TY  - JOUR
AU  - Štrbac, Mirjana
AU  - Vuković, Vladimir
AU  - Patić, Aleksandra
AU  - Medić, Snežana
AU  - Pustahija, Tatjana
AU  - Petrović, Vladimir
AU  - Lendak, Dajana
AU  - Kosanović Ličina, Mirjana
AU  - Bakić, Marijan
AU  - Protić, Jelena
AU  - Pranjić, Nurka
AU  - Jandrić, Ljubica
AU  - Sokolovska, Nikolina
AU  - Ristić, Mioljub
PY  - 2022
UR  - http://intor.torlakinstitut.com/handle/123456789/668
AB  - Background: Large-scale epidemics of haemorrhagic fever with renal syndrome (HFRS) have been reported mostly in Asia and Europe, with around 100,000 people affected each year. In the Southeast Europe, Balkan region, HFRS is endemic disease with approximately 100 cases per year. Our aim was to describe epidemiological characteristics of HFRS in five Western Balkan (WB) countries and to describe correlation between HFRS incidence and major meteorological event that hit the area in May 2014. Methods: National surveillance data of HFRS from Bosnia and Herzegovina, Croatia, Montenegro, North Macedonia and Serbia obtained from 1 January 2006 to 31 December 2015 were collected and analysed. Results: In a 10-year period, a total of 1,065 HFRS patients were reported in five WB countries. Cumulative incidence rate ranged from 0.05 to 15.80 per 100.000 inhabitants (in North Macedonia and Montenegro respectively). Increasing number of HFRS cases was reported with a peak incidence in three specific years (2008, 2012, and 2014). Average incidence for the entire area was higher in males than females (5.63 and 1.90 per 100.000 inhabitants respectively). Summer was the season with the highest number of cases and an average incidence rate of 1.74/100.000 inhabitants across 10-year period. Haemorrhagic fever with renal syndrome incidence was significantly increased (7.91/100.000 inhabitants) in 2014, when a few months earlier, severe floods affected several WB countries. A strong significant negative correlation (r = −.84, p < .01) between the monthly incidence of HFRS and the number of months after May's floods was demonstrated for the total area of WB. Conclusion: Our findings demonstrate that the HFRS incidence had similar distribution (general, age, sex and seasonality) across majority of the included countries. Summer was the season with the highest recorded incidence. Common epidemic years were detected in all observed countries as well as a negative correlation between the monthly incidence of HFRS and the number of months after May's cyclone.
PB  - Wiley
T2  - Zoonoses and Public Health
T1  - Epidemiological study on the incidence of haemorrhagic fever with renal syndrome in five Western Balkan countries for a 10-year period: 2006–2015
EP  - 206
IS  - 3
SP  - 195
VL  - 69
DO  - 10.1111/zph.12908
ER  - 

@article{
author = "Štrbac, Mirjana and Vuković, Vladimir and Patić, Aleksandra and Medić, Snežana and Pustahija, Tatjana and Petrović, Vladimir and Lendak, Dajana and Kosanović Ličina, Mirjana and Bakić, Marijan and Protić, Jelena and Pranjić, Nurka and Jandrić, Ljubica and Sokolovska, Nikolina and Ristić, Mioljub",
year = "2022",
abstract = "Background: Large-scale epidemics of haemorrhagic fever with renal syndrome (HFRS) have been reported mostly in Asia and Europe, with around 100,000 people affected each year. In the Southeast Europe, Balkan region, HFRS is endemic disease with approximately 100 cases per year. Our aim was to describe epidemiological characteristics of HFRS in five Western Balkan (WB) countries and to describe correlation between HFRS incidence and major meteorological event that hit the area in May 2014. Methods: National surveillance data of HFRS from Bosnia and Herzegovina, Croatia, Montenegro, North Macedonia and Serbia obtained from 1 January 2006 to 31 December 2015 were collected and analysed. Results: In a 10-year period, a total of 1,065 HFRS patients were reported in five WB countries. Cumulative incidence rate ranged from 0.05 to 15.80 per 100.000 inhabitants (in North Macedonia and Montenegro respectively). Increasing number of HFRS cases was reported with a peak incidence in three specific years (2008, 2012, and 2014). Average incidence for the entire area was higher in males than females (5.63 and 1.90 per 100.000 inhabitants respectively). Summer was the season with the highest number of cases and an average incidence rate of 1.74/100.000 inhabitants across 10-year period. Haemorrhagic fever with renal syndrome incidence was significantly increased (7.91/100.000 inhabitants) in 2014, when a few months earlier, severe floods affected several WB countries. A strong significant negative correlation (r = −.84, p < .01) between the monthly incidence of HFRS and the number of months after May's floods was demonstrated for the total area of WB. Conclusion: Our findings demonstrate that the HFRS incidence had similar distribution (general, age, sex and seasonality) across majority of the included countries. Summer was the season with the highest recorded incidence. Common epidemic years were detected in all observed countries as well as a negative correlation between the monthly incidence of HFRS and the number of months after May's cyclone.",
publisher = "Wiley",
journal = "Zoonoses and Public Health",
title = "Epidemiological study on the incidence of haemorrhagic fever with renal syndrome in five Western Balkan countries for a 10-year period: 2006–2015",
pages = "206-195",
number = "3",
volume = "69",
doi = "10.1111/zph.12908"
}

Štrbac, M., Vuković, V., Patić, A., Medić, S., Pustahija, T., Petrović, V., Lendak, D., Kosanović Ličina, M., Bakić, M., Protić, J., Pranjić, N., Jandrić, L., Sokolovska, N.,& Ristić, M.. (2022). Epidemiological study on the incidence of haemorrhagic fever with renal syndrome in five Western Balkan countries for a 10-year period: 2006–2015. in Zoonoses and Public Health
Wiley., 69(3), 195-206.
https://doi.org/10.1111/zph.12908

Štrbac M, Vuković V, Patić A, Medić S, Pustahija T, Petrović V, Lendak D, Kosanović Ličina M, Bakić M, Protić J, Pranjić N, Jandrić L, Sokolovska N, Ristić M. Epidemiological study on the incidence of haemorrhagic fever with renal syndrome in five Western Balkan countries for a 10-year period: 2006–2015. in Zoonoses and Public Health. 2022;69(3):195-206.
doi:10.1111/zph.12908 .

