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Effects of beta-adrenoceptor blockade on the phenotypic characteristics of thymocytes and peripheral blood lymphocytes
dc.creator | Rauški, Aleksandra | |
dc.creator | Kosec, Duško | |
dc.creator | Vidić-Danković, Biljana | |
dc.creator | Plećaš-Solarović, Bosiljka | |
dc.creator | Leposavić, Gordana | |
dc.date.accessioned | 2021-02-18T10:25:41Z | |
dc.date.available | 2021-02-18T10:25:41Z | |
dc.date.issued | 2003 | |
dc.identifier.issn | 0020-7454 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/162 | |
dc.description.abstract | The study revealed that beta-adrenoceptor blockade with propranolol (0.40 mg/100 g/day, s.c.) in adult male DA rats: (i) increased the thymocyte proliferation and apoptosis, (ii) caused disturbances in kinetics of T cell differentiation leading to distinguishable changes in relative proportion of thymocytes at distinct maturational steps and to an expansion of the most mature single positive (CD4+, CD8+) thymocyte pool, (iii) affected the relative proportion of neither CD4+ nor CD8+ peripheral blood lymphocytes (PBL), and (iv) augmented the relative number of CD8+CD25+ cells. Thus, the results suggest the role of beta-adrenoceptors in fine-tuning of T cell maturation, and, possibly, distribution and activation of distinct PBL subsets. | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.rights | restrictedAccess | |
dc.source | International Journal of Neuroscience | |
dc.subject | beta-adrenoceptor blockade | en |
dc.subject | peripheral T-cell phenotype | en |
dc.subject | thymocyte apoptosis | en |
dc.subject | thymocyte differentiation | en |
dc.subject | thymocyte proliferation | en |
dc.title | Effects of beta-adrenoceptor blockade on the phenotypic characteristics of thymocytes and peripheral blood lymphocytes | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 1673 | |
dc.citation.issue | 12 | |
dc.citation.other | 113(12): 1653-1673 | |
dc.citation.rank | M23 | |
dc.citation.spage | 1653 | |
dc.citation.volume | 113 | |
dc.identifier.doi | 10.1080/00207450390245216 | |
dc.identifier.pmid | 14602539 | |
dc.identifier.scopus | 2-s2.0-10744222299 | |
dc.identifier.wos | 000186897000002 | |
dc.type.version | publishedVersion |