{ author = "Atanasković-Marković, Marina and Veličković, Tanja and Gavrović-Jankulović, Marija and Vučković, Olga and Nestorovic, Branimir", year = "2005", abstract = "Penicillins and cephalosporins are the most important betalactams inducing IgE-mediated reactions. The safety of administering cephalosporins to penicillin-allergic children is a particular problem, because cephalosporin allergenic determinants have not been properly identified. A study was undertaken to evaluate the frequency of anaphylactic reactions to cephalosporins and penicillins and their cross-reactivity in a pediatric population. A prospective survey was conducted in a group of 1170 children with suspected immediate allergic reactions to cephalosporins and/or penicillins, which were examined during a period of 8 yr. In vivo (skin tests and challenges) and in vitro tests (for specific IgE) were performed with standard concentration of penicillins and cephalosporins. When 1170 children with a clinical history of allergy to penicillins and/or cephalosporins were tested in vivo for immediate hypersensitivity to betalactams, 58.3% cases overall were found to be skin or challenge test positive. Among them, 94.4% patients were positive to penicillins and 35.3% to cephalosporins. The frequency of positive reactions in the in vivo testing was in the range from 36.4% to 88.1% for penicillins and from 0.3% to 29.2% for cephalosporins. However, 31.5% of the penicillin allergic children cross-reacted to some cephalosporin. If a child was allergic to a cephalosporin, the frequency of positive reactions to penicillin was 84.2%. The cross-reactivity between cephalosporins and penicillins varied between 0.3% and 23.9%. The cross-reactivity among different generations of cephalosporins varied between 0% and 68.8%, being the highest for first and second-generation cephalosporins and 0% for third generation cephalosporins. The frequency of immediate allergic reactions to cephalosporins is considerably lower compared to penicillins, and the degree of cross-reactivity between cephalosporins and penicillins depends on the generation of cephalosporins, being higher with earlier generation cephalosporins. The cross-reactivity among cephalosporins is lower compared to cross-reactivity between penicillins and cephalosporins.", publisher = "Blackwell Munksgaard", journal = "Pediatric Allergy and Immunology", title = "Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children", pages = "347-341", number = "4", volume = "16", doi = "10.1111/j.1399-3038.2005.00280.x" }
Atanasković-Marković, M., Veličković, T., Gavrović-Jankulović, M., Vučković, O.,& Nestorovic, B.. (2005). Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children. in Pediatric Allergy and Immunology Blackwell Munksgaard., 16(4), 341-347. https://doi.org/10.1111/j.1399-3038.2005.00280.x
Atanasković-Marković M, Veličković T, Gavrović-Jankulović M, Vučković O, Nestorovic B. Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children. in Pediatric Allergy and Immunology. 2005;16(4):341-347. doi:10.1111/j.1399-3038.2005.00280.x .
Atanasković-Marković, Marina, Veličković, Tanja, Gavrović-Jankulović, Marija, Vučković, Olga, Nestorovic, Branimir, "Immediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children" in Pediatric Allergy and Immunology, 16, no. 4 (2005):341-347, https://doi.org/10.1111/j.1399-3038.2005.00280.x . .