Štrbac, Mirjana, Vuković, Vladimir, Patić, Aleksandra, Medić, Snežana, Pustahija, Tatjana, Petrović, Vladimir, Lendak, Dajana, Kosanović Ličina, Mirjana, Bakić, Marijan, Protić, Jelena, Pranjić, Nurka, Jandrić, Ljubica, Sokolovska, Nikolina, Ristić, Mioljub, "Epidemiological study on the incidence of haemorrhagic fever with renal syndrome in five Western Balkan countries for a 10-year period: 2006–2015" in Zoonoses and Public Health, 69, no. 3 (2022):195-206,
https://doi.org/10.1111/zph.12908 . .

TY  - JOUR
AU  - Ristić, Mioljub
AU  - Šeguljev, Zorica
AU  - Petrović, Vladimir
AU  - Ćosić, Gorana
AU  - Milošević, Vesna
AU  - Matijašević, Jovan
AU  - Nedeljković, Jasminka
PY  - 2014
UR  - http://intor.torlakinstitut.com/handle/123456789/422
AB  - Introduction. Although influenza is longest and most studied infectious disease, to date, not much has been achieved in preventing and combating this disease. Many infectious diseases are now eliminated or significantly reduced, but only influenza remained epidemic and pandemic character. Influenza epidemics occur every year. Increase in number of patients occurs in early winter. Pandemics occur over long intervals of time and are caused by new subtypes of the influenza virus. Objective. To analyze the epidemiological characteristics of influenza through surveillance of influenza during 3 seasons of monitoring. Method. Data for the analysis were gathered from epidemiological surveillance of influenza through sentinel surveillance, virological surveillance and control of severe acute respiratory distress syndrome. Sentinel physician network consisted of doctors from the public sector, general practitioners, pediatricians, and specialists of emergency medicine and pulmonologists from intensive care units. Supervisors were experts from the Institute of Public Health of Vojvodina, Novi Sad. Samples from the patients (nasopharyngeal swabs) were tested by PCR in National Reference Laboratories (Institute of Virology, Vaccines and Sera 'Torlak' in Belgrade) and in Institute of Public Health of Vojvodina). Results. During the pandemic season, based on the recorded incidence or intensity of clinical activity, incidence rate of the influenza virus infections was above the intermediate threshold (246.3) for the territory of Vojvodina in the period from 45th to 52nd week of surveillance with the peak incidence at 50th week (1090.3 / 100,000). In the next two seasons of sentinel surveillance intensity of virus activity threshold was above the average over the period of 4 to 10 weeks (season 2010/11) and of 11 to 13 weeks of surveillance (season 2011/12). The largest number of patients was registered in the age group of 5-14 years, and the lowest number of patients was in age group over 65. Summarized results of virological surveillance of influenza show that during the pandemic season the most frequent isolate was the virus influenza A (H1N1). The largest number (24) of confirmed cases was registered in 51st week of surveillance, which coincided with the highest activity of the virus influenza during sentinel surveillance of ILI. Within virological surveillance in the season 2010/11 out of total of 213 tested samples of patient material, infection was confirmed in 112 samples: influenza A (H1N1) was confirmed in 90% (101/112), type B in 6.3% (7/112) and influenza A (H3N2) in 3.6% (4/112) samples. During the last season dominant infection was influenza A (H3N2) with a share of 96.5% (55/57) of all confirmed cases of sentinel and non-sentinel specimens tested. The average age of the 38 patients with fatal outcome during the seasons 2009/10 and 2010/11 was 47.1 (range: 12 to 76 years), and all were confirmed to infection with influenza virus A (H1N1). Obesity had the largest share as a factor of comorbidity, and was registered in 36.8% (14/38) patients with fatal outcome. Conclusion. The influenza virus is constantly present in a population with different intensity from year to year. Disease is the most often registered in the preschool and school children, but fatalities due to influenza are usually registered among the working population.
AB  - Uvod. Iako je influenca najduže i najviše izučavana zarazna bolest, do danas se nije mnogo postiglo u sprečavanju i suzbijanju ovog oboljenja. Mnoge zarazne bolesti su danas eliminisane ili je njihovo javljanje značajno smanjeno, ali je influenca zadržala epidemijski i pandemijski karakter. Epidemije influence se javljaju svake godine. U zemljama severne hemisfere epidemije imaju sezonski karakter. Porast broja obolelih je superponiran, odnosno poklapa se sa početkom zimskog perioda. Pandemije se javljaju u dužim vremenskim intervalima i uzrokovane su novim podtipovima virusa. Cilj rada. Analizirati epidemiološke karakteristike influence kroz nadzor nad gripom tokom tri sezone praćenja. Metod. Podaci za analizu potiču iz epidemiološkog nadzora nad gripom kroz predostrožni (sentinel) nadzor, virusološki nadzor i nadzor nad teškim akutnim respiratornim distres sindromom. Mrežu sentinel lekara činili su lekari iz državnog sektora, lekari opšte medicine i pedijatri, a u jedinicima intenzivne terapije specijalisti urgentne medicine i pulmolozi. Koordinatori nadzora su bili stručnjaci Instituta za javno zdravlje Vojvodine, Novi Sad. Rezultati. U AP Vojvodini, tokom pandemijske godine nadzora nad gripom, stopa incidencije je iznad srednjeg praga intenziteta u periodu od 45. nedelje tekuće godine do 1. nedelje naredne godine, dok su u postpandemijskom periodu vrednosti stopa incidencije iznad praga srednjeg intenziteta u periodu od 1. do 11. nedelje (sezona 2010/2011), odnosno od 11. do 14. nedelje (sezona 2011/2012) nadzora. Tokom pandemijske i naredne godine u uzorcima bolesničkog materijala (bris grla/nosa) dominira infekcija virusom gripa tip A podtip H1N1, a u sezoni 2011/2012 infekcija virusom gripa tip A podtip H3N2. Tokom pandemijske godine ukupan broj umrlih je 32, a tokom naredne sezone 6, dok u poslednjoj sezoni nadzora nisu registrovani smrtni ishodi od gripa. Najveće procentualno učešće umrlih je u uzrastu od 40 do 59 godina i iznosi 55,3% (21/38). Zaključak. Virus influence je konstantno prisutan u populaciji, s različitim intenzitetom aktivnosti od godine do godine. Oboljenje se najčešće registruje u predškolskom i školskom uzrastu, ali su smrtni ishodi zbog gripa najčešće registrovani među radno aktivnim stanovništvom.
PB  - Srpsko lekarsko društvo - Sekcija opšte medicine, Beograd
T2  - Opšta medicina
T1  - Results of influenza surveillance during the pandemic and post-pandemic influenza season in AP Vojvodina, Serbia
T1  - Rezultati nadzora nad gripom tokom pandemijske i postpandemijskih sezona u AP Vojvodini, Srbija
EP  - 41
IS  - 1-2
SP  - 35
VL  - 20
DO  - 10.5937/opmed1402035R
ER  - 

