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Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptors

Authorized Users Only
2005
Authors
Dimitrijević, Mirjana
Stanojević, Stanislava
Vujić, Vesna
Beck-Sickinger, A.
von Hoersten, Stephan
Article (Published version)
Metadata
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Abstract
It is well documented that neuropeptide Y (NPY) exerts a wide range of biological functions through at least five NPY Y receptor subtypes (Y1-Y5), but its immunological effects only recently came into focus. Using NPY family pepticles and NPY-related receptor-specific peptides as well as Y1 and Y2 receptor antagonists, we have tested which NPY Y receptors are involved in NPY-induced modulation of rat peritoneal macrophage function in vitro. NPY and PYY increased oxidative burst in phorbol myristate acetate (PMA)-stimulated macrophages involving activation of protein kinase C (PKC), and decreased it in zymosan-stimulated cells resembling inhibition of signaling pathways subsequent to binding of zymosan particles for the iC3b fragment receptor on macrophages. The combined treatment with NPY and NPY Y receptor antagonists revealed that NPY-induced potentiation of oxidative burst in PMA-stimulated cells is mediated through Y1 and Y2 receptors, while NPY-induced suppression in zymosan-stimu...lated cells is mediated through Y2 receptors only. NPY-related peptides differently modulated macrophage function, confirming involvement of NPY Y2 receptor in both potentiation and suppression of oxidative burst in these cells. Additionally, it was shown that NPY Y5 receptor mediated suppression of oxidative burst in PMA- and zymosan-stimulated macrophages. Taken together, the present data reveal an NPY Y1 and Y2/Y5 receptor interaction in NPY-induced modulation of macrophage functions related to inflammation. (C) 2004 Elsevier B.V. All rights reserved.

Keywords:
neuropeptide Y (NPY) / NPY receptors / macrophage / oxidative burst / dark agouti (DA) rats
Source:
Regulatory Peptides, 2005, 124, 1-3, 163-172
Publisher:
  • Elsevier, Amsterdam

DOI: 10.1016/j.regpep.2004.07.012

ISSN: 0167-0115

PubMed: 15544855

WoS: 000225638300021

Scopus: 2-s2.0-8444225461
[ Google Scholar ]
48
43
URI
http://intor.torlakinstitut.com/handle/123456789/200
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Torlak
TY  - JOUR
AU  - Dimitrijević, Mirjana
AU  - Stanojević, Stanislava
AU  - Vujić, Vesna
AU  - Beck-Sickinger, A.
AU  - von Hoersten, Stephan
PY  - 2005
UR  - http://intor.torlakinstitut.com/handle/123456789/200
AB  - It is well documented that neuropeptide Y (NPY) exerts a wide range of biological functions through at least five NPY Y receptor subtypes (Y1-Y5), but its immunological effects only recently came into focus. Using NPY family pepticles and NPY-related receptor-specific peptides as well as Y1 and Y2 receptor antagonists, we have tested which NPY Y receptors are involved in NPY-induced modulation of rat peritoneal macrophage function in vitro. NPY and PYY increased oxidative burst in phorbol myristate acetate (PMA)-stimulated macrophages involving activation of protein kinase C (PKC), and decreased it in zymosan-stimulated cells resembling inhibition of signaling pathways subsequent to binding of zymosan particles for the iC3b fragment receptor on macrophages. The combined treatment with NPY and NPY Y receptor antagonists revealed that NPY-induced potentiation of oxidative burst in PMA-stimulated cells is mediated through Y1 and Y2 receptors, while NPY-induced suppression in zymosan-stimulated cells is mediated through Y2 receptors only. NPY-related peptides differently modulated macrophage function, confirming involvement of NPY Y2 receptor in both potentiation and suppression of oxidative burst in these cells. Additionally, it was shown that NPY Y5 receptor mediated suppression of oxidative burst in PMA- and zymosan-stimulated macrophages. Taken together, the present data reveal an NPY Y1 and Y2/Y5 receptor interaction in NPY-induced modulation of macrophage functions related to inflammation. (C) 2004 Elsevier B.V. All rights reserved.
PB  - Elsevier, Amsterdam
T2  - Regulatory Peptides
T1  - Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptors
EP  - 172
IS  - 1-3
SP  - 163
VL  - 124
DO  - 10.1016/j.regpep.2004.07.012
UR  - conv_163
ER  - 
@article{
author = "Dimitrijević, Mirjana and Stanojević, Stanislava and Vujić, Vesna and Beck-Sickinger, A. and von Hoersten, Stephan",
year = "2005",
abstract = "It is well documented that neuropeptide Y (NPY) exerts a wide range of biological functions through at least five NPY Y receptor subtypes (Y1-Y5), but its immunological effects only recently came into focus. Using NPY family pepticles and NPY-related receptor-specific peptides as well as Y1 and Y2 receptor antagonists, we have tested which NPY Y receptors are involved in NPY-induced modulation of rat peritoneal macrophage function in vitro. NPY and PYY increased oxidative burst in phorbol myristate acetate (PMA)-stimulated macrophages involving activation of protein kinase C (PKC), and decreased it in zymosan-stimulated cells resembling inhibition of signaling pathways subsequent to binding of zymosan particles for the iC3b fragment receptor on macrophages. The combined treatment with NPY and NPY Y receptor antagonists revealed that NPY-induced potentiation of oxidative burst in PMA-stimulated cells is mediated through Y1 and Y2 receptors, while NPY-induced suppression in zymosan-stimulated cells is mediated through Y2 receptors only. NPY-related peptides differently modulated macrophage function, confirming involvement of NPY Y2 receptor in both potentiation and suppression of oxidative burst in these cells. Additionally, it was shown that NPY Y5 receptor mediated suppression of oxidative burst in PMA- and zymosan-stimulated macrophages. Taken together, the present data reveal an NPY Y1 and Y2/Y5 receptor interaction in NPY-induced modulation of macrophage functions related to inflammation. (C) 2004 Elsevier B.V. All rights reserved.",
publisher = "Elsevier, Amsterdam",
journal = "Regulatory Peptides",
title = "Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptors",
pages = "172-163",
number = "1-3",
volume = "124",
doi = "10.1016/j.regpep.2004.07.012",
url = "conv_163"
}
Dimitrijević, M., Stanojević, S., Vujić, V., Beck-Sickinger, A.,& von Hoersten, S.. (2005). Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptors. in Regulatory Peptides
Elsevier, Amsterdam., 124(1-3), 163-172.
https://doi.org/10.1016/j.regpep.2004.07.012
conv_163
Dimitrijević M, Stanojević S, Vujić V, Beck-Sickinger A, von Hoersten S. Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptors. in Regulatory Peptides. 2005;124(1-3):163-172.
doi:10.1016/j.regpep.2004.07.012
conv_163 .
Dimitrijević, Mirjana, Stanojević, Stanislava, Vujić, Vesna, Beck-Sickinger, A., von Hoersten, Stephan, "Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptors" in Regulatory Peptides, 124, no. 1-3 (2005):163-172,
https://doi.org/10.1016/j.regpep.2004.07.012 .,
conv_163 .

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