Приказ основних података о документу

dc.creatorPopović, M.
dc.creatorCaballero-Bleda, M.
dc.creatorPuelles, L.
dc.creatorPopović, N.
dc.creatorPopović, N.
dc.date.accessioned2021-02-18T10:20:40Z
dc.date.available2021-02-18T10:20:40Z
dc.date.issued1998
dc.identifier.issn0020-7454
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/85
dc.description.abstractThe contribution of autoimmune processes or inflammatory components in the etiology and pathogenesis of Alzheimer's disease (AD) has been suspected for many years. The presence of antigen-presenting, HLA-DR-positive and other immunoregulatory cells, components of complement, inflammatory cytokines and acute phase reactants have been established in tissue of AD neuropathology. Although these data do not confirm the immune response as a primary cause of AD, they indicate involvement of immune processes at least as a secondary or tertiary reaction to the preexisting pathogen and point out its driving-force role in AD pathogenesis. These processes may contribute to systemic immune response. Thus, experimental and clinical studies indicate impairments in both humoral and cellular immunity in an animal model of AD as well as in AD patients. On the other hand, anti-inflammatory drugs applied for the treatment of some chronic inflammatory diseases have been shown to reduce risk of AD in these patients. Therefore, it seems that anti-inflammatory drugs and other substances which can control the activity of immunocompetent cells and the level of endogenous immune response can be valuable in the treatment of AD patients.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Neuroscience
dc.subjectAlzheimer's diseaseen
dc.subjectinflammationen
dc.subjectneuroimmunomodulationen
dc.subjecttherapyen
dc.titleImportance of immunological and inflammatory processes in the pathogenesis and therapy of Alzheimer's diseaseen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage236
dc.citation.issue3-4
dc.citation.other95(3-4): 203-236
dc.citation.rankM23
dc.citation.spage203
dc.citation.volume95
dc.identifier.doi10.3109/00207459809003341
dc.identifier.pmid9777440
dc.identifier.scopus2-s2.0-0032167787
dc.identifier.wos000076776300006
dc.type.versionpublishedVersion


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Приказ основних података о документу