@article{
author = "Ristić, Mioljub and Šeguljev, Zorica and Petrović, Vladimir and Ćosić, Gorana and Milošević, Vesna and Matijašević, Jovan and Nedeljković, Jasminka",
year = "2014",
abstract = "Introduction. Although influenza is longest and most studied infectious disease, to date, not much has been achieved in preventing and combating this disease. Many infectious diseases are now eliminated or significantly reduced, but only influenza remained epidemic and pandemic character. Influenza epidemics occur every year. Increase in number of patients occurs in early winter. Pandemics occur over long intervals of time and are caused by new subtypes of the influenza virus. Objective. To analyze the epidemiological characteristics of influenza through surveillance of influenza during 3 seasons of monitoring. Method. Data for the analysis were gathered from epidemiological surveillance of influenza through sentinel surveillance, virological surveillance and control of severe acute respiratory distress syndrome. Sentinel physician network consisted of doctors from the public sector, general practitioners, pediatricians, and specialists of emergency medicine and pulmonologists from intensive care units. Supervisors were experts from the Institute of Public Health of Vojvodina, Novi Sad. Samples from the patients (nasopharyngeal swabs) were tested by PCR in National Reference Laboratories (Institute of Virology, Vaccines and Sera 'Torlak' in Belgrade) and in Institute of Public Health of Vojvodina). Results. During the pandemic season, based on the recorded incidence or intensity of clinical activity, incidence rate of the influenza virus infections was above the intermediate threshold (246.3) for the territory of Vojvodina in the period from 45th to 52nd week of surveillance with the peak incidence at 50th week (1090.3 / 100,000). In the next two seasons of sentinel surveillance intensity of virus activity threshold was above the average over the period of 4 to 10 weeks (season 2010/11) and of 11 to 13 weeks of surveillance (season 2011/12). The largest number of patients was registered in the age group of 5-14 years, and the lowest number of patients was in age group over 65. Summarized results of virological surveillance of influenza show that during the pandemic season the most frequent isolate was the virus influenza A (H1N1). The largest number (24) of confirmed cases was registered in 51st week of surveillance, which coincided with the highest activity of the virus influenza during sentinel surveillance of ILI. Within virological surveillance in the season 2010/11 out of total of 213 tested samples of patient material, infection was confirmed in 112 samples: influenza A (H1N1) was confirmed in 90% (101/112), type B in 6.3% (7/112) and influenza A (H3N2) in 3.6% (4/112) samples. During the last season dominant infection was influenza A (H3N2) with a share of 96.5% (55/57) of all confirmed cases of sentinel and non-sentinel specimens tested. The average age of the 38 patients with fatal outcome during the seasons 2009/10 and 2010/11 was 47.1 (range: 12 to 76 years), and all were confirmed to infection with influenza virus A (H1N1). Obesity had the largest share as a factor of comorbidity, and was registered in 36.8% (14/38) patients with fatal outcome. Conclusion. The influenza virus is constantly present in a population with different intensity from year to year. Disease is the most often registered in the preschool and school children, but fatalities due to influenza are usually registered among the working population., Uvod. Iako je influenca najduže i najviše izučavana zarazna bolest, do danas se nije mnogo postiglo u sprečavanju i suzbijanju ovog oboljenja. Mnoge zarazne bolesti su danas eliminisane ili je njihovo javljanje značajno smanjeno, ali je influenca zadržala epidemijski i pandemijski karakter. Epidemije influence se javljaju svake godine. U zemljama severne hemisfere epidemije imaju sezonski karakter. Porast broja obolelih je superponiran, odnosno poklapa se sa početkom zimskog perioda. Pandemije se javljaju u dužim vremenskim intervalima i uzrokovane su novim podtipovima virusa. Cilj rada. Analizirati epidemiološke karakteristike influence kroz nadzor nad gripom tokom tri sezone praćenja. Metod. Podaci za analizu potiču iz epidemiološkog nadzora nad gripom kroz predostrožni (sentinel) nadzor, virusološki nadzor i nadzor nad teškim akutnim respiratornim distres sindromom. Mrežu sentinel lekara činili su lekari iz državnog sektora, lekari opšte medicine i pedijatri, a u jedinicima intenzivne terapije specijalisti urgentne medicine i pulmolozi. Koordinatori nadzora su bili stručnjaci Instituta za javno zdravlje Vojvodine, Novi Sad. Rezultati. U AP Vojvodini, tokom pandemijske godine nadzora nad gripom, stopa incidencije je iznad srednjeg praga intenziteta u periodu od 45. nedelje tekuće godine do 1. nedelje naredne godine, dok su u postpandemijskom periodu vrednosti stopa incidencije iznad praga srednjeg intenziteta u periodu od 1. do 11. nedelje (sezona 2010/2011), odnosno od 11. do 14. nedelje (sezona 2011/2012) nadzora. Tokom pandemijske i naredne godine u uzorcima bolesničkog materijala (bris grla/nosa) dominira infekcija virusom gripa tip A podtip H1N1, a u sezoni 2011/2012 infekcija virusom gripa tip A podtip H3N2. Tokom pandemijske godine ukupan broj umrlih je 32, a tokom naredne sezone 6, dok u poslednjoj sezoni nadzora nisu registrovani smrtni ishodi od gripa. Najveće procentualno učešće umrlih je u uzrastu od 40 do 59 godina i iznosi 55,3% (21/38). Zaključak. Virus influence je konstantno prisutan u populaciji, s različitim intenzitetom aktivnosti od godine do godine. Oboljenje se najčešće registruje u predškolskom i školskom uzrastu, ali su smrtni ishodi zbog gripa najčešće registrovani među radno aktivnim stanovništvom.",
publisher = "Srpsko lekarsko društvo - Sekcija opšte medicine, Beograd",
journal = "Opšta medicina",
title = "Results of influenza surveillance during the pandemic and post-pandemic influenza season in AP Vojvodina, Serbia, Rezultati nadzora nad gripom tokom pandemijske i postpandemijskih sezona u AP Vojvodini, Srbija",
pages = "41-35",
number = "1-2",
volume = "20",
doi = "10.5937/opmed1402035R"
}

