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Alterations in thymopoiesis in intact and peripubertally orchidectomized adult rats of different age
dc.creator | Leposavić, Gordana | |
dc.creator | Pejčić-Karapetrović, Branka | |
dc.creator | Kosec, Duško | |
dc.date.accessioned | 2021-02-18T10:24:19Z | |
dc.date.available | 2021-02-18T10:24:19Z | |
dc.date.issued | 2002 | |
dc.identifier.issn | 0047-6374 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/142 | |
dc.description.abstract | In adult rats 3, 6 and 9 months post-orchidectomy performed at the age of 30 days the thymus weight, thymocyte yield and relative proportions of thymocyte subsets (delineated by expression of CD4/CD8 molecules and TCRalphabeta) were analyzed in order to elucidate a putative role of male gonadal hormones in the shaping of thymus size and intrathymic T cell Maturation, In 4-month-old control rats the thymus size and cellularity returned to the corresponding levels in 1-month-old rats, These levels were sustained during the following 6 months. In spite of that, the distribution of the main thymocyte subsets in these rats as Subjected to significant changes, probably due to an age-associated diminishing thymus ability to provide efficient T cell differentiation. The results added further v.,eight to a potential feedback regulatory role of CD4+8- cells in thymopoiesis. Furthermore. they revealed that the orchidectomy-induced (i) enlargement of the thymus size and enrichment of the thymic lymphoid cell content are of a limited duration and (ii) alterations in the relative proportion of thymocytes become quantitatively more pronounced with duration of the gonadal deprivation. Thus, the study also indicates that the age-associated changes in gonadal hormones may be, at least partly. responsible For the age-related reshaping a of the T cell maturation sequence, and hence for remodeling T cell dependent immune functions. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. | en |
dc.publisher | Elsevier Ireland Ltd, Clare | |
dc.rights | restrictedAccess | |
dc.source | Mechanisms of Ageing and Development | |
dc.subject | thymus | en |
dc.subject | T cell differentiation | en |
dc.subject | castration | en |
dc.subject | androgens | en |
dc.title | Alterations in thymopoiesis in intact and peripubertally orchidectomized adult rats of different age | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 411 | |
dc.citation.issue | 4 | |
dc.citation.other | 123(4): 401-411 | |
dc.citation.rank | M21 | |
dc.citation.spage | 401 | |
dc.citation.volume | 123 | |
dc.identifier.doi | 10.1016/S0047-6374(01)00399-2 | |
dc.identifier.pmid | 11744050 | |
dc.identifier.scopus | 2-s2.0-0036138232 | |
dc.identifier.wos | 000177125000013 | |
dc.type.version | publishedVersion |