Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat
Authorized Users Only
Article (Published version)
MetadataShow full item record
The present study was undertaken to elucidate whether electrolytic lesions of nucleus basalis magnocellularis-NBM (an animal model of Alzheimer's disease-AD) may influence humoral and cellular immune responses in adult male Wistar rats. For this purpose intact control (IC), sham-operated (SO) and NBM-lesioned rats were divided into two main groups: (1) rats immunized with sheep red blood cells (SRBC) for plaque-forming cell (PFC) response and anti-SRBC agglutinins, and (2) rats immunized with bovine serum albumin in complete Freund's adjuvant (BSA-CFA) for anti-BSA antibody production, Arthus and delayed hypersensitivity skin reaction to BSA. PFC responses and anti-SRBC agglutinins as well as diameter and expression of edema/induration of Arthus/delayed skin reaction and titer of anti-BSA antibody were significantly lower in NBM lesioned rats (compared to IC and SO). The results showed that in NBM-lesioned rats both the humoral and cellular immune responses were suppressed.
Keywords:nucleus basalis magnocellularis / brain lesions / plaque-forming cell response / Arthus reaction / delayed hypersensitivity / antibody production / rat
Source:International Journal of Neuroscience, 1997, 89, 3-4, 165-176
- Taylor & Francis Ltd, Abingdon