Behavioral and adaptive status in an experimental model of Alzheimer's disease in rats
Само за регистроване кориснике
1996
Аутори
Popović, M.Jovanova-Nešić, Katica
Popović, N.
Bokonjić, D.
Dobrić, Silva
Rosić, N.
Rakić, L.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Ten days after bilateral electrolytic lesions of nucleus basalis magnocellularis (NBM) we tested behavioral (spontaneous motor activity, acquisition and performance of two-way active avoidance, fear-response in open field test, foot shock induced aggression, depression-response in learned helplessness test) and adaptive status (body temperature at standard, hot and cold environment as well as cold restraint-induced gastric lesions) in adult male Wistar rats. Compared to intact control and sham-operated rats, the bilateral NBM-lesioned rats showed the significant impairment of learning behavior and reduced fear, aggression and depression as well as altered body temperature at standard and stressed conditions. Namely, it was established that body temperature in NBM-lesioned rats was significantly lower at standard laboratory conditions, but in these rats body temperature significantly was raised after exposing to cold and hot environment. On the other hand, spontaneous motor activity and... number and length of cold restraint-induced gastric lesions (erosions and petechiae) in NBM-lesioned rats were similarly to those in both controls. It could be concluded that NBM plays a significant role in cognitive, emotional and adaptive processes in the rats.
Кључне речи:
Alzheimer's disease / active avoidance / spontaneous motor activity / open field / foot shock aggression / learned helplessness / body temperature / stress ulcer / ratИзвор:
International Journal of Neuroscience, 1996, 86, 3-4, 281-299Издавач:
- Taylor & Francis Ltd, Abingdon
DOI: 10.3109/00207459608986719
ISSN: 0020-7454
PubMed: 8884399
WoS: A1996VH70300012
Scopus: 2-s2.0-0030239457
Институција/група
TorlakTY - JOUR AU - Popović, M. AU - Jovanova-Nešić, Katica AU - Popović, N. AU - Bokonjić, D. AU - Dobrić, Silva AU - Rosić, N. AU - Rakić, L. PY - 1996 UR - http://intor.torlakinstitut.com/handle/123456789/66 AB - Ten days after bilateral electrolytic lesions of nucleus basalis magnocellularis (NBM) we tested behavioral (spontaneous motor activity, acquisition and performance of two-way active avoidance, fear-response in open field test, foot shock induced aggression, depression-response in learned helplessness test) and adaptive status (body temperature at standard, hot and cold environment as well as cold restraint-induced gastric lesions) in adult male Wistar rats. Compared to intact control and sham-operated rats, the bilateral NBM-lesioned rats showed the significant impairment of learning behavior and reduced fear, aggression and depression as well as altered body temperature at standard and stressed conditions. Namely, it was established that body temperature in NBM-lesioned rats was significantly lower at standard laboratory conditions, but in these rats body temperature significantly was raised after exposing to cold and hot environment. On the other hand, spontaneous motor activity and number and length of cold restraint-induced gastric lesions (erosions and petechiae) in NBM-lesioned rats were similarly to those in both controls. It could be concluded that NBM plays a significant role in cognitive, emotional and adaptive processes in the rats. PB - Taylor & Francis Ltd, Abingdon T2 - International Journal of Neuroscience T1 - Behavioral and adaptive status in an experimental model of Alzheimer's disease in rats EP - 299 IS - 3-4 SP - 281 VL - 86 DO - 10.3109/00207459608986719 ER -
@article{ author = "Popović, M. and Jovanova-Nešić, Katica and Popović, N. and Bokonjić, D. and Dobrić, Silva and Rosić, N. and Rakić, L.", year = "1996", abstract = "Ten days after bilateral electrolytic lesions of nucleus basalis magnocellularis (NBM) we tested behavioral (spontaneous motor activity, acquisition and performance of two-way active avoidance, fear-response in open field test, foot shock induced aggression, depression-response in learned helplessness test) and adaptive status (body temperature at standard, hot and cold environment as well as cold restraint-induced gastric lesions) in adult male Wistar rats. Compared to intact control and sham-operated rats, the bilateral NBM-lesioned rats showed the significant impairment of learning behavior and reduced fear, aggression and depression as well as altered body temperature at standard and stressed conditions. Namely, it was established that body temperature in NBM-lesioned rats was significantly lower at standard laboratory conditions, but in these rats body temperature significantly was raised after exposing to cold and hot environment. On the other hand, spontaneous motor activity and number and length of cold restraint-induced gastric lesions (erosions and petechiae) in NBM-lesioned rats were similarly to those in both controls. It could be concluded that NBM plays a significant role in cognitive, emotional and adaptive processes in the rats.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "International Journal of Neuroscience", title = "Behavioral and adaptive status in an experimental model of Alzheimer's disease in rats", pages = "299-281", number = "3-4", volume = "86", doi = "10.3109/00207459608986719" }
Popović, M., Jovanova-Nešić, K., Popović, N., Bokonjić, D., Dobrić, S., Rosić, N.,& Rakić, L.. (1996). Behavioral and adaptive status in an experimental model of Alzheimer's disease in rats. in International Journal of Neuroscience Taylor & Francis Ltd, Abingdon., 86(3-4), 281-299. https://doi.org/10.3109/00207459608986719
Popović M, Jovanova-Nešić K, Popović N, Bokonjić D, Dobrić S, Rosić N, Rakić L. Behavioral and adaptive status in an experimental model of Alzheimer's disease in rats. in International Journal of Neuroscience. 1996;86(3-4):281-299. doi:10.3109/00207459608986719 .
Popović, M., Jovanova-Nešić, Katica, Popović, N., Bokonjić, D., Dobrić, Silva, Rosić, N., Rakić, L., "Behavioral and adaptive status in an experimental model of Alzheimer's disease in rats" in International Journal of Neuroscience, 86, no. 3-4 (1996):281-299, https://doi.org/10.3109/00207459608986719 . .