Effects of water-filtered infrared A and visible light (wIRA/VIS) radiation on heat- and stress-responsive proteins in the retina and cornea of guinea pigs
2021
Преузимање 🢃
Аутори
Frohns, AntoniaStojanović, Marijana
Barisani-Asenbauer, Talin
Kuratli, Jasmin
Borel, Nicole
Inić-Kanada, Aleksandra
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Water-filtered infrared A and visible light (wIRA/VIS), shown to reduce chlamydial infections in vitro and in vivo, might represent an innovative therapeutic approach against trachoma, a neglected tropical disease caused by ocular infection with the bacterium C. trachomatis. In this in vivo study, we assessed the impact of wIRA radiation in combination with VIS (wavelength range 595–1400 nm, intensity 2100 W/m2) on the retina and cornea in a guinea pig animal model of inclusion conjunctivitis. We investigated the effects 19 days after wIRA/VIS irradiation by comparing a single and double wIRA/VIS treatment with a sham control. By immunolabeling and western blot analyses of critical heat- and stress-responsive proteins, we could not detect wIRA/VIS-induced changes in their expression pattern. Also, immunolabeling of specific retinal marker proteins revealed no changes in their expression pattern caused by the treatment. Our preclinical study suggests wIRA/VIS as a promising and safe the...rapeutic tool to treat ocular chlamydial infections.
Кључне речи:
Cornea / guinea pig / Retina / wIRA/VISИзвор:
Journal of Photochemistry and Photobiology B: Biology, 2021, 224, 112306-Издавач:
- Elsevier
Напомена:
- Supplementary information: https://hdl.handle.net/21.15107/rcub_intor_639
Повезане информације:
- Повезани садржај
https://hdl.handle.net/21.15107/rcub_intor_639
DOI: 10.1016/j.jphotobiol.2021.112306
ISSN: 1011-1344
WoS: 000707637900005
Scopus: 2-s2.0-85115741949
Институција/група
TorlakTY - JOUR AU - Frohns, Antonia AU - Stojanović, Marijana AU - Barisani-Asenbauer, Talin AU - Kuratli, Jasmin AU - Borel, Nicole AU - Inić-Kanada, Aleksandra PY - 2021 UR - http://intor.torlakinstitut.com/handle/123456789/617 AB - Water-filtered infrared A and visible light (wIRA/VIS), shown to reduce chlamydial infections in vitro and in vivo, might represent an innovative therapeutic approach against trachoma, a neglected tropical disease caused by ocular infection with the bacterium C. trachomatis. In this in vivo study, we assessed the impact of wIRA radiation in combination with VIS (wavelength range 595–1400 nm, intensity 2100 W/m2) on the retina and cornea in a guinea pig animal model of inclusion conjunctivitis. We investigated the effects 19 days after wIRA/VIS irradiation by comparing a single and double wIRA/VIS treatment with a sham control. By immunolabeling and western blot analyses of critical heat- and stress-responsive proteins, we could not detect wIRA/VIS-induced changes in their expression pattern. Also, immunolabeling of specific retinal marker proteins revealed no changes in their expression pattern caused by the treatment. Our preclinical study suggests wIRA/VIS as a promising and safe therapeutic tool to treat ocular chlamydial infections. PB - Elsevier T2 - Journal of Photochemistry and Photobiology B: Biology T1 - Effects of water-filtered infrared A and visible light (wIRA/VIS) radiation on heat- and stress-responsive proteins in the retina and cornea of guinea pigs SP - 112306 VL - 224 DO - 10.1016/j.jphotobiol.2021.112306 ER -
@article{ author = "Frohns, Antonia and Stojanović, Marijana and Barisani-Asenbauer, Talin and Kuratli, Jasmin and Borel, Nicole and Inić-Kanada, Aleksandra", year = "2021", abstract = "Water-filtered infrared A and visible light (wIRA/VIS), shown to reduce chlamydial infections in vitro and in vivo, might represent an innovative therapeutic approach against trachoma, a neglected tropical disease caused by ocular infection with the bacterium C. trachomatis. In this in vivo study, we assessed the impact of wIRA radiation in combination with VIS (wavelength range 595–1400 nm, intensity 2100 W/m2) on the retina and cornea in a guinea pig animal model of inclusion conjunctivitis. We investigated the effects 19 days after wIRA/VIS irradiation by comparing a single and double wIRA/VIS treatment with a sham control. By immunolabeling and western blot analyses of critical heat- and stress-responsive proteins, we could not detect wIRA/VIS-induced changes in their expression pattern. Also, immunolabeling of specific retinal marker proteins revealed no changes in their expression pattern caused by the treatment. Our preclinical study suggests wIRA/VIS as a promising and safe therapeutic tool to treat ocular chlamydial infections.", publisher = "Elsevier", journal = "Journal of Photochemistry and Photobiology B: Biology", title = "Effects of water-filtered infrared A and visible light (wIRA/VIS) radiation on heat- and stress-responsive proteins in the retina and cornea of guinea pigs", pages = "112306", volume = "224", doi = "10.1016/j.jphotobiol.2021.112306" }
Frohns, A., Stojanović, M., Barisani-Asenbauer, T., Kuratli, J., Borel, N.,& Inić-Kanada, A.. (2021). Effects of water-filtered infrared A and visible light (wIRA/VIS) radiation on heat- and stress-responsive proteins in the retina and cornea of guinea pigs. in Journal of Photochemistry and Photobiology B: Biology Elsevier., 224, 112306. https://doi.org/10.1016/j.jphotobiol.2021.112306
Frohns A, Stojanović M, Barisani-Asenbauer T, Kuratli J, Borel N, Inić-Kanada A. Effects of water-filtered infrared A and visible light (wIRA/VIS) radiation on heat- and stress-responsive proteins in the retina and cornea of guinea pigs. in Journal of Photochemistry and Photobiology B: Biology. 2021;224:112306. doi:10.1016/j.jphotobiol.2021.112306 .
Frohns, Antonia, Stojanović, Marijana, Barisani-Asenbauer, Talin, Kuratli, Jasmin, Borel, Nicole, Inić-Kanada, Aleksandra, "Effects of water-filtered infrared A and visible light (wIRA/VIS) radiation on heat- and stress-responsive proteins in the retina and cornea of guinea pigs" in Journal of Photochemistry and Photobiology B: Biology, 224 (2021):112306, https://doi.org/10.1016/j.jphotobiol.2021.112306 . .