Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPYY1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26)
Само за регистроване кориснике
2002
Аутори
Dimitrijević, MirjanaStanojević, Stanislava
Vujić, Vesna
Kovačević-Jovanović, Vesna
Beck-Sickinger, A.
Demuth, H.U.
von Hoersten, Stephan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Several lines of evidence suggest that neuropeptide Y (NPY) may exert regulatory effects in local inflammatory responses. Here, we show that intraplantarly (i.pl.) applied NPY, peptide YY (PYY), and an NPY Y5 receptor-selective agonist dose-dependently potentiate concanavalin A (Con A)-induced paw edema in the rat. The NPY Y1 receptor antagonist BIBO 3304 abolishes the pro-inflammatory action of both NPY and PYY while the dipeptidyl-peptidase IV (CD26) inhibitor Ile-thiazolidide exerted synergistic and potentiating effects in vivo. Taken together, the present data reveal an NPY Y1/Y5 receptor interplay and an involvement of CD26 in the NPY-induced potentiation of paw edema in the rat. (C) 2002 Elsevier Science B.V. All rights reserved.
Кључне речи:
neuropeptide Y (NPY) / NPY receptors / dipeptidyl-peptidase IV (DPIV, CD26) / paw edema / inflammation / ratsИзвор:
Journal of Neuroimmunology, 2002, 129, 1-2, 35-42Издавач:
- Elsevier, Amsterdam
DOI: 10.1016/S0165-5728(02)00173-X
ISSN: 0165-5728
PubMed: 12161018
WoS: 000177797700005
Scopus: 2-s2.0-0036341096
Институција/група
TorlakTY - JOUR AU - Dimitrijević, Mirjana AU - Stanojević, Stanislava AU - Vujić, Vesna AU - Kovačević-Jovanović, Vesna AU - Beck-Sickinger, A. AU - Demuth, H.U. AU - von Hoersten, Stephan PY - 2002 UR - http://intor.torlakinstitut.com/handle/123456789/153 AB - Several lines of evidence suggest that neuropeptide Y (NPY) may exert regulatory effects in local inflammatory responses. Here, we show that intraplantarly (i.pl.) applied NPY, peptide YY (PYY), and an NPY Y5 receptor-selective agonist dose-dependently potentiate concanavalin A (Con A)-induced paw edema in the rat. The NPY Y1 receptor antagonist BIBO 3304 abolishes the pro-inflammatory action of both NPY and PYY while the dipeptidyl-peptidase IV (CD26) inhibitor Ile-thiazolidide exerted synergistic and potentiating effects in vivo. Taken together, the present data reveal an NPY Y1/Y5 receptor interplay and an involvement of CD26 in the NPY-induced potentiation of paw edema in the rat. (C) 2002 Elsevier Science B.V. All rights reserved. PB - Elsevier, Amsterdam T2 - Journal of Neuroimmunology T1 - Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPYY1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26) EP - 42 IS - 1-2 SP - 35 VL - 129 DO - 10.1016/S0165-5728(02)00173-X ER -
@article{ author = "Dimitrijević, Mirjana and Stanojević, Stanislava and Vujić, Vesna and Kovačević-Jovanović, Vesna and Beck-Sickinger, A. and Demuth, H.U. and von Hoersten, Stephan", year = "2002", abstract = "Several lines of evidence suggest that neuropeptide Y (NPY) may exert regulatory effects in local inflammatory responses. Here, we show that intraplantarly (i.pl.) applied NPY, peptide YY (PYY), and an NPY Y5 receptor-selective agonist dose-dependently potentiate concanavalin A (Con A)-induced paw edema in the rat. The NPY Y1 receptor antagonist BIBO 3304 abolishes the pro-inflammatory action of both NPY and PYY while the dipeptidyl-peptidase IV (CD26) inhibitor Ile-thiazolidide exerted synergistic and potentiating effects in vivo. Taken together, the present data reveal an NPY Y1/Y5 receptor interplay and an involvement of CD26 in the NPY-induced potentiation of paw edema in the rat. (C) 2002 Elsevier Science B.V. All rights reserved.", publisher = "Elsevier, Amsterdam", journal = "Journal of Neuroimmunology", title = "Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPYY1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26)", pages = "42-35", number = "1-2", volume = "129", doi = "10.1016/S0165-5728(02)00173-X" }
Dimitrijević, M., Stanojević, S., Vujić, V., Kovačević-Jovanović, V., Beck-Sickinger, A., Demuth, H.U.,& von Hoersten, S.. (2002). Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPYY1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26). in Journal of Neuroimmunology Elsevier, Amsterdam., 129(1-2), 35-42. https://doi.org/10.1016/S0165-5728(02)00173-X
Dimitrijević M, Stanojević S, Vujić V, Kovačević-Jovanović V, Beck-Sickinger A, Demuth H, von Hoersten S. Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPYY1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26). in Journal of Neuroimmunology. 2002;129(1-2):35-42. doi:10.1016/S0165-5728(02)00173-X .
Dimitrijević, Mirjana, Stanojević, Stanislava, Vujić, Vesna, Kovačević-Jovanović, Vesna, Beck-Sickinger, A., Demuth, H.U., von Hoersten, Stephan, "Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPYY1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26)" in Journal of Neuroimmunology, 129, no. 1-2 (2002):35-42, https://doi.org/10.1016/S0165-5728(02)00173-X . .