Age-related effect of peptide YY (PYY) on paw edema in the rat: The function of Y1 receptors on inflammatory cells
Само за регистроване кориснике
2006
Аутори
Stanojević, StanislavaVujić, Vesna
Kovačević-Jovanović, Vesna
Mitić, Katarina
Kosec, Duško
von Hoersten, Stephan
Dimitrijević, Mirjana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
It is well documented that neuropeptides participate in local inflammatory reaction and modulate functions of inflammatory cells. The aim of the study was to determine a link between in vivo and in vitro effects of NPY-related peptides on inflammatory response with respect to ageing. Peptide YY (PYY) intraplantarly applied decreases concanavalin A-induced paw edema in 3 and 8 months, but not in 24 months old male rats of Albino Oxford strain. The use of NPY-related receptor-specific peptides and Y1 receptor antagonist revealed that anti-inflammatory effect of PYY is mediated via NPY Y1 receptors. PYY in vitro decreases adherence of macrophages from 8 months, but not from 3 and 24 months old rats and this effect is also mediated via NPY Y1 receptor. Additionally, PYY (10(-6) M) decreases NBT reduction in macrophages from 3 and 8 months old rats, and suppresses NO production in cells from 24 months old rats, albeit regardless of absence of in vivo effect of PYY on inflammation in aged ra...ts. It is concluded that aged rats are less responsive to anti-inflammatory action of PYY compared to adult and young rats, and that ageing is associated with altered NPY Y1 receptor functioning. (c) 2006 Elsevier Inc. All rights reserved.
Кључне речи:
inflammation / macrophages / peptide YY (PYY) / Y1 receptor / Albino Oxford ratsИзвор:
Experimental Gerontology, 2006, 41, 8, 793-799Издавач:
- Pergamon-Elsevier Science Ltd, Oxford
Финансирање / пројекти:
- Неуроендокрина модулација имунског одговора: улога симпато-адреномедуларног система (RS-MESTD-MPN2006-2010-145049)
DOI: 10.1016/j.exger.2006.05.012
ISSN: 0531-5565
PubMed: 16809015
WoS: 000240372700011
Scopus: 2-s2.0-33747094756
Институција/група
TorlakTY - JOUR AU - Stanojević, Stanislava AU - Vujić, Vesna AU - Kovačević-Jovanović, Vesna AU - Mitić, Katarina AU - Kosec, Duško AU - von Hoersten, Stephan AU - Dimitrijević, Mirjana PY - 2006 UR - http://intor.torlakinstitut.com/handle/123456789/211 AB - It is well documented that neuropeptides participate in local inflammatory reaction and modulate functions of inflammatory cells. The aim of the study was to determine a link between in vivo and in vitro effects of NPY-related peptides on inflammatory response with respect to ageing. Peptide YY (PYY) intraplantarly applied decreases concanavalin A-induced paw edema in 3 and 8 months, but not in 24 months old male rats of Albino Oxford strain. The use of NPY-related receptor-specific peptides and Y1 receptor antagonist revealed that anti-inflammatory effect of PYY is mediated via NPY Y1 receptors. PYY in vitro decreases adherence of macrophages from 8 months, but not from 3 and 24 months old rats and this effect is also mediated via NPY Y1 receptor. Additionally, PYY (10(-6) M) decreases NBT reduction in macrophages from 3 and 8 months old rats, and suppresses NO production in cells from 24 months old rats, albeit regardless of absence of in vivo effect of PYY on inflammation in aged rats. It is concluded that aged rats are less responsive to anti-inflammatory action of PYY compared to adult and young rats, and that ageing is associated with altered NPY Y1 receptor functioning. (c) 2006 Elsevier Inc. All rights reserved. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Experimental Gerontology T1 - Age-related effect of peptide YY (PYY) on paw edema in the rat: The function of Y1 receptors on inflammatory cells EP - 799 IS - 8 SP - 793 VL - 41 DO - 10.1016/j.exger.2006.05.012 ER -
@article{ author = "Stanojević, Stanislava and Vujić, Vesna and Kovačević-Jovanović, Vesna and Mitić, Katarina and Kosec, Duško and von Hoersten, Stephan and Dimitrijević, Mirjana", year = "2006", abstract = "It is well documented that neuropeptides participate in local inflammatory reaction and modulate functions of inflammatory cells. The aim of the study was to determine a link between in vivo and in vitro effects of NPY-related peptides on inflammatory response with respect to ageing. Peptide YY (PYY) intraplantarly applied decreases concanavalin A-induced paw edema in 3 and 8 months, but not in 24 months old male rats of Albino Oxford strain. The use of NPY-related receptor-specific peptides and Y1 receptor antagonist revealed that anti-inflammatory effect of PYY is mediated via NPY Y1 receptors. PYY in vitro decreases adherence of macrophages from 8 months, but not from 3 and 24 months old rats and this effect is also mediated via NPY Y1 receptor. Additionally, PYY (10(-6) M) decreases NBT reduction in macrophages from 3 and 8 months old rats, and suppresses NO production in cells from 24 months old rats, albeit regardless of absence of in vivo effect of PYY on inflammation in aged rats. It is concluded that aged rats are less responsive to anti-inflammatory action of PYY compared to adult and young rats, and that ageing is associated with altered NPY Y1 receptor functioning. (c) 2006 Elsevier Inc. All rights reserved.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Experimental Gerontology", title = "Age-related effect of peptide YY (PYY) on paw edema in the rat: The function of Y1 receptors on inflammatory cells", pages = "799-793", number = "8", volume = "41", doi = "10.1016/j.exger.2006.05.012" }
Stanojević, S., Vujić, V., Kovačević-Jovanović, V., Mitić, K., Kosec, D., von Hoersten, S.,& Dimitrijević, M.. (2006). Age-related effect of peptide YY (PYY) on paw edema in the rat: The function of Y1 receptors on inflammatory cells. in Experimental Gerontology Pergamon-Elsevier Science Ltd, Oxford., 41(8), 793-799. https://doi.org/10.1016/j.exger.2006.05.012
Stanojević S, Vujić V, Kovačević-Jovanović V, Mitić K, Kosec D, von Hoersten S, Dimitrijević M. Age-related effect of peptide YY (PYY) on paw edema in the rat: The function of Y1 receptors on inflammatory cells. in Experimental Gerontology. 2006;41(8):793-799. doi:10.1016/j.exger.2006.05.012 .
Stanojević, Stanislava, Vujić, Vesna, Kovačević-Jovanović, Vesna, Mitić, Katarina, Kosec, Duško, von Hoersten, Stephan, Dimitrijević, Mirjana, "Age-related effect of peptide YY (PYY) on paw edema in the rat: The function of Y1 receptors on inflammatory cells" in Experimental Gerontology, 41, no. 8 (2006):793-799, https://doi.org/10.1016/j.exger.2006.05.012 . .