Age and gender associated changes in immunoglobulin subclass levels specific to S. pneumoniae, serotype 1
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2022
Authors
Knežević, SanjaKosanović, Dejana

Dragačević, Luka

Živković, Irena

Ilić, Vesna

Hajduković, Ljiljana
Savić, Olivera
Minić, Rajna

Article (Published version)

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S. pneumoniae is an important human pathogen which has a polysaccharide capsule with virulent properties. This work aims to estimate the titres of S. pneumoniae specific IgG and IgA isotypes, with respect to age and sex. An in-house whole bacterial cell ELISA was used for the determination of relative levels and endpoint titres of IgG subclasses and IgA1 subclass specific for S. pneumoniae serogroup 1, and to quantify specific IgG1 and IgG2 levels. Significantly lower anti-pneumococcus IgG1 titres were found in older individuals, which was more pronounced in men. Lower IgG2 titres were detected in men over 50 years of age, in comparison to women under 50 years of age. The levels of IgG3 and IgG4 did not differ between different sex and age groups. Lower IgA1 levels were detected in male individuals in both age groups in comparison to females under 50 years of age. The levels of IgG1 showed a moderate correlation with IgG4 in younger individuals of both sexes (r = 0.61 in men and 0.63 i...n women) which was not noted in the older age group. We highlight the deficiency in humoral immunity in older people, especially male and suggest immunization of this population with pneumococcal vaccines.
Keywords:
Ageing / Anti-bacterial antibodies / Anti-pneumococcus antibodies / Sex characteristicsSource:
Comparative Immunology, Microbiology and Infectious Diseases, 2022, 87, 101834-Publisher:
- Elsevier
Funding / projects:
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200177 (Immunology Research Centre 'Branislav Janković' Torlak, Belgrade) (RS-200177)
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200015 (University of Belgrade, Institute for Medical Research) (RS-200015)
Note:
- Peer reviewed version: https://intor.torlakinstitut.com/handle/123456789/651
DOI: 10.1016/j.cimid.2022.101834
ISSN: 0147-9571
WoS: 00081851650000
Scopus: 2-s2.0-85132231545
URI
http://rimi.imi.bg.ac.rs/handle/123456789/1255http://intor.torlakinstitut.com/handle/123456789/650
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TorlakTY - JOUR AU - Knežević, Sanja AU - Kosanović, Dejana AU - Dragačević, Luka AU - Živković, Irena AU - Ilić, Vesna AU - Hajduković, Ljiljana AU - Savić, Olivera AU - Minić, Rajna PY - 2022 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1255 UR - http://intor.torlakinstitut.com/handle/123456789/650 AB - S. pneumoniae is an important human pathogen which has a polysaccharide capsule with virulent properties. This work aims to estimate the titres of S. pneumoniae specific IgG and IgA isotypes, with respect to age and sex. An in-house whole bacterial cell ELISA was used for the determination of relative levels and endpoint titres of IgG subclasses and IgA1 subclass specific for S. pneumoniae serogroup 1, and to quantify specific IgG1 and IgG2 levels. Significantly lower anti-pneumococcus IgG1 titres were found in older individuals, which was more pronounced in men. Lower IgG2 titres were detected in men over 50 years of age, in comparison to women under 50 years of age. The levels of IgG3 and IgG4 did not differ between different sex and age groups. Lower IgA1 levels were detected in male individuals in both age groups in comparison to females under 50 years of age. The levels of IgG1 showed a moderate correlation with IgG4 in younger individuals of both sexes (r = 0.61 in men and 0.63 in women) which was not noted in the older age group. We highlight the deficiency in humoral immunity in older people, especially male and suggest immunization of this population with pneumococcal vaccines. PB - Elsevier T2 - Comparative Immunology, Microbiology and Infectious Diseases T1 - Age and gender associated changes in immunoglobulin subclass levels specific to S. pneumoniae, serotype 1 SP - 101834 VL - 87 DO - 10.1016/j.cimid.2022.101834 ER -
@article{ author = "Knežević, Sanja and Kosanović, Dejana and Dragačević, Luka and Živković, Irena and Ilić, Vesna and Hajduković, Ljiljana and Savić, Olivera and Minić, Rajna", year = "2022", abstract = "S. pneumoniae is an important human pathogen which has a polysaccharide capsule with virulent properties. This work aims to estimate the titres of S. pneumoniae specific IgG and IgA isotypes, with respect to age and sex. An in-house whole bacterial cell ELISA was used for the determination of relative levels and endpoint titres of IgG subclasses and IgA1 subclass specific for S. pneumoniae serogroup 1, and to quantify specific IgG1 and IgG2 levels. Significantly lower anti-pneumococcus IgG1 titres were found in older individuals, which was more pronounced in men. Lower IgG2 titres were detected in men over 50 years of age, in comparison to women under 50 years of age. The levels of IgG3 and IgG4 did not differ between different sex and age groups. Lower IgA1 levels were detected in male individuals in both age groups in comparison to females under 50 years of age. The levels of IgG1 showed a moderate correlation with IgG4 in younger individuals of both sexes (r = 0.61 in men and 0.63 in women) which was not noted in the older age group. We highlight the deficiency in humoral immunity in older people, especially male and suggest immunization of this population with pneumococcal vaccines.", publisher = "Elsevier", journal = "Comparative Immunology, Microbiology and Infectious Diseases", title = "Age and gender associated changes in immunoglobulin subclass levels specific to S. pneumoniae, serotype 1", pages = "101834", volume = "87", doi = "10.1016/j.cimid.2022.101834" }
Knežević, S., Kosanović, D., Dragačević, L., Živković, I., Ilić, V., Hajduković, L., Savić, O.,& Minić, R.. (2022). Age and gender associated changes in immunoglobulin subclass levels specific to S. pneumoniae, serotype 1. in Comparative Immunology, Microbiology and Infectious Diseases Elsevier., 87, 101834. https://doi.org/10.1016/j.cimid.2022.101834
Knežević S, Kosanović D, Dragačević L, Živković I, Ilić V, Hajduković L, Savić O, Minić R. Age and gender associated changes in immunoglobulin subclass levels specific to S. pneumoniae, serotype 1. in Comparative Immunology, Microbiology and Infectious Diseases. 2022;87:101834. doi:10.1016/j.cimid.2022.101834 .
Knežević, Sanja, Kosanović, Dejana, Dragačević, Luka, Živković, Irena, Ilić, Vesna, Hajduković, Ljiljana, Savić, Olivera, Minić, Rajna, "Age and gender associated changes in immunoglobulin subclass levels specific to S. pneumoniae, serotype 1" in Comparative Immunology, Microbiology and Infectious Diseases, 87 (2022):101834, https://doi.org/10.1016/j.cimid.2022.101834 . .