Ristić, M., Šeguljev, Z., Petrović, V., Ćosić, G., Milošević, V., Matijašević, J.,& Nedeljković, J.. (2014). Results of influenza surveillance during the pandemic and post-pandemic influenza season in AP Vojvodina, Serbia. in Opšta medicina
Srpsko lekarsko društvo - Sekcija opšte medicine, Beograd., 20(1-2), 35-41.
https://doi.org/10.5937/opmed1402035R

Ristić M, Šeguljev Z, Petrović V, Ćosić G, Milošević V, Matijašević J, Nedeljković J. Results of influenza surveillance during the pandemic and post-pandemic influenza season in AP Vojvodina, Serbia. in Opšta medicina. 2014;20(1-2):35-41.
doi:10.5937/opmed1402035R .

Ristić, Mioljub, Šeguljev, Zorica, Petrović, Vladimir, Ćosić, Gorana, Milošević, Vesna, Matijašević, Jovan, Nedeljković, Jasminka, "Results of influenza surveillance during the pandemic and post-pandemic influenza season in AP Vojvodina, Serbia" in Opšta medicina, 20, no. 1-2 (2014):35-41,
https://doi.org/10.5937/opmed1402035R . .

TY  - JOUR
AU  - Petrović, Vladimir
AU  - Šeguljev, Zorica
AU  - Nedeljković, Jasminka
AU  - Ristić, Mioljub
PY  - 2012
UR  - http://intor.torlakinstitut.com/handle/123456789/344
AB  - Introduction. The seroprevalence study was performed in Vojvodina during May and June 2010 in order to asses the effects of the 2009 pandemic influenza A(H1N1)v epidemic on herd immunity. It was a part of the Serbian Ministry of Health funded nationwide study. Objective. Prevalence of antibodies against 2009 pandemic influenza A(H1N1)v was determined in a 1% sample of the population monitored for influenza-like illness and acute respiratory infections in Vojvodina through sentinel surveillance system. Methods. The study sample involved a total of 1004 inhabitants of Vojvodina. The control group consisted of randomly selected and age-adjusted 1054 sera collected in the pre-pandemic period. Sera were tested by the reaction of hemagglutination inhibition using influenza A/California/7/2009 (H1N1) antigen in dilution from 1:8 to 1:256. Antibody titers ≥1:32 and ≥1:8 were considered protective and diagnostic, respectively. Results. The differences between control and study sera in all age groups were significant for both diagnostic ≥1/8 and protective titres ≥1/32 of hemagglutination inhibition antibodies (chi square test, p lt 0.001). The highest percentage of seropositive subjects was registered in the age group 15-19 years followed by children aged 5-14 years. Both diagnostic and protective titres were about twice higher in the vaccinated as compared to the non-vaccinated group. There were no statistically significant differences in seroprevalence between seven districts of Vojvodina. Conclusion. The 2009 pandemic influenza A(H1N1)v epidemic significantly influenced the herd immunity in our population regardless of low immunization coverage with highest immunity levels in adolescents aged 15-19 years and with similar herd immunity levels in all the regions in the province six months after the outbreak.
AB  - Uvod. Studija prevalencije antitela izvedena je u Vojvodini tokom maja i juna 2010. godine, kako bi se procenili efekti epidemije izazvane pandemijskim virusom gripa A­(H1N1)v iz 2009. godine na imunitet stanovništva. Studija je bila sastavni deo nacionalne studije koju je finansiralo Ministarstvo zdravlja Republike Srbije. Cilj rada. Prevalencija antitela protiv pandemijskog virusa gripa A­(H1N1)v je utvrđivana na jednoprocentnom uzorku populacije praćene sentinelnim nadzorom nad oboljenjima sličnim gripu i akutnim respiratornim infekcijama u Vojvodini radi procene imuniteta stanovništva Vojvodine. Metode rada. Ispitivanjem su obuhvaćena 1.004 stanovnika Vojvodine čiji serum je dat na analizu (studijska grupa). Kontrolnu grupu činio je uzorak seruma iz prepandemijskog perioda 1.054 nasumično odabrane osobe sličnog uzrasta. Serološko ispitivanje vršeno je reakcijom inhibicije hemaglutinacije antigenom virusa gripa A/Kalifornija/7/2009 (H1N1). Serumi su testirani u razblaženju od 1:8 do 1:256. Titar antitela u razblaženju većem od 1:32 smatrao se zaštitnim titrom, a u razblaženju većem od 1:8 dijagnostičkim. Rezultati. Utvrđena je visoko statistički značajna razlika (p lt 0,001) u prevalenciji antitela između studijske i kontrolne grupe, kako u dijagnostičkom (≥1:8), tako i u zaštitnom titru (≥1:32) hemaglutinin-inhibirajućih antitela. Najveći procenat seropozitivnih ispitanika otkriven je u dobnoj grupi 15–19 godina, a zatim u grupi 5–14 godina. Prevalencija antitela i u dijagnostičkom i u zaštitnom titru bila je dva puta veća kod vakcinisanih osoba u odnosu na nevakcinisane. Nije utvrđena statistički značajna razlika u seroprevalenciji između pojedinih okruga Vojvodine. Zaključak. Utvrđen je visok kolektivni imunitet, bez teritorijalnih razlika, prema pandemijskom virusu gripa A­(H1N1)v iz 2009. godine uprkos slabom obuhvatu stanovništva imunizacijom. Najveće vrednosti su zabeležene kod adolescenata uzrasta od 15 do 19 godina.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Seroprevalence study in Vojvodina (Serbia) following 2009 pandemic influenza A(H1N1)v
T1  - Studija prevalencije antitela u Vojvodini (Srbija) nakon pandemije gripa A-(H1N1)v 2009. godine
EP  - 755
IS  - 11-12
SP  - 751
VL  - 140
DO  - 10.2298/SARH1212751P
ER  - 

