@article{
author = "Vujić, Vesna and Stanojević, Stanislava and Dimitrijević, Mirjana",
year = "2002",
abstract = "It is well documented that endogenous opioid peptides modulate the activity of immune and inflammatory cells. Opioid peptides exert biological effects through at least three opioid receptor types, known as µ, δ and κ. In the present study we have investigated which types of opioid receptors are involved in the opioid peptide-induced modulation of superoxide an/on release from macrophages. Rat peritoneal macrophages were stimulated with zymosan, and treated in vitro with opioid peptides and/or antagonists specific for different opioid receptor types. The results showed that the µ opioid receptor agonist, beta-endorphin, and the k opioid receptor agonist dynorphin A, decreased superoxide anion production. Conversely methionine-enkephalin (Met-Enk) and leucine-enkephalin, that have a preference for δ opioid receptors, did not affect superoxide anion release. Furthermore, we have tested the effect of Met-Enk on superoxide anion release from macrophages under blockade of all receptors with specific antagonists except for one receptor subtype. Accordingly, it was found that the Met-Enk induced increase and decrease of superoxide anion production were mediated through δ1,2 and µκ opioid receptors, respectively. It can be concluded that opposing activity of µ, and κ receptors vs. δ receptors together with the affinity for a ceflain receptor-type determines the effect of a particular endogenous opioid peptide on superoxide anion release from rat peritoneal macrophages., Poznato je da endogeni opioidni peptidi modulišu aktivnost imunskih i inflamatornih ćelija. Opioidni peptidi ostvaruju biološke efekte preko tri tipa receptora, µ, δ i κ. U ovom radu ispitivali smo koji tipovi opioidnih receptora učestvuju u opioidnoj modulaciji oslobadanjasuperoksid anjona iz peritonealnih makrofaga. Peritonealne makrofage pacova su stimulisane zimozanom, i tretirane in vitro sa opioidnim peptidima i/ili specifičnim antagonistima različitih tipova opioidnih receptora. Rezultati su pokazali da beta-endorphin, agonist µ, opiodnih receptora, i dynorphin A, agonist κ opiodnih receptora, smanjuju produkciju superoksid anjona. S druge strane metionin-enkefalin (Met-Enk) i leucin-enkefalin, koji se prevashodno vezuju za δ opioidne receptore, nisu uticali na oslobadanje superoksid anjona. Pored toga, ispitivali smo uticaj Met-Enk na oslobađanje superoksid anjona iz makrofaga u uslovima blokade svih receptora sa specifičnim antagonistima izuzev jednog tipa/podtipa opioidnog receptora. Shodno tome pokazali smo da Met-Enk povećava oslobadanje superoksid anjona preko δ1,2 a smanjuje oslobadanje superoksid anjona preko µk opioidnih receptora. Može se zaključiti da je uticaj endogenih opioidnih peptida na oslobadanje superoksid anjona iz peritonealnih makrofaga pacova određen suprotnom aktivnošću (µ i k receptora u odnosu na δ receptore, kao i različitim afinitetom peptida za pojedine tipove opioidnih receptora.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria - Beograd",
title = "The effect of opioid peptides on superoxide, anion production in rat peritoneal macrophages stimulated with zymosan: involvement of µ, δ and κ opioid receptors, Uticaj opioidnih peptida na produkciju superoksid anjona u peritonealnim makrofagama pacova stimulisanim zimozanom - uloga µ, δ i κ opioidnih receptora",
pages = "78-69",
number = "2-3",
volume = "52",
doi = "10.2298/AVB0203069V"
}