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Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPYY1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26)
dc.creator | Dimitrijević, Mirjana | |
dc.creator | Stanojević, Stanislava | |
dc.creator | Vujić, Vesna | |
dc.creator | Kovačević-Jovanović, Vesna | |
dc.creator | Beck-Sickinger, A. | |
dc.creator | Demuth, H.U. | |
dc.creator | von Hoersten, Stephan | |
dc.date.accessioned | 2021-02-18T10:25:02Z | |
dc.date.available | 2021-02-18T10:25:02Z | |
dc.date.issued | 2002 | |
dc.identifier.issn | 0165-5728 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/153 | |
dc.description.abstract | Several lines of evidence suggest that neuropeptide Y (NPY) may exert regulatory effects in local inflammatory responses. Here, we show that intraplantarly (i.pl.) applied NPY, peptide YY (PYY), and an NPY Y5 receptor-selective agonist dose-dependently potentiate concanavalin A (Con A)-induced paw edema in the rat. The NPY Y1 receptor antagonist BIBO 3304 abolishes the pro-inflammatory action of both NPY and PYY while the dipeptidyl-peptidase IV (CD26) inhibitor Ile-thiazolidide exerted synergistic and potentiating effects in vivo. Taken together, the present data reveal an NPY Y1/Y5 receptor interplay and an involvement of CD26 in the NPY-induced potentiation of paw edema in the rat. (C) 2002 Elsevier Science B.V. All rights reserved. | en |
dc.publisher | Elsevier, Amsterdam | |
dc.rights | restrictedAccess | |
dc.source | Journal of Neuroimmunology | |
dc.subject | neuropeptide Y (NPY) | en |
dc.subject | NPY receptors | en |
dc.subject | dipeptidyl-peptidase IV (DPIV, CD26) | en |
dc.subject | paw edema | en |
dc.subject | inflammation | en |
dc.subject | rats | en |
dc.title | Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPYY1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26) | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 42 | |
dc.citation.issue | 1-2 | |
dc.citation.other | 129(1-2): 35-42 | |
dc.citation.rank | M21 | |
dc.citation.spage | 35 | |
dc.citation.volume | 129 | |
dc.identifier.doi | 10.1016/S0165-5728(02)00173-X | |
dc.identifier.pmid | 12161018 | |
dc.identifier.scopus | 2-s2.0-0036341096 | |
dc.identifier.wos | 000177797700005 | |
dc.type.version | publishedVersion |