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dc.creatorStanojević, Stanislava
dc.creatorKuštrimović, Nataša
dc.creatorMitić, Katarina
dc.creatorVujić, Vesna
dc.creatorDimitrijević, Mirjana
dc.date.accessioned2021-02-18T10:44:07Z
dc.date.available2021-02-18T10:44:07Z
dc.date.issued2015
dc.identifier.issn0360-3997
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/424
dc.description.abstractThis study investigated a putative contribution of mast cells and C-sensory fibers to differences in the development of inflammatory edema following the injection of concanavalin A (Con A) into the hind paws of Dark Agouti (DA) and Albino Oxford (AO) rats. The treatment of adult rats with mast cell-depletor compound 48/80 and neonatal depletion of C-sensory fibers independently revealed that leukocyte composition of the inflamed paws and lymph nodes during local inflammatory response to Con A was generally regulated in a similar way in DA and AO rat strains. However, in DA and AO rats, the decrease and the increase of Con A-induced plasma extravasation were associated with mast cell depletion and activation, respectively, whereas neonatal capsaicin treatment activated dermal mast cells and potentiated inflammatory plasma extravasation only in adult rats of DA strain. Hence, strain differences in Emphasis Type="Strikethrough" the development of the inflammatory response to Con A are probably controlled by the differences in the interplay between mast cells and C-sensory fibers in DA and AO rats.en
dc.publisherSpringer/Plenum Publishers, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsrestrictedAccess
dc.sourceInflammation
dc.subjectconcanavalin A (Con A)en
dc.subjectpaw edemaen
dc.subjectmast cellsen
dc.subjectC-sensory fibersen
dc.subjectDark Agouti (DA) and Albino Oxford (AO) rat strainsen
dc.titleRole of Mast Cells and C-Sensory Fibers in Concanavalin A-Induced Paw Edema in Two Rat Strainsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage1449
dc.citation.issue4
dc.citation.other38(4): 1434-1449
dc.citation.rankM22
dc.citation.spage1434
dc.citation.volume38
dc.identifier.doi10.1007/s10753-015-0118-0
dc.identifier.pmid25619815
dc.identifier.scopus2-s2.0-84937253005
dc.identifier.wos000357666000007
dc.type.versionpublishedVersion


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