@article{
author = "Petrović, Vladimir and Šeguljev, Zorica and Nedeljković, Jasminka and Ristić, Mioljub",
year = "2012",
abstract = "Introduction. The seroprevalence study was performed in Vojvodina during May and June 2010 in order to asses the effects of the 2009 pandemic influenza A(H1N1)v epidemic on herd immunity. It was a part of the Serbian Ministry of Health funded nationwide study. Objective. Prevalence of antibodies against 2009 pandemic influenza A(H1N1)v was determined in a 1% sample of the population monitored for influenza-like illness and acute respiratory infections in Vojvodina through sentinel surveillance system. Methods. The study sample involved a total of 1004 inhabitants of Vojvodina. The control group consisted of randomly selected and age-adjusted 1054 sera collected in the pre-pandemic period. Sera were tested by the reaction of hemagglutination inhibition using influenza A/California/7/2009 (H1N1) antigen in dilution from 1:8 to 1:256. Antibody titers ≥1:32 and ≥1:8 were considered protective and diagnostic, respectively. Results. The differences between control and study sera in all age groups were significant for both diagnostic ≥1/8 and protective titres ≥1/32 of hemagglutination inhibition antibodies (chi square test, p lt 0.001). The highest percentage of seropositive subjects was registered in the age group 15-19 years followed by children aged 5-14 years. Both diagnostic and protective titres were about twice higher in the vaccinated as compared to the non-vaccinated group. There were no statistically significant differences in seroprevalence between seven districts of Vojvodina. Conclusion. The 2009 pandemic influenza A(H1N1)v epidemic significantly influenced the herd immunity in our population regardless of low immunization coverage with highest immunity levels in adolescents aged 15-19 years and with similar herd immunity levels in all the regions in the province six months after the outbreak., Uvod. Studija prevalencije antitela izvedena je u Vojvodini tokom maja i juna 2010. godine, kako bi se procenili efekti epidemije izazvane pandemijskim virusom gripa A­(H1N1)v iz 2009. godine na imunitet stanovništva. Studija je bila sastavni deo nacionalne studije koju je finansiralo Ministarstvo zdravlja Republike Srbije. Cilj rada. Prevalencija antitela protiv pandemijskog virusa gripa A­(H1N1)v je utvrđivana na jednoprocentnom uzorku populacije praćene sentinelnim nadzorom nad oboljenjima sličnim gripu i akutnim respiratornim infekcijama u Vojvodini radi procene imuniteta stanovništva Vojvodine. Metode rada. Ispitivanjem su obuhvaćena 1.004 stanovnika Vojvodine čiji serum je dat na analizu (studijska grupa). Kontrolnu grupu činio je uzorak seruma iz prepandemijskog perioda 1.054 nasumično odabrane osobe sličnog uzrasta. Serološko ispitivanje vršeno je reakcijom inhibicije hemaglutinacije antigenom virusa gripa A/Kalifornija/7/2009 (H1N1). Serumi su testirani u razblaženju od 1:8 do 1:256. Titar antitela u razblaženju većem od 1:32 smatrao se zaštitnim titrom, a u razblaženju većem od 1:8 dijagnostičkim. Rezultati. Utvrđena je visoko statistički značajna razlika (p lt 0,001) u prevalenciji antitela između studijske i kontrolne grupe, kako u dijagnostičkom (≥1:8), tako i u zaštitnom titru (≥1:32) hemaglutinin-inhibirajućih antitela. Najveći procenat seropozitivnih ispitanika otkriven je u dobnoj grupi 15–19 godina, a zatim u grupi 5–14 godina. Prevalencija antitela i u dijagnostičkom i u zaštitnom titru bila je dva puta veća kod vakcinisanih osoba u odnosu na nevakcinisane. Nije utvrđena statistički značajna razlika u seroprevalenciji između pojedinih okruga Vojvodine. Zaključak. Utvrđen je visok kolektivni imunitet, bez teritorijalnih razlika, prema pandemijskom virusu gripa A­(H1N1)v iz 2009. godine uprkos slabom obuhvatu stanovništva imunizacijom. Najveće vrednosti su zabeležene kod adolescenata uzrasta od 15 do 19 godina.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Seroprevalence study in Vojvodina (Serbia) following 2009 pandemic influenza A(H1N1)v, Studija prevalencije antitela u Vojvodini (Srbija) nakon pandemije gripa A-(H1N1)v 2009. godine",
pages = "755-751",
number = "11-12",
volume = "140",
doi = "10.2298/SARH1212751P"
}

Petrović, V., Šeguljev, Z., Nedeljković, J.,& Ristić, M.. (2012). Seroprevalence study in Vojvodina (Serbia) following 2009 pandemic influenza A(H1N1)v. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 140(11-12), 751-755.
https://doi.org/10.2298/SARH1212751P

Petrović V, Šeguljev Z, Nedeljković J, Ristić M. Seroprevalence study in Vojvodina (Serbia) following 2009 pandemic influenza A(H1N1)v. in Srpski arhiv za celokupno lekarstvo. 2012;140(11-12):751-755.
doi:10.2298/SARH1212751P .

