Autoantibody response and pregnancy-related pathology induced by combined LPS and tetanus toxoid hyperimmunization in BALB/c and C57BL/6 mice
Само за регистроване кориснике
2015
Аутори
Petrušić, VladimirTodorović, Nevena
Živković, Irena
Dimitrijević, Rajna
Muhandes, Lina
Rajnpreht, Irena
Dimitrijević, Ljiljana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Recent data concerning antiphospholipid syndrome (APS) induction have shown that beta(2)-glycoprotein I (beta(2)GPI) binds lipopolysaccharide (LPS), which results in conformational changes, exposition of a cryptic epitope and possible pathological anti-beta(2)GPI antibody production. In order to investigate the effects of LPS on the induction of APS-related pathology, we performed hyperimmunization of BALB/c and C57BL/6 mice with LPS, alone or in combination with tetanus toxoid (TTd), a protein structurally similar to beta(2)GPI. We report that, although high affinity pathological anti-beta(2)GPI antibodies were produced in all groups of animals, the reproductive pathology was recorded only in mice that received both LPS and TTd, implying on the important roles of both infections and molecular mimicry in APS pathogenesis. Moreover, APS-related reproductive pathology was more pronounced in BALB/c (lowered fertility and fecundity) than C57BL/6 mice (lowered fecundity), which correlated w...ell with the disruption in natural antibody network observed in BALB/c mouse strain.
Кључне речи:
beta(2)-glycoprotein I / antiphospholipid syndrome / fertility / molecular mimicry / natural antibodiesИзвор:
Autoimmunity, 2015, 48, 2, 87-99Издавач:
- Taylor & Francis Ltd, Abingdon
Финансирање / пројекти:
- Алергени, антитела, ензими и мали физиолошки значајни молекули: дизајн, структура, функција и значај (RS-172049)
- Ministry of Education, Science and Technological Development of the Republic of Serbia 41021.
DOI: 10.3109/08916934.2014.961061
ISSN: 0891-6934
PubMed: 25430703
WoS: 000351610300004
Scopus: 2-s2.0-84924975517
Институција/група
TorlakTY - JOUR AU - Petrušić, Vladimir AU - Todorović, Nevena AU - Živković, Irena AU - Dimitrijević, Rajna AU - Muhandes, Lina AU - Rajnpreht, Irena AU - Dimitrijević, Ljiljana PY - 2015 UR - http://intor.torlakinstitut.com/handle/123456789/446 AB - Recent data concerning antiphospholipid syndrome (APS) induction have shown that beta(2)-glycoprotein I (beta(2)GPI) binds lipopolysaccharide (LPS), which results in conformational changes, exposition of a cryptic epitope and possible pathological anti-beta(2)GPI antibody production. In order to investigate the effects of LPS on the induction of APS-related pathology, we performed hyperimmunization of BALB/c and C57BL/6 mice with LPS, alone or in combination with tetanus toxoid (TTd), a protein structurally similar to beta(2)GPI. We report that, although high affinity pathological anti-beta(2)GPI antibodies were produced in all groups of animals, the reproductive pathology was recorded only in mice that received both LPS and TTd, implying on the important roles of both infections and molecular mimicry in APS pathogenesis. Moreover, APS-related reproductive pathology was more pronounced in BALB/c (lowered fertility and fecundity) than C57BL/6 mice (lowered fecundity), which correlated well with the disruption in natural antibody network observed in BALB/c mouse strain. PB - Taylor & Francis Ltd, Abingdon T2 - Autoimmunity T1 - Autoantibody response and pregnancy-related pathology induced by combined LPS and tetanus toxoid hyperimmunization in BALB/c and C57BL/6 mice EP - 99 IS - 2 SP - 87 VL - 48 DO - 10.3109/08916934.2014.961061 ER -
@article{ author = "Petrušić, Vladimir and Todorović, Nevena and Živković, Irena and Dimitrijević, Rajna and Muhandes, Lina and Rajnpreht, Irena and Dimitrijević, Ljiljana", year = "2015", abstract = "Recent data concerning antiphospholipid syndrome (APS) induction have shown that beta(2)-glycoprotein I (beta(2)GPI) binds lipopolysaccharide (LPS), which results in conformational changes, exposition of a cryptic epitope and possible pathological anti-beta(2)GPI antibody production. In order to investigate the effects of LPS on the induction of APS-related pathology, we performed hyperimmunization of BALB/c and C57BL/6 mice with LPS, alone or in combination with tetanus toxoid (TTd), a protein structurally similar to beta(2)GPI. We report that, although high affinity pathological anti-beta(2)GPI antibodies were produced in all groups of animals, the reproductive pathology was recorded only in mice that received both LPS and TTd, implying on the important roles of both infections and molecular mimicry in APS pathogenesis. Moreover, APS-related reproductive pathology was more pronounced in BALB/c (lowered fertility and fecundity) than C57BL/6 mice (lowered fecundity), which correlated well with the disruption in natural antibody network observed in BALB/c mouse strain.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Autoimmunity", title = "Autoantibody response and pregnancy-related pathology induced by combined LPS and tetanus toxoid hyperimmunization in BALB/c and C57BL/6 mice", pages = "99-87", number = "2", volume = "48", doi = "10.3109/08916934.2014.961061" }
Petrušić, V., Todorović, N., Živković, I., Dimitrijević, R., Muhandes, L., Rajnpreht, I.,& Dimitrijević, L.. (2015). Autoantibody response and pregnancy-related pathology induced by combined LPS and tetanus toxoid hyperimmunization in BALB/c and C57BL/6 mice. in Autoimmunity Taylor & Francis Ltd, Abingdon., 48(2), 87-99. https://doi.org/10.3109/08916934.2014.961061
Petrušić V, Todorović N, Živković I, Dimitrijević R, Muhandes L, Rajnpreht I, Dimitrijević L. Autoantibody response and pregnancy-related pathology induced by combined LPS and tetanus toxoid hyperimmunization in BALB/c and C57BL/6 mice. in Autoimmunity. 2015;48(2):87-99. doi:10.3109/08916934.2014.961061 .
Petrušić, Vladimir, Todorović, Nevena, Živković, Irena, Dimitrijević, Rajna, Muhandes, Lina, Rajnpreht, Irena, Dimitrijević, Ljiljana, "Autoantibody response and pregnancy-related pathology induced by combined LPS and tetanus toxoid hyperimmunization in BALB/c and C57BL/6 mice" in Autoimmunity, 48, no. 2 (2015):87-99, https://doi.org/10.3109/08916934.2014.961061 . .