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dc.creatorObradović, Ana
dc.creatorMatić, Miloš
dc.creatorOgnjanović, Branka
dc.creatorĐurđević, Predrag
dc.creatorMarinković, Emilija
dc.creatorUšćumlić, Gordana
dc.creatorBožić, Bojan
dc.creatorBožić-Nedeljković, Biljana
dc.date.accessioned2021-02-18T10:53:50Z
dc.date.available2021-02-18T10:53:50Z
dc.date.issued2020
dc.identifier.issn1319-0164
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/566
dc.description.abstractIn this study, a series of synthesized 3-(4-substituted benzyl)-5-isopropyl-5-phenylhydantoin derivatives as a potential antiproliferative and antimigratory agents were investigated. The possible antitumor mechanisms of investigated hydantoin derivatives were examined on human breast cancer cell line MDA-MB-231. The cells were treated with different concentrations of compounds (from 0.01 mu M to 100 mu M) during 24 h and 72 h. The proliferation index, nitric oxide production, apoptosis rate, and migration capacity were measured. The cell invasion potential was examined by measuring the level of MMP-9 and COX-2 gene expression. All tested compounds expressed antiproliferative activity and induced dose- and time-dependent increase in the level of nitrites. The investigated molecules significantly decreased cell survival rate, migration capacity and the expression levels of genes included in the process of tumor invasion. Obtained data suggest that the tested hydantoin derivatives express considerable antitumor activity by reducing cell division rate, elevating apoptosis level, and inhibiting the motility and invasiveness of breast cancer cells. The results obtained in this study indicate that investigated compounds express potential as a novel chemotherapeutic agents against breast cancer growth and progression. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.en
dc.publisherElsevier, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41010/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175033/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173041/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceSaudi Pharmaceutical Journal
dc.subjectHydantoin derivativesen
dc.subjectBreast cancer cell line MDA-MB-231en
dc.subjectProliferationen
dc.subjectApoptosisen
dc.subjectCell motilityen
dc.subjectNitric oxideen
dc.titleAntiproliferative and antimigratory effects of 3-(4-substituted benzyl)-5-isopropyl-5-phenylhydantoin derivatives in human breast cancer cellsen
dc.typearticle
dc.rights.licenseBY-NC-ND
dc.citation.epage254
dc.citation.issue3
dc.citation.other28(3): 246-254
dc.citation.rankM22
dc.citation.spage246
dc.citation.volume28
dc.identifier.doi10.1016/j.jsps.2020.01.003
dc.identifier.fulltexthttp://intor.torlakinstitut.com/bitstream/id/378/563.pdf
dc.identifier.pmid32194325
dc.identifier.rcubconv_472
dc.identifier.scopus2-s2.0-85079047354
dc.identifier.wos000520023600003
dc.type.versionpublishedVersion


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