Fatty acid profiling in amyotrophic lateral sclerosis
Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, affecting motor neurons, which is characterized by the progressive loss of motor function. Sufficient evidence has been gathered, either in the form of experimental results from animal disease models or from the assessment of affected human subjects, which implicates metabolic changes in the course of ALS. Hypermetabolism, abnormal glucose tolerance and dyslipidaemia were reported to have high incidence in ALS patients. In fact, according to published studies, BMI is significantly and inversely associated with ALS progression. Here, we discuss basic principles of fatty acid metabolism, composition and the existing knowledge of metabolic and fatty acid composition changes in ALS patients. Literature data suggest that ALS patients have unfavorable changes in the fatty acid profile, especially because of the low level of long-chain polyunsaturated fatty acids. Nutritional interventions and supplementation with vario...us foods or food supplements are currently not showing conclusive results, implying there is more to learn about potential ways to modify this illness.
Keywords:
Amyotrophic lateral sclerosis / Neurodegeneration / Fatty acids / Polyunsaturated fatty acids / β-oxidationSource:
Diet and Nutrition in Neurological Disorders, 2023, 155-172Publisher:
- Elsevier
Funding / projects:
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200015 (University of Belgrade, Institute for Medical Research) (RS-200015)
- The effects of homocysteine and homocysteine-related compounds on cardiovascular system: role of gaseous transmitters No, H2S and CO (RS-175043)
- Biomarkers in neurodegenerative and malignant processes (RS-41005)
- Research on molecular-genetic, pathohistological and biochemical characteristics of neuromuscular disorders (RS-175083)
DOI: 10.1016/B978-0-323-89834-8.00023-4
ISBN: 978-0-323-89834-8
Scopus: 2-s2.0-85166123814
Collections
Institution/Community
TorlakTY - CHAP AU - Minić, Rajna AU - Stević, Zorica AU - Arsić, Aleksandra. PY - 2023 UR - http://intor.torlakinstitut.com/handle/123456789/656 AB - Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, affecting motor neurons, which is characterized by the progressive loss of motor function. Sufficient evidence has been gathered, either in the form of experimental results from animal disease models or from the assessment of affected human subjects, which implicates metabolic changes in the course of ALS. Hypermetabolism, abnormal glucose tolerance and dyslipidaemia were reported to have high incidence in ALS patients. In fact, according to published studies, BMI is significantly and inversely associated with ALS progression. Here, we discuss basic principles of fatty acid metabolism, composition and the existing knowledge of metabolic and fatty acid composition changes in ALS patients. Literature data suggest that ALS patients have unfavorable changes in the fatty acid profile, especially because of the low level of long-chain polyunsaturated fatty acids. Nutritional interventions and supplementation with various foods or food supplements are currently not showing conclusive results, implying there is more to learn about potential ways to modify this illness. PB - Elsevier T2 - Diet and Nutrition in Neurological Disorders T1 - Fatty acid profiling in amyotrophic lateral sclerosis EP - 172 SP - 155 DO - 10.1016/B978-0-323-89834-8.00023-4 ER -
@inbook{ author = "Minić, Rajna and Stević, Zorica and Arsić, Aleksandra.", year = "2023", abstract = "Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, affecting motor neurons, which is characterized by the progressive loss of motor function. Sufficient evidence has been gathered, either in the form of experimental results from animal disease models or from the assessment of affected human subjects, which implicates metabolic changes in the course of ALS. Hypermetabolism, abnormal glucose tolerance and dyslipidaemia were reported to have high incidence in ALS patients. In fact, according to published studies, BMI is significantly and inversely associated with ALS progression. Here, we discuss basic principles of fatty acid metabolism, composition and the existing knowledge of metabolic and fatty acid composition changes in ALS patients. Literature data suggest that ALS patients have unfavorable changes in the fatty acid profile, especially because of the low level of long-chain polyunsaturated fatty acids. Nutritional interventions and supplementation with various foods or food supplements are currently not showing conclusive results, implying there is more to learn about potential ways to modify this illness.", publisher = "Elsevier", journal = "Diet and Nutrition in Neurological Disorders", booktitle = "Fatty acid profiling in amyotrophic lateral sclerosis", pages = "172-155", doi = "10.1016/B978-0-323-89834-8.00023-4" }
Minić, R., Stević, Z.,& Arsić, Aleksandra.. (2023). Fatty acid profiling in amyotrophic lateral sclerosis. in Diet and Nutrition in Neurological Disorders Elsevier., 155-172. https://doi.org/10.1016/B978-0-323-89834-8.00023-4
Minić R, Stević Z, Arsić A. Fatty acid profiling in amyotrophic lateral sclerosis. in Diet and Nutrition in Neurological Disorders. 2023;:155-172. doi:10.1016/B978-0-323-89834-8.00023-4 .
Minić, Rajna, Stević, Zorica, Arsić, Aleksandra., "Fatty acid profiling in amyotrophic lateral sclerosis" in Diet and Nutrition in Neurological Disorders (2023):155-172, https://doi.org/10.1016/B978-0-323-89834-8.00023-4 . .