TY  - JOUR
AU  - Dimitrijević, Mirjana
AU  - Stanojević, Stanislava
AU  - Vujić, Vesna
AU  - Beck-Sickinger, A.
AU  - von Hoersten, Stephan
PY  - 2005
UR  - http://intor.torlakinstitut.com/handle/123456789/200
AB  - It is well documented that neuropeptide Y (NPY) exerts a wide range of biological functions through at least five NPY Y receptor subtypes (Y1-Y5), but its immunological effects only recently came into focus. Using NPY family pepticles and NPY-related receptor-specific peptides as well as Y1 and Y2 receptor antagonists, we have tested which NPY Y receptors are involved in NPY-induced modulation of rat peritoneal macrophage function in vitro. NPY and PYY increased oxidative burst in phorbol myristate acetate (PMA)-stimulated macrophages involving activation of protein kinase C (PKC), and decreased it in zymosan-stimulated cells resembling inhibition of signaling pathways subsequent to binding of zymosan particles for the iC3b fragment receptor on macrophages. The combined treatment with NPY and NPY Y receptor antagonists revealed that NPY-induced potentiation of oxidative burst in PMA-stimulated cells is mediated through Y1 and Y2 receptors, while NPY-induced suppression in zymosan-stimulated cells is mediated through Y2 receptors only. NPY-related peptides differently modulated macrophage function, confirming involvement of NPY Y2 receptor in both potentiation and suppression of oxidative burst in these cells. Additionally, it was shown that NPY Y5 receptor mediated suppression of oxidative burst in PMA- and zymosan-stimulated macrophages. Taken together, the present data reveal an NPY Y1 and Y2/Y5 receptor interaction in NPY-induced modulation of macrophage functions related to inflammation. (C) 2004 Elsevier B.V. All rights reserved.
PB  - Elsevier, Amsterdam
T2  - Regulatory Peptides
T1  - Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptors
EP  - 172
IS  - 1-3
SP  - 163
VL  - 124
DO  - 10.1016/j.regpep.2004.07.012
ER  - 

@article{
author = "Dimitrijević, Mirjana and Stanojević, Stanislava and Vujić, Vesna and Beck-Sickinger, A. and von Hoersten, Stephan",
year = "2005",
abstract = "It is well documented that neuropeptide Y (NPY) exerts a wide range of biological functions through at least five NPY Y receptor subtypes (Y1-Y5), but its immunological effects only recently came into focus. Using NPY family pepticles and NPY-related receptor-specific peptides as well as Y1 and Y2 receptor antagonists, we have tested which NPY Y receptors are involved in NPY-induced modulation of rat peritoneal macrophage function in vitro. NPY and PYY increased oxidative burst in phorbol myristate acetate (PMA)-stimulated macrophages involving activation of protein kinase C (PKC), and decreased it in zymosan-stimulated cells resembling inhibition of signaling pathways subsequent to binding of zymosan particles for the iC3b fragment receptor on macrophages. The combined treatment with NPY and NPY Y receptor antagonists revealed that NPY-induced potentiation of oxidative burst in PMA-stimulated cells is mediated through Y1 and Y2 receptors, while NPY-induced suppression in zymosan-stimulated cells is mediated through Y2 receptors only. NPY-related peptides differently modulated macrophage function, confirming involvement of NPY Y2 receptor in both potentiation and suppression of oxidative burst in these cells. Additionally, it was shown that NPY Y5 receptor mediated suppression of oxidative burst in PMA- and zymosan-stimulated macrophages. Taken together, the present data reveal an NPY Y1 and Y2/Y5 receptor interaction in NPY-induced modulation of macrophage functions related to inflammation. (C) 2004 Elsevier B.V. All rights reserved.",
publisher = "Elsevier, Amsterdam",
journal = "Regulatory Peptides",
title = "Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptors",
pages = "172-163",
number = "1-3",
volume = "124",
doi = "10.1016/j.regpep.2004.07.012"
}

Dimitrijević, M., Stanojević, S., Vujić, V., Beck-Sickinger, A.,& von Hoersten, S.. (2005). Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptors. in Regulatory Peptides
Elsevier, Amsterdam., 124(1-3), 163-172.
https://doi.org/10.1016/j.regpep.2004.07.012

Dimitrijević M, Stanojević S, Vujić V, Beck-Sickinger A, von Hoersten S. Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptors. in Regulatory Peptides. 2005;124(1-3):163-172.
doi:10.1016/j.regpep.2004.07.012 .