Petrović, Vladimir, Šeguljev, Zorica, Nedeljković, Jasminka, Ristić, Mioljub, "Seroprevalence study in Vojvodina (Serbia) following 2009 pandemic influenza A(H1N1)v" in Srpski arhiv za celokupno lekarstvo, 140, no. 11-12 (2012):751-755,
https://doi.org/10.2298/SARH1212751P . .

TY  - JOUR
AU  - Rajcević, S.
AU  - Šeguljev, Zorica
AU  - Petrović, Vladimir
AU  - Medić, Snežana
AU  - Nedeljković, Jasminka
AU  - Milošević, V.
AU  - Turo, L.
AU  - Ristić, Mioljub
PY  - 2012
UR  - http://intor.torlakinstitut.com/handle/123456789/356
AB  - From 16 January to 30 April 2012, a total of 119 cases of mumps were notified in Novi Sad, Serbia. Of these cases, 89 (75%), were among students. The average age of cases was 22 years-old ( range 3-37). The outbreak is still ongoing in Novi Sad and is spreading to other parts of the Vojvodina province. As of 30 April, 209 cases have been notified in the province among those 119 from Novi Sad.
PB  - Eur Centre Dis Prevention & Control, Stockholm
T2  - Eurosurveillance
T1  - Ongoing mumps outbreak in Novi Sad, the autonomous province of Vojvodina, Serbia, January to April 2012
EP  - 4
IS  - 19
SP  - 2
VL  - 17
UR  - https://hdl.handle.net/21.15107/rcub_intor_356
ER  - 

@article{
author = "Rajcević, S. and Šeguljev, Zorica and Petrović, Vladimir and Medić, Snežana and Nedeljković, Jasminka and Milošević, V. and Turo, L. and Ristić, Mioljub",
year = "2012",
abstract = "From 16 January to 30 April 2012, a total of 119 cases of mumps were notified in Novi Sad, Serbia. Of these cases, 89 (75%), were among students. The average age of cases was 22 years-old ( range 3-37). The outbreak is still ongoing in Novi Sad and is spreading to other parts of the Vojvodina province. As of 30 April, 209 cases have been notified in the province among those 119 from Novi Sad.",
publisher = "Eur Centre Dis Prevention & Control, Stockholm",
journal = "Eurosurveillance",
title = "Ongoing mumps outbreak in Novi Sad, the autonomous province of Vojvodina, Serbia, January to April 2012",
pages = "4-2",
number = "19",
volume = "17",
url = "https://hdl.handle.net/21.15107/rcub_intor_356"
}

Rajcević, S., Šeguljev, Z., Petrović, V., Medić, S., Nedeljković, J., Milošević, V., Turo, L.,& Ristić, M.. (2012). Ongoing mumps outbreak in Novi Sad, the autonomous province of Vojvodina, Serbia, January to April 2012. in Eurosurveillance
Eur Centre Dis Prevention & Control, Stockholm., 17(19), 2-4.
https://hdl.handle.net/21.15107/rcub_intor_356

Rajcević S, Šeguljev Z, Petrović V, Medić S, Nedeljković J, Milošević V, Turo L, Ristić M. Ongoing mumps outbreak in Novi Sad, the autonomous province of Vojvodina, Serbia, January to April 2012. in Eurosurveillance. 2012;17(19):2-4.
https://hdl.handle.net/21.15107/rcub_intor_356 .

Rajcević, S., Šeguljev, Zorica, Petrović, Vladimir, Medić, Snežana, Nedeljković, Jasminka, Milošević, V., Turo, L., Ristić, Mioljub, "Ongoing mumps outbreak in Novi Sad, the autonomous province of Vojvodina, Serbia, January to April 2012" in Eurosurveillance, 17, no. 19 (2012):2-4,
https://hdl.handle.net/21.15107/rcub_intor_356 .

TY  - JOUR
AU  - Petrović, Vladimir
AU  - Šeguljev, Zorica
AU  - Ćosić, Gorana
AU  - Ristić, Mioljub
AU  - Nedeljković, Jasminka
AU  - Dragnić, Nataša
AU  - Ukropina, Snezana
PY  - 2011
UR  - http://intor.torlakinstitut.com/handle/123456789/323
AB  - Aim To analyze the epidemiological data for pandemic influenza A(H1N1)v in the Autonomous Province of Vojvodina, Serbia, during the season of 2009/2010 and to assess whether including severe acute respiratory illness (SARI) hospitalization data to the surveillance system gives a more complete picture of the impact of influenza during the pandemic. Methods From September 2009 to September 2010, the Institute of Public Health of Vojvodina conducted sentinel surveillance of influenza-like illnesses and acute respiratory infections in all hospitalized patients with SARI and virological surveillance of population of Vojvodina according to the European Centers for Disease Control technical document. Results The pandemic influenza outbreak in the province started in October 2009 (week 44) in students who had returned from a school-organized trip to Prague, Bratislava, and Vienna. The highest incidence rate was 1090 per 100 000 inhabitants, found in the week 50. The most affected age group were children 5-14 years old. A total of 1591 patients with severe illness were admitted to regional hospitals, with a case fatality rate of 2%, representing a hospitalization rate of 78.3 per 100 000 inhabitants and a mortality rate of 1.6 per 100 000. Most frequently hospitalized were 15-19 years old patients, male patients, and patients with pneumonia (P  lt  0.001). The highest case fatality rate was found among patients with acute respiratory distress syndrome (P  lt  0.001). Nasal/throat swabs were obtained for polymerase chain reaction test from 315 hospitalized patients and 20 non-hospitalized patients, and 145 (46%) and 15 (75%) specimens, respectively, tested positive on A(H1N1)v. Conclusion Sentinel influenza-like illness and SARI surveillance, both followed with virological surveillance, seem to be the optimal method to monitor the full scope of the influenza pandemic (from mild to severe influenza) in Vojvodina.
PB  - Medicinska Naklada, Zagreb
T2  - Croatian Medical Journal
T1  - Overview of the winter wave of 2009 pandemic influenza A(H1N1)v in Vojvodina, Serbia
EP  - 150
IS  - 2
SP  - 141
VL  - 52
DO  - 10.3325/cmj.2011.52.141
ER  - 

