Open field behavior in nucleus basalis magnocellularis-lesioned rats treated with physostigmine and verapamil
Abstract
The present study was done to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.030, 0.045, 0.060 and 0.075 mg/kg sc) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc) on open field behavior in male Wistar rats with bilateral electrolytic lesions of nucleus basalis magnocellularis (NBM). NBM-lesions produced a significant increase and decrease of ambulation and number of inner squares entered, and defecation, respectively, with no influence on grooming in rats exposed to novel environment. Physostigmine and verapamil in all tested doses, given 30 min before the test did not affect the open field behavior in control animals. In contrast to that, physostigmine (0.045, 0.060 and 0.075 mg/kg) and verapamil (2.5 and 5.0 mg/kg) significantly reduced ambulation and number of inner squares entered in NBM-lesioned rats. Also, physostigmine in a dose of 0.060 mg/kg significantly decreased defecation and in doses of 0.060 and 0.075 mg/kg the groom...ing, as well. On the other hand, verapamil only in a dose of 2.5 mg/kg significantly increased defecation. It could be concluded that lesions of NBM in rats induced disturbances in the open field behavior, which might be successfully ameliorate by physostigmine and verapamil treatment.
Keywords:
Alzheimer's disease / nucleus basalis magnocellularis / open field / physostigmine / verapamil / ratsSource:
International Journal of Neuroscience, 1997, 91, 3-4, 181-188Publisher:
- Taylor & Francis Ltd, Abingdon
DOI: 10.3109/00207459708986375
ISSN: 0020-7454
PubMed: 9394225
WoS: A1997YE86000004
Scopus: 2-s2.0-0031259859
Collections
Institution/Community
TorlakTY - JOUR AU - Popović, M. AU - Popović, N. AU - Jovanova-Nešić, Katica AU - Bokonjić, D. AU - Dobrić, Silva AU - Rosić, N. PY - 1997 UR - http://intor.torlakinstitut.com/handle/123456789/77 AB - The present study was done to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.030, 0.045, 0.060 and 0.075 mg/kg sc) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc) on open field behavior in male Wistar rats with bilateral electrolytic lesions of nucleus basalis magnocellularis (NBM). NBM-lesions produced a significant increase and decrease of ambulation and number of inner squares entered, and defecation, respectively, with no influence on grooming in rats exposed to novel environment. Physostigmine and verapamil in all tested doses, given 30 min before the test did not affect the open field behavior in control animals. In contrast to that, physostigmine (0.045, 0.060 and 0.075 mg/kg) and verapamil (2.5 and 5.0 mg/kg) significantly reduced ambulation and number of inner squares entered in NBM-lesioned rats. Also, physostigmine in a dose of 0.060 mg/kg significantly decreased defecation and in doses of 0.060 and 0.075 mg/kg the grooming, as well. On the other hand, verapamil only in a dose of 2.5 mg/kg significantly increased defecation. It could be concluded that lesions of NBM in rats induced disturbances in the open field behavior, which might be successfully ameliorate by physostigmine and verapamil treatment. PB - Taylor & Francis Ltd, Abingdon T2 - International Journal of Neuroscience T1 - Open field behavior in nucleus basalis magnocellularis-lesioned rats treated with physostigmine and verapamil EP - 188 IS - 3-4 SP - 181 VL - 91 DO - 10.3109/00207459708986375 ER -
@article{ author = "Popović, M. and Popović, N. and Jovanova-Nešić, Katica and Bokonjić, D. and Dobrić, Silva and Rosić, N.", year = "1997", abstract = "The present study was done to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.030, 0.045, 0.060 and 0.075 mg/kg sc) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc) on open field behavior in male Wistar rats with bilateral electrolytic lesions of nucleus basalis magnocellularis (NBM). NBM-lesions produced a significant increase and decrease of ambulation and number of inner squares entered, and defecation, respectively, with no influence on grooming in rats exposed to novel environment. Physostigmine and verapamil in all tested doses, given 30 min before the test did not affect the open field behavior in control animals. In contrast to that, physostigmine (0.045, 0.060 and 0.075 mg/kg) and verapamil (2.5 and 5.0 mg/kg) significantly reduced ambulation and number of inner squares entered in NBM-lesioned rats. Also, physostigmine in a dose of 0.060 mg/kg significantly decreased defecation and in doses of 0.060 and 0.075 mg/kg the grooming, as well. On the other hand, verapamil only in a dose of 2.5 mg/kg significantly increased defecation. It could be concluded that lesions of NBM in rats induced disturbances in the open field behavior, which might be successfully ameliorate by physostigmine and verapamil treatment.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "International Journal of Neuroscience", title = "Open field behavior in nucleus basalis magnocellularis-lesioned rats treated with physostigmine and verapamil", pages = "188-181", number = "3-4", volume = "91", doi = "10.3109/00207459708986375" }
Popović, M., Popović, N., Jovanova-Nešić, K., Bokonjić, D., Dobrić, S.,& Rosić, N.. (1997). Open field behavior in nucleus basalis magnocellularis-lesioned rats treated with physostigmine and verapamil. in International Journal of Neuroscience Taylor & Francis Ltd, Abingdon., 91(3-4), 181-188. https://doi.org/10.3109/00207459708986375
Popović M, Popović N, Jovanova-Nešić K, Bokonjić D, Dobrić S, Rosić N. Open field behavior in nucleus basalis magnocellularis-lesioned rats treated with physostigmine and verapamil. in International Journal of Neuroscience. 1997;91(3-4):181-188. doi:10.3109/00207459708986375 .
Popović, M., Popović, N., Jovanova-Nešić, Katica, Bokonjić, D., Dobrić, Silva, Rosić, N., "Open field behavior in nucleus basalis magnocellularis-lesioned rats treated with physostigmine and verapamil" in International Journal of Neuroscience, 91, no. 3-4 (1997):181-188, https://doi.org/10.3109/00207459708986375 . .