Efficacy of Sublingual Immunotherapy with Dermatophagoides Pteronyssinus: A Real-life Study
Authors
Tomić-Spirić, VesnaDizdarević, Denisa
Janković, Slavenka
Burazer, Lidija
Barac, Aleksandra
Bolpacić, Jasna
Đurić, Vojislav
Perić-Popadić, Aleksandra
Aleksić, Aleksandra
Bogić, Mirjana
Article (Published version)
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Sublingual allergen immunotherapy (SLIT) is considered to be safer and more convenient than subcutaneus immunotherapy. SLIT trials with house dust mites involving patients with allergic rhinitis (AR) and asthma reported discordant results. The aim of the study was to investigate the clinical efficacy and safety of SLIT with Dermatophagoides pteronyssinus (D.pt) extract produced in Serbia and patient's satisfaction through open-label trial. Adult patients with allergic rhinitis were randomized into two groups: one received drugs and SLIT, while other received only drugs. Symptom score (SS), medication score (MS) and cumulative score (CS), skin prick tests (SPT) and serum level of D. pt specific IgE were assessed. One year after, the patients were re-evaluated. In total, 61 patients were enrolled in the study, but 52 of them were analyzed at the end of the year. CS (29.3%, p lt 0.001) and MS (54.3%, p lt 0.05) reduced significantly in the SLIT group. There was a significant improvement... of MS and CS in the SLIT compared to control group (p lt 0.001 and p lt 0.05 respectively). There was no significant improvement of SS as well as specific slgE. Patients in the SLIT group were more satisfied with treatment (p lt 0.001). The incidence of mild adverse reaction was 38.4%. Specific lgG was not done. One year SLIT with D. pt extract was clinically efficient treatment in AR patients.
Keywords:
Allergic rhinitis / Asthma / Dermatophagoides pteronyssinus / Efficacy / Sublingual immunotherapySource:
Iranian Journal of Allergy, Asthma and Immunology, 2016, 15, 2, 112-121Publisher:
- Tehran Univ Medical Sciences, Tehran
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TorlakTY - JOUR AU - Tomić-Spirić, Vesna AU - Dizdarević, Denisa AU - Janković, Slavenka AU - Burazer, Lidija AU - Barac, Aleksandra AU - Bolpacić, Jasna AU - Đurić, Vojislav AU - Perić-Popadić, Aleksandra AU - Aleksić, Aleksandra AU - Bogić, Mirjana PY - 2016 UR - http://intor.torlakinstitut.com/handle/123456789/474 AB - Sublingual allergen immunotherapy (SLIT) is considered to be safer and more convenient than subcutaneus immunotherapy. SLIT trials with house dust mites involving patients with allergic rhinitis (AR) and asthma reported discordant results. The aim of the study was to investigate the clinical efficacy and safety of SLIT with Dermatophagoides pteronyssinus (D.pt) extract produced in Serbia and patient's satisfaction through open-label trial. Adult patients with allergic rhinitis were randomized into two groups: one received drugs and SLIT, while other received only drugs. Symptom score (SS), medication score (MS) and cumulative score (CS), skin prick tests (SPT) and serum level of D. pt specific IgE were assessed. One year after, the patients were re-evaluated. In total, 61 patients were enrolled in the study, but 52 of them were analyzed at the end of the year. CS (29.3%, p lt 0.001) and MS (54.3%, p lt 0.05) reduced significantly in the SLIT group. There was a significant improvement of MS and CS in the SLIT compared to control group (p lt 0.001 and p lt 0.05 respectively). There was no significant improvement of SS as well as specific slgE. Patients in the SLIT group were more satisfied with treatment (p lt 0.001). The incidence of mild adverse reaction was 38.4%. Specific lgG was not done. One year SLIT with D. pt extract was clinically efficient treatment in AR patients. PB - Tehran Univ Medical Sciences, Tehran T2 - Iranian Journal of Allergy, Asthma and Immunology T1 - Efficacy of Sublingual Immunotherapy with Dermatophagoides Pteronyssinus: A Real-life Study EP - 121 IS - 2 SP - 112 VL - 15 UR - https://hdl.handle.net/21.15107/rcub_intor_474 ER -
