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Sex and age as determinants of rat T-cell phenotypic characteristics: influence of peripubertal gonadectomy
dc.creator | Arsenović-Ranin, Nevena | |
dc.creator | Kosec, Duško | |
dc.creator | Pilipović, Ivan | |
dc.creator | Nacka-Aleksić, Mirjana | |
dc.creator | Bufan, Biljana | |
dc.creator | Stojić-Vukanić, Zorica | |
dc.creator | Leposavić, Gordana | |
dc.date.accessioned | 2021-02-18T10:48:12Z | |
dc.date.available | 2021-02-18T10:48:12Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0300-8177 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/484 | |
dc.description.abstract | The study examined the influence of age, sex and peripubertal gonadectomy on a set of T-cell phenotypic parameters. Rats of both sexes were gonadectomised at the age of 1 month and peripheral blood and spleen T lymphocytes from non-gonadectomised and gonadectomised 3- and 11-month-old rats were examined for the expression of differentiation/activation (CD90/CD45RC) and immunoregulatory markers. Peripheral blood T lymphocytes from non-gonadectomised rats showed age-dependent sexual dimorphisms in (1) total count (lower in female than male 11-month-old rats); (2) CD4+:CD8 + cell ratio (higher in female than male rats of both ages); (3) the proportion of recent thymic emigrants in CD8 + T cells (lower in female than male 3-month-old rats) and (4) the proportions of mature na lt ve and memory/activated cells (irrespective of age, the proportion of na lt ve cells was higher, whereas that of memory/activated cells was lower in females). Gonadectomy influenced magnitudes or direction of these sex differences. Additionally, sex differences in peripheral blood T-lymphocyte parameters did not fully correspond to those observed in T-splenocyte parameters, suggesting the compartment-specific regulation of the major T-cell subpopulations' and their subsets' composition. Furthermore, there was no sexual dimorphism in the proportion of either CD25 + Foxp3 + cells among CD4 + or CD161+ (NKT) cells within CD8 + T lymphocytes. However, there was gonadal hormone-independent age-associated sexual dimorphism in the proportion of CD161 + cells (NKT cells) in CD8 + T splenocytes. Overall, the study revealed age-dependent variations in sexual dimorphisms in T-cell parameters relevant for immune response efficacy and showed that they are T-cell compartment-specific and partly gonadal hormone-related. | en |
dc.publisher | Springer, Dordrecht | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS// | |
dc.rights | restrictedAccess | |
dc.source | Molecular and Cellular Biochemistry | |
dc.subject | CD4:CD8+T-cell ratio | en |
dc.subject | Recent thymic emigrants | en |
dc.subject | Regulatory T cells | en |
dc.subject | Sex differences | en |
dc.subject | Gonadectomy | en |
dc.title | Sex and age as determinants of rat T-cell phenotypic characteristics: influence of peripubertal gonadectomy | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 185 | |
dc.citation.issue | 1-2 | |
dc.citation.other | 431(1-2): 169-185 | |
dc.citation.rank | M23 | |
dc.citation.spage | 169 | |
dc.citation.volume | 431 | |
dc.identifier.doi | 10.1007/s11010-017-2989-x | |
dc.identifier.pmid | 28281185 | |
dc.identifier.scopus | 2-s2.0-85014637872 | |
dc.identifier.wos | 000403416000019 | |
dc.type.version | publishedVersion |