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The influence of aging and estradiol to progesterone ratio on rat macrophage phenotypic profile and NO and TNF-alpha production
(Pergamon-Elsevier Science Ltd, Oxford, 2013)
The phenotype and function of tissue macrophages substantially depend on the cellular milieu and biological effector molecules, such as steroid hormones, to which they are exposed. Furthermore, in female rats, aging is ...
Peritoneal mast cell degranulation differently affected thioglycollate-induced macrophage phenotype and activity in Dark Agouti and Albino Oxford rats
(Pergamon-Elsevier Science Ltd, Oxford, 2013)
Aims: Macrophages are heterogeneous population of inflammatory cells and, in response to the microenvironment, become differentially activated. The objective of the study was to explore macrophage effector functions during ...
Adrenal hormone deprivation affects macrophage catecholamine metabolism and 2-adrenoceptor density, but not propranolol stimulation of tumour necrosis factor- production
(Wiley-Blackwell, Hoboken, 2013)
New Findings center dot What is the central question of this study? Glucocorticoids modulate extraglandular catecholamine metabolism and adrenoceptor expression in many cell types. Catecholamines modulate the production ...
The effects of corticosterone and beta-endorphin on adherence, phagocytosis and hydrogen peroxide production of macrophages isolated from Dark Agouti rats exposed to acute stress
(Karger, Basel, 2008)
Background: Given that stressful experiences can change the reaction to a subsequent exposure to stress, we tested the in vitro effects of the stress mediator corticosterone and the opioid peptide beta-endorphin on the ...
NPY suppressed development of experimental autoimmune encephalomyelitis in Dark Agouti rats by disrupting costimulatory molecule interactions
(Elsevier, Amsterdam, 2012)
Neuropeptide Y (NPY) suppressed clinical experimental autoimmune encephalomyelitis (EAE) and reduced numbers of CD28+, CD11b+ and CD80+ cells among spinal cord infiltrating cells at the peak of disease in Dark Agouti rat ...
Strain differences in the humoral immune response to commensal bacterial antigens in rats
(Akademiai Kiado Rt, Budapest, 2013)
We have investigated the immune response to commensal bacterial species in the two inbred rat strains: Dark Agouti (DA) and Albino Oxford (AO). The predominant Gram-negative aerobe in our rats' intestinal bacterial flora ...
Peripubertal ovariectomy influences thymic adrenergic network plasticity in adult rats
(Elsevier Science Bv, Amsterdam, 2016)
The study investigated the influence of peripubertal ovariectomy on the thymic noradrenaline (NA) concentration, and the thymocyte NA content and beta(2)- and alpha(1)-adrenoceptor (AR) expression in adult 2- and 11-month-old ...
Propranolol influences EAE development by impairing antigen presenting cell migration into the draining lymph nodes
(Abstracts of the 5th European Congress of Immunology - ECI 2018 - Amsterdam, The Netherlands, 2018)
Introduction: Catecholamines are implicated in development of multiple sclerosis and EAE in Dark Agouti (DA) rats. To enlighten their β−adrenoceptor−mediated immunomodulatory action, DA rats of both sexes immunized for EAE ...
Sexual dimorphism in mechanisms controlling development of CD4+ T cell response in collagen-induced arthritis
(5th European Congress of Immunology, Septembar 2-5, Abstract Book, 2018)
Introduction: Considering sex bias in rheumatoid arthritis prevalence, influence of biological sex on the disease development in Dark Agouti rat collagen II (CII)−induced arthritis (CIA) model of the human disease was ...
The Effect of Lactobacillus Helveticus L10 Supplementation on Respiratory Infections and Mucosal Immunity in Elite Athletes
(Lippincott Williams & Wilkins, Philadelphia, 2016)