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dc.creatorStanojević, Stanislava
dc.creatorBlagojević, Veljko
dc.creatorĆuruvija, Ivana
dc.creatorVeljović, Katarina
dc.creatorSoković-Bajić, Svetlana
dc.creatorKotur-Stevuljević, Jelena
dc.creatorBogdanović, Andrija
dc.creatorPetrović, Raisa
dc.creatorVujnović, Ivana
dc.creatorKovačević-Jovanović, Vesna
dc.date.accessioned2021-02-18T10:49:36Z
dc.date.available2021-02-18T10:49:36Z
dc.date.issued2018
dc.identifier.issn1756-4646
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/505
dc.description.abstractThe current study investigated a potential modulating effect of orally applied Lactobacillus rhamnosus 64 (LB64) during the early postnatal period (day of life: similar to 3-30), during young adult period (day of life: 31-70) or throughout experiment, on parameters of trinitrobenzenesulfonic acid (TNBS)-induced colitis in adult rats. Treatment with LB64 during early postnatal, but not during young adult period reduced clinical damage score, neutrophil and macrophage infiltration into colon, the level of cytokine and myeloperoxidase (MPO) activity, but had no influence on other parameters of oxidative damage. Early postnatal treatment with LB64 also increased the diversity of fecal Bifidobacteria and Eubacteria, and improved maturation of ileal villi in 30-days old rats. When LB64 is applied during a critical period early in life, it affects immune system functioning of adults, probably by interactions with the mucosal immune system of the gastrointestinal tract that provides immune system maturation and shapes the overall immune response.en
dc.publisherElsevier Science Bv, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Functional Foods
dc.subjectLactobacillus rhamnosus 64en
dc.subjectEarly postnatal treatmenten
dc.subjectMicrobiota diversityen
dc.subjectRatsen
dc.subjectTNBS-induced colitisen
dc.titleOral treatment with Lactobacillus rhamnosus 64 during the early postnatal period improves the health of adult rats with TNBS-induced colitisen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage105
dc.citation.other48: 92-105
dc.citation.rankM21
dc.citation.spage92
dc.citation.volume48
dc.identifier.doi10.1016/j.jff.2018.07.014
dc.identifier.rcubconv_442
dc.identifier.scopus2-s2.0-85049437192
dc.identifier.wos000447573600010
dc.type.versionpublishedVersion


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