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dc.creatorTomić-Spirić, Vesna
dc.creatorDizdarević, Denisa
dc.creatorJanković, Slavenka
dc.creatorBurazer, Lidija
dc.creatorBarac, Aleksandra
dc.creatorBolpacić, Jasna
dc.creatorĐurić, Vojislav
dc.creatorPerić-Popadić, Aleksandra
dc.creatorAleksić, Aleksandra
dc.creatorBogić, Mirjana
dc.date.accessioned2021-02-18T10:47:32Z
dc.date.available2021-02-18T10:47:32Z
dc.date.issued2016
dc.identifier.issn1735-1502
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/474
dc.description.abstractSublingual allergen immunotherapy (SLIT) is considered to be safer and more convenient than subcutaneus immunotherapy. SLIT trials with house dust mites involving patients with allergic rhinitis (AR) and asthma reported discordant results. The aim of the study was to investigate the clinical efficacy and safety of SLIT with Dermatophagoides pteronyssinus (D.pt) extract produced in Serbia and patient's satisfaction through open-label trial. Adult patients with allergic rhinitis were randomized into two groups: one received drugs and SLIT, while other received only drugs. Symptom score (SS), medication score (MS) and cumulative score (CS), skin prick tests (SPT) and serum level of D. pt specific IgE were assessed. One year after, the patients were re-evaluated. In total, 61 patients were enrolled in the study, but 52 of them were analyzed at the end of the year. CS (29.3%, p lt 0.001) and MS (54.3%, p lt 0.05) reduced significantly in the SLIT group. There was a significant improvement of MS and CS in the SLIT compared to control group (p lt 0.001 and p lt 0.05 respectively). There was no significant improvement of SS as well as specific slgE. Patients in the SLIT group were more satisfied with treatment (p lt 0.001). The incidence of mild adverse reaction was 38.4%. Specific lgG was not done. One year SLIT with D. pt extract was clinically efficient treatment in AR patients.en
dc.publisherTehran Univ Medical Sciences, Tehran
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175025/RS//
dc.rightsopenAccess
dc.sourceIranian Journal of Allergy, Asthma and Immunology
dc.subjectAllergic rhinitisen
dc.subjectAsthmaen
dc.subjectDermatophagoides pteronyssinusen
dc.subjectEfficacyen
dc.subjectSublingual immunotherapyen
dc.titleEfficacy of Sublingual Immunotherapy with Dermatophagoides Pteronyssinus: A Real-life Studyen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage121
dc.citation.issue2
dc.citation.other15(2): 112-121
dc.citation.rankM23
dc.citation.spage112
dc.citation.volume15
dc.identifier.pmid27090364
dc.identifier.rcubconv_388
dc.identifier.scopus2-s2.0-84964068299
dc.identifier.wos000377774800003
dc.type.versionpublishedVersion


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