@article{
author = "Petrović, Vladimir and Šeguljev, Zorica and Ćosić, Gorana and Ristić, Mioljub and Nedeljković, Jasminka and Dragnić, Nataša and Ukropina, Snezana",
year = "2011",
abstract = "Aim To analyze the epidemiological data for pandemic influenza A(H1N1)v in the Autonomous Province of Vojvodina, Serbia, during the season of 2009/2010 and to assess whether including severe acute respiratory illness (SARI) hospitalization data to the surveillance system gives a more complete picture of the impact of influenza during the pandemic. Methods From September 2009 to September 2010, the Institute of Public Health of Vojvodina conducted sentinel surveillance of influenza-like illnesses and acute respiratory infections in all hospitalized patients with SARI and virological surveillance of population of Vojvodina according to the European Centers for Disease Control technical document. Results The pandemic influenza outbreak in the province started in October 2009 (week 44) in students who had returned from a school-organized trip to Prague, Bratislava, and Vienna. The highest incidence rate was 1090 per 100 000 inhabitants, found in the week 50. The most affected age group were children 5-14 years old. A total of 1591 patients with severe illness were admitted to regional hospitals, with a case fatality rate of 2%, representing a hospitalization rate of 78.3 per 100 000 inhabitants and a mortality rate of 1.6 per 100 000. Most frequently hospitalized were 15-19 years old patients, male patients, and patients with pneumonia (P  lt  0.001). The highest case fatality rate was found among patients with acute respiratory distress syndrome (P  lt  0.001). Nasal/throat swabs were obtained for polymerase chain reaction test from 315 hospitalized patients and 20 non-hospitalized patients, and 145 (46%) and 15 (75%) specimens, respectively, tested positive on A(H1N1)v. Conclusion Sentinel influenza-like illness and SARI surveillance, both followed with virological surveillance, seem to be the optimal method to monitor the full scope of the influenza pandemic (from mild to severe influenza) in Vojvodina.",
publisher = "Medicinska Naklada, Zagreb",
journal = "Croatian Medical Journal",
title = "Overview of the winter wave of 2009 pandemic influenza A(H1N1)v in Vojvodina, Serbia",
pages = "150-141",
number = "2",
volume = "52",
doi = "10.3325/cmj.2011.52.141"
}

Petrović, V., Šeguljev, Z., Ćosić, G., Ristić, M., Nedeljković, J., Dragnić, N.,& Ukropina, S.. (2011). Overview of the winter wave of 2009 pandemic influenza A(H1N1)v in Vojvodina, Serbia. in Croatian Medical Journal
Medicinska Naklada, Zagreb., 52(2), 141-150.
https://doi.org/10.3325/cmj.2011.52.141

Petrović V, Šeguljev Z, Ćosić G, Ristić M, Nedeljković J, Dragnić N, Ukropina S. Overview of the winter wave of 2009 pandemic influenza A(H1N1)v in Vojvodina, Serbia. in Croatian Medical Journal. 2011;52(2):141-150.
doi:10.3325/cmj.2011.52.141 .

Petrović, Vladimir, Šeguljev, Zorica, Ćosić, Gorana, Ristić, Mioljub, Nedeljković, Jasminka, Dragnić, Nataša, Ukropina, Snezana, "Overview of the winter wave of 2009 pandemic influenza A(H1N1)v in Vojvodina, Serbia" in Croatian Medical Journal, 52, no. 2 (2011):141-150,
https://doi.org/10.3325/cmj.2011.52.141 . .