@article{ author = "Tomić-Spirić, Vesna and Dizdarević, Denisa and Janković, Slavenka and Burazer, Lidija and Barac, Aleksandra and Bolpacić, Jasna and Đurić, Vojislav and Perić-Popadić, Aleksandra and Aleksić, Aleksandra and Bogić, Mirjana", year = "2016", abstract = "Sublingual allergen immunotherapy (SLIT) is considered to be safer and more convenient than subcutaneus immunotherapy. SLIT trials with house dust mites involving patients with allergic rhinitis (AR) and asthma reported discordant results. The aim of the study was to investigate the clinical efficacy and safety of SLIT with Dermatophagoides pteronyssinus (D.pt) extract produced in Serbia and patient's satisfaction through open-label trial. Adult patients with allergic rhinitis were randomized into two groups: one received drugs and SLIT, while other received only drugs. Symptom score (SS), medication score (MS) and cumulative score (CS), skin prick tests (SPT) and serum level of D. pt specific IgE were assessed. One year after, the patients were re-evaluated. In total, 61 patients were enrolled in the study, but 52 of them were analyzed at the end of the year. CS (29.3%, p lt 0.001) and MS (54.3%, p lt 0.05) reduced significantly in the SLIT group. There was a significant improvement of MS and CS in the SLIT compared to control group (p lt 0.001 and p lt 0.05 respectively). There was no significant improvement of SS as well as specific slgE. Patients in the SLIT group were more satisfied with treatment (p lt 0.001). The incidence of mild adverse reaction was 38.4%. Specific lgG was not done. One year SLIT with D. pt extract was clinically efficient treatment in AR patients.", publisher = "Tehran Univ Medical Sciences, Tehran", journal = "Iranian Journal of Allergy, Asthma and Immunology", title = "Efficacy of Sublingual Immunotherapy with Dermatophagoides Pteronyssinus: A Real-life Study", pages = "121-112", number = "2", volume = "15", url = "https://hdl.handle.net/21.15107/rcub_intor_474" }
Tomić-Spirić, V., Dizdarević, D., Janković, S., Burazer, L., Barac, A., Bolpacić, J., Đurić, V., Perić-Popadić, A., Aleksić, A.,& Bogić, M.. (2016). Efficacy of Sublingual Immunotherapy with Dermatophagoides Pteronyssinus: A Real-life Study. in Iranian Journal of Allergy, Asthma and Immunology Tehran Univ Medical Sciences, Tehran., 15(2), 112-121. https://hdl.handle.net/21.15107/rcub_intor_474
Tomić-Spirić V, Dizdarević D, Janković S, Burazer L, Barac A, Bolpacić J, Đurić V, Perić-Popadić A, Aleksić A, Bogić M. Efficacy of Sublingual Immunotherapy with Dermatophagoides Pteronyssinus: A Real-life Study. in Iranian Journal of Allergy, Asthma and Immunology. 2016;15(2):112-121. https://hdl.handle.net/21.15107/rcub_intor_474 .
Tomić-Spirić, Vesna, Dizdarević, Denisa, Janković, Slavenka, Burazer, Lidija, Barac, Aleksandra, Bolpacić, Jasna, Đurić, Vojislav, Perić-Popadić, Aleksandra, Aleksić, Aleksandra, Bogić, Mirjana, "Efficacy of Sublingual Immunotherapy with Dermatophagoides Pteronyssinus: A Real-life Study" in Iranian Journal of Allergy, Asthma and Immunology, 15, no. 2 (2016):112-121, https://hdl.handle.net/21.15107/rcub_intor_474 .