Dimitrijević, Mirjana, Stanojević, Stanislava, Vujić, Vesna, Beck-Sickinger, A., von Hoersten, Stephan, "Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptors" in Regulatory Peptides, 124, no. 1-3 (2005):163-172,
https://doi.org/10.1016/j.regpep.2004.07.012 . .

TY  - JOUR
AU  - Dimitrijević, Mirjana
AU  - Stanojević, Stanislava
AU  - Vujić, Vesna
AU  - Kovačević-Jovanović, Vesna
AU  - Beck-Sickinger, A.
AU  - Demuth, H.U.
AU  - von Hoersten, Stephan
PY  - 2002
UR  - http://intor.torlakinstitut.com/handle/123456789/153
AB  - Several lines of evidence suggest that neuropeptide Y (NPY) may exert regulatory effects in local inflammatory responses. Here, we show that intraplantarly (i.pl.) applied NPY, peptide YY (PYY), and an NPY Y5 receptor-selective agonist dose-dependently potentiate concanavalin A (Con A)-induced paw edema in the rat. The NPY Y1 receptor antagonist BIBO 3304 abolishes the pro-inflammatory action of both NPY and PYY while the dipeptidyl-peptidase IV (CD26) inhibitor Ile-thiazolidide exerted synergistic and potentiating effects in vivo. Taken together, the present data reveal an NPY Y1/Y5 receptor interplay and an involvement of CD26 in the NPY-induced potentiation of paw edema in the rat. (C) 2002 Elsevier Science B.V. All rights reserved.
PB  - Elsevier, Amsterdam
T2  - Journal of Neuroimmunology
T1  - Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPYY1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26)
EP  - 42
IS  - 1-2
SP  - 35
VL  - 129
DO  - 10.1016/S0165-5728(02)00173-X
ER  - 

@article{
author = "Dimitrijević, Mirjana and Stanojević, Stanislava and Vujić, Vesna and Kovačević-Jovanović, Vesna and Beck-Sickinger, A. and Demuth, H.U. and von Hoersten, Stephan",
year = "2002",
abstract = "Several lines of evidence suggest that neuropeptide Y (NPY) may exert regulatory effects in local inflammatory responses. Here, we show that intraplantarly (i.pl.) applied NPY, peptide YY (PYY), and an NPY Y5 receptor-selective agonist dose-dependently potentiate concanavalin A (Con A)-induced paw edema in the rat. The NPY Y1 receptor antagonist BIBO 3304 abolishes the pro-inflammatory action of both NPY and PYY while the dipeptidyl-peptidase IV (CD26) inhibitor Ile-thiazolidide exerted synergistic and potentiating effects in vivo. Taken together, the present data reveal an NPY Y1/Y5 receptor interplay and an involvement of CD26 in the NPY-induced potentiation of paw edema in the rat. (C) 2002 Elsevier Science B.V. All rights reserved.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Neuroimmunology",
title = "Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPYY1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26)",
pages = "42-35",
number = "1-2",
volume = "129",
doi = "10.1016/S0165-5728(02)00173-X"
}

Dimitrijević, M., Stanojević, S., Vujić, V., Kovačević-Jovanović, V., Beck-Sickinger, A., Demuth, H.U.,& von Hoersten, S.. (2002). Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPYY1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26). in Journal of Neuroimmunology
Elsevier, Amsterdam., 129(1-2), 35-42.
https://doi.org/10.1016/S0165-5728(02)00173-X

Dimitrijević M, Stanojević S, Vujić V, Kovačević-Jovanović V, Beck-Sickinger A, Demuth H, von Hoersten S. Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPYY1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26). in Journal of Neuroimmunology. 2002;129(1-2):35-42.
doi:10.1016/S0165-5728(02)00173-X .

Dimitrijević, Mirjana, Stanojević, Stanislava, Vujić, Vesna, Kovačević-Jovanović, Vesna, Beck-Sickinger, A., Demuth, H.U., von Hoersten, Stephan, "Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPYY1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26)" in Journal of Neuroimmunology, 129, no. 1-2 (2002):35-42,
https://doi.org/10.1016/S0165-5728(02)00173-X . .