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Sex differences in Tfh cell help to B cells contribute to sexual dimorphism in severity of rat collagen-induced arthritis
dc.creator | Dimitrijević, Mirjana | |
dc.creator | Arsenović-Ranin, Nevena | |
dc.creator | Kosec, Duško | |
dc.creator | Bufan, Biljana | |
dc.creator | Nacka-Aleksić, Mirjana | |
dc.creator | Pilipović, Ivan | |
dc.creator | Leposavić, Gordana | |
dc.date.accessioned | 2021-02-18T10:52:59Z | |
dc.date.available | 2021-02-18T10:52:59Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/554 | |
dc.description.abstract | The study examined germinal centre (GC) reaction in lymph nodes draining inflamed joints and adjacent tissues (dLNs) in male and female Dark Agouti rat collagen type II (CII)-induced arthritis (CIA) model of rheumatoid arthritis. Female rats exhibiting the greater susceptibility to CIA mounted stronger serum CII-specific IgG response than their male counterparts. This correlated with the higher frequency of GC B cells in female compared with male dLNs. Consistently, the frequency of activated/proliferating Ki-67+ cells among dLN B cells was higher in females than in males. This correlated with the shift in dLN T follicular regulatory (Tfr)/T follicular helper (Tfh) cell ratio towards Tfh cells in females, and greater densities of CD40L and CD40 on their dLN T and B cells, respectively. The higher Tfh cell frequency in females was consistent with the greater dLN expression of mRNA for IL-21/27, the key cytokines involved in Tfh cell generation and their help to B cells. Additionally, in CII-stimulated female rat dLN cell cultures IFN-gamma /IL-4 production ratio was shifted towards IFN-gamma. Consistently, the serum IgG2a(b)/IgG1 CII-specific antibody ratio was shifted towards an IgG2a(b) response in females. Thus, targeting T-/B-cell interactions should be considered in putative further sex-based translational pharmacology research. | en |
dc.publisher | Nature Publishing Group, London | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scientific Reports | |
dc.title | Sex differences in Tfh cell help to B cells contribute to sexual dimorphism in severity of rat collagen-induced arthritis | en |
dc.type | article | |
dc.rights.license | BY | |
dc.citation.issue | 1 | |
dc.citation.other | 10(1) | |
dc.citation.rank | M21 | |
dc.citation.volume | 10 | |
dc.identifier.doi | 10.1038/s41598-020-58127-y | |
dc.identifier.fulltext | http://intor.torlakinstitut.com/bitstream/id/367/551.pdf | |
dc.identifier.pmid | 31988383 | |
dc.identifier.scopus | 2-s2.0-85078337543 | |
dc.identifier.wos | 000559995900005 | |
dc.type.version | publishedVersion |