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Age-associated changes in CD90 expression on thymocytes and in TCR-dependent stages of thymocyte maturation in male rats
(Pergamon-Elsevier Science Ltd, Oxford, 2006)
To elucidate the effects of ageing on T-cell-maturation, in 3- and 18-month-old rats, we analysed the expression of: (i) CD4/CD8/TCR alpha beta and (ii) Thy-1, which is supposed to be a regulator of TCR alpha beta signalling, ...
Age-related effect of peptide YY (PYY) on paw edema in the rat: The function of Y1 receptors on inflammatory cells
(Pergamon-Elsevier Science Ltd, Oxford, 2006)
It is well documented that neuropeptides participate in local inflammatory reaction and modulate functions of inflammatory cells. The aim of the study was to determine a link between in vivo and in vitro effects of NPY-related ...
Age-associated plasticity of alpha 1-adrenoceptor-mediated tuning of T-cell development
(Pergamon-Elsevier Science Ltd, Oxford, 2010)
Alpha(1)-adrenoceptors (alpha(1)-ARs) are involved in neuro-thymic and thymic intercellular communications, and consequently modulation of T-cell development. Ageing is associated with a number of changes in noradrenergic ...
Age-associated changes in rat immune system: Lessons learned from experimental autoimmune encephalomyelitis
(Pergamon-Elsevier Science Ltd, Oxford, 2014)
Aging is associated with the decline in immune response to infectious agents and tumors and increasing risk of autoimmunity, but the incidence of autoimmune diseases does not increase in the elderly. To elucidate the ...
The influence of aging and estradiol to progesterone ratio on rat macrophage phenotypic profile and NO and TNF-alpha production
(Pergamon-Elsevier Science Ltd, Oxford, 2013)
The phenotype and function of tissue macrophages substantially depend on the cellular milieu and biological effector molecules, such as steroid hormones, to which they are exposed. Furthermore, in female rats, aging is ...
Strain-dependent response to stimulation in middle-aged rat macrophages: A quest after a useful indicator of healthy aging
(Pergamon-Elsevier Science Ltd, Oxford, 2016)
Rats of Albino Oxford (AO) strain in our animal facility exhibit a longer average healthy life span than rats of Dark Agouit (DA) strain. Since chronic activation of macrophages contributes to chronic low level inflammation ...