TY  - JOUR
AU  - Ristić, Mioljub
AU  - Šeguljev, Zorica
AU  - Nedeljković, Jasminka
AU  - Ilić, Svetlana
AU  - Injac, Dragica
AU  - Đekić, Jelena
PY  - 2010
UR  - http://intor.torlakinstitut.com/handle/123456789/309
AB  - Introduction. Influenza is the most frequently reported communicable disease, having epidemic and pandemic potential. The first influenza pandemic in this century started in Mexico and spread quickly throughout the world. This paper analyses importation of pandemic influenza cases and local transmission among population in the Autonomous Province of Vojvodina. Material and methods. According to the WHO guidelines and national recommendations, the influenza surveillance activities were conducted in Vojvodina in order to detect, isolate and treat affected international travelers and their close contacts. Patients whose pandemic influenza infection was laboratory confirmed were classified as confirmed cases, while those with symptoms who were epidemiologically linked with confirmed cases were classified as probable cases. Results. During the period from the 24th of June to 17th of August 2009, 123 pandemic influenza cases were recorded in Vojvodina. Infection was imported through international travelers and our citizens coming from countries affected by influenza outbreaks. Majority of cases had mild clinical picture. Most frequently reported symptoms were high fever (above 38oC) (85.6%), and cough (61.6%). Difficulty in breathing was recorded in 20 (16.0%) cases, while pneumonia developed in 4 (3.2%) cases but none of the cases required mechanical ventilation. Conclusion. The imported cases of pandemic influenza in the pre-epidemic period led to limited local transmission in general population and caused a small outbreak among visitors of International music festival called EXIT.
AB  - Influenca je najčešća zarazna bolest sa pandemijskim potencijalom. Prva pandemija influence u ovom veku krenula je iz Meksika i brzo zahvatila čitav svet. Rad analizira importovanje prvih slučajeva i lokalno širenje pandemijske influence među stanovnicima Vojvodine. Nadzorom nad influencom u Pokrajini, u skladu sa smernicama Svetske zdravstvene organizacije i nacionalnim preporukama, obuhvaćeni su putnici u međunarodnom saobraćaju i njihovi kontakti. Bolesnici kod kojih je dokazana infekcija virusom influence A(H1N1) klasifikovani su kao potvrđeni slučajevi, dok su oni sa simptomima influence, epidemiološki povezani sa potvrđenim slučajevima, klasifikovani kao verovatni slučajevi. U periodu od 24. juna do 17. avgusta 2009. godine, na teritoriji Pokrajine su registrovana 123 slučaja pandemijske influence. Infekcija je importovana preko stranih i naših građana koji su dolazili iz zemalja sa lokalnom transmisijom virusa. Importovani slučajevi doveli su u predsezonskom periodu do ograničene lokalne transmisije u opštoj populaciji i epidemijskog širenja među učesnicima Egzita.
PB  - Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad
T2  - Medicinski pregled
T1  - Importation and spread of pandemic influenza virus a(H1N1) in Autonomous Province of vojvodina in preepidemic period
T1  - Importovanje i širenje pandemijskog virusa influence a(H1N1) u Autonomnoj Pokrajini Vojvodini u predsezonskom periodu
EP  - 505
IS  - 7-8
SP  - 502
VL  - 63
DO  - 10.2298/MPNS1008502R
ER  - 

@article{
author = "Ristić, Mioljub and Šeguljev, Zorica and Nedeljković, Jasminka and Ilić, Svetlana and Injac, Dragica and Đekić, Jelena",
year = "2010",
abstract = "Introduction. Influenza is the most frequently reported communicable disease, having epidemic and pandemic potential. The first influenza pandemic in this century started in Mexico and spread quickly throughout the world. This paper analyses importation of pandemic influenza cases and local transmission among population in the Autonomous Province of Vojvodina. Material and methods. According to the WHO guidelines and national recommendations, the influenza surveillance activities were conducted in Vojvodina in order to detect, isolate and treat affected international travelers and their close contacts. Patients whose pandemic influenza infection was laboratory confirmed were classified as confirmed cases, while those with symptoms who were epidemiologically linked with confirmed cases were classified as probable cases. Results. During the period from the 24th of June to 17th of August 2009, 123 pandemic influenza cases were recorded in Vojvodina. Infection was imported through international travelers and our citizens coming from countries affected by influenza outbreaks. Majority of cases had mild clinical picture. Most frequently reported symptoms were high fever (above 38oC) (85.6%), and cough (61.6%). Difficulty in breathing was recorded in 20 (16.0%) cases, while pneumonia developed in 4 (3.2%) cases but none of the cases required mechanical ventilation. Conclusion. The imported cases of pandemic influenza in the pre-epidemic period led to limited local transmission in general population and caused a small outbreak among visitors of International music festival called EXIT., Influenca je najčešća zarazna bolest sa pandemijskim potencijalom. Prva pandemija influence u ovom veku krenula je iz Meksika i brzo zahvatila čitav svet. Rad analizira importovanje prvih slučajeva i lokalno širenje pandemijske influence među stanovnicima Vojvodine. Nadzorom nad influencom u Pokrajini, u skladu sa smernicama Svetske zdravstvene organizacije i nacionalnim preporukama, obuhvaćeni su putnici u međunarodnom saobraćaju i njihovi kontakti. Bolesnici kod kojih je dokazana infekcija virusom influence A(H1N1) klasifikovani su kao potvrđeni slučajevi, dok su oni sa simptomima influence, epidemiološki povezani sa potvrđenim slučajevima, klasifikovani kao verovatni slučajevi. U periodu od 24. juna do 17. avgusta 2009. godine, na teritoriji Pokrajine su registrovana 123 slučaja pandemijske influence. Infekcija je importovana preko stranih i naših građana koji su dolazili iz zemalja sa lokalnom transmisijom virusa. Importovani slučajevi doveli su u predsezonskom periodu do ograničene lokalne transmisije u opštoj populaciji i epidemijskog širenja među učesnicima Egzita.",
publisher = "Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad",
journal = "Medicinski pregled",
title = "Importation and spread of pandemic influenza virus a(H1N1) in Autonomous Province of vojvodina in preepidemic period, Importovanje i širenje pandemijskog virusa influence a(H1N1) u Autonomnoj Pokrajini Vojvodini u predsezonskom periodu",
pages = "505-502",
number = "7-8",
volume = "63",
doi = "10.2298/MPNS1008502R"
}

Ristić, M., Šeguljev, Z., Nedeljković, J., Ilić, S., Injac, D.,& Đekić, J.. (2010). Importation and spread of pandemic influenza virus a(H1N1) in Autonomous Province of vojvodina in preepidemic period. in Medicinski pregled
Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad., 63(7-8), 502-505.
https://doi.org/10.2298/MPNS1008502R

Ristić M, Šeguljev Z, Nedeljković J, Ilić S, Injac D, Đekić J. Importation and spread of pandemic influenza virus a(H1N1) in Autonomous Province of vojvodina in preepidemic period. in Medicinski pregled. 2010;63(7-8):502-505.
doi:10.2298/MPNS1008502R .

Ristić, Mioljub, Šeguljev, Zorica, Nedeljković, Jasminka, Ilić, Svetlana, Injac, Dragica, Đekić, Jelena, "Importation and spread of pandemic influenza virus a(H1N1) in Autonomous Province of vojvodina in preepidemic period" in Medicinski pregled, 63, no. 7-8 (2010):502-505,
https://doi.org/10.2298/MPNS1008502R . .