@article{
author = "Dimitrijević, Mirjana and Stanojević, Stanislava and Vujić, Vesna and Kovačević-Jovanović, Vesna and Beck-Sickinger, A. and Demuth, H.U. and von Hoersten, Stephan",
year = "2002",
abstract = "Several lines of evidence suggest that neuropeptide Y (NPY) may exert regulatory effects in local inflammatory responses. Here, we show that intraplantarly (i.pl.) applied NPY, peptide YY (PYY), and an NPY Y5 receptor-selective agonist dose-dependently potentiate concanavalin A (Con A)-induced paw edema in the rat. The NPY Y1 receptor antagonist BIBO 3304 abolishes the pro-inflammatory action of both NPY and PYY while the dipeptidyl-peptidase IV (CD26) inhibitor Ile-thiazolidide exerted synergistic and potentiating effects in vivo. Taken together, the present data reveal an NPY Y1/Y5 receptor interplay and an involvement of CD26 in the NPY-induced potentiation of paw edema in the rat. (C) 2002 Elsevier Science B.V. All rights reserved.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Neuroimmunology",
title = "Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPYY1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26)",
pages = "42-35",
number = "1-2",
volume = "129",
doi = "10.1016/S0165-5728(02)00173-X"
}