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dc.creatorArsenović-Ranin, Nevena
dc.creatorPetrović, Raisa
dc.creatorŽivković, Irena
dc.creatorBufan, Biljana
dc.creatorStoiljković, Vera
dc.creatorLeposavić, Gordana
dc.date.accessioned2021-02-18T10:51:33Z
dc.date.available2021-02-18T10:51:33Z
dc.date.issued2019
dc.identifier.issn1389-5729
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/534
dc.description.abstractThe study examined sex-specificities in age-related changes in BALB/c mice IgG antibody responses to immunisation with trivalent inactivated split-virus influenza bulk. Aging diminished the total serum IgG antibody responses to H1N1 and H3N2 and B influenza virus antigens in mice of both sexes, but they remained greater in aged females. This sex difference in aged mice correlated with the greater post-immunisation increase in the frequency of spleen germinal centre (GC) B cells and more favourable T follicular regulatory (Tfr)/GC B cell ratio, as Tfr cells are suggested to control antibody production through suppression of glycolysis. The greater post-immunisation GC B cell response in aged females compared with males correlated with the greater proliferation of B cells and CD4+ cells in splenocyte cultures from aged females restimulated with inactivated split-virus influenza from the bulk. To support the greater post-immunisation increase in the frequency GC B cell in aged females was more favourable Tfr/T follicular helper (Tfh) cell ratio. Additionally, compared with aged males, in age-matched females the greater avidity of serum IgG antibodies was found. However, in aged females IgG2a/IgG1 antibody ratio, reflecting spleen Th1/Th2 cytokine balance, was shifted towards IgG1 when compared with age-matched male mice. This shift was ascribed to a more prominent decline in the titres of functionally important IgG2a antibodies in females with aging. The study suggest that biological sex should be considered as a variable in designing strategies to manipulate with immune outcome of immunisation in aged animals, and possibly, at very long distance, humans.en
dc.publisherSpringer, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsrestrictedAccess
dc.sourceBiogerontology
dc.subjectAgingen
dc.subjectSex differencesen
dc.subjectInfluenza vaccineen
dc.subjectIgG antibody avidityen
dc.subjectIgG2aen
dc.subjectIgG1 ratioen
dc.subjectTfren
dc.subjectTfh cell ratioen
dc.titleInfluence of aging on germinal centre reaction and antibody response to inactivated influenza virus antigens in mice: sex-based differencesen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage496
dc.citation.issue4
dc.citation.other20(4): 475-496
dc.citation.rankM21
dc.citation.spage475
dc.citation.volume20
dc.identifier.doi10.1007/s10522-019-09811-8
dc.identifier.pmid31049769
dc.identifier.scopus2-s2.0-85065293816
dc.identifier.wos000472839400008
dc.type.versionpublishedVersion


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