Role of Mast Cells and C-Sensory Fibers in Concanavalin A-Induced Paw Edema in Two Rat Strains
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2015
Authors
Stanojević, StanislavaKuštrimović, Nataša
Mitić, Katarina
Vujić, Vesna
Dimitrijević, Mirjana
Article (Published version)
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This study investigated a putative contribution of mast cells and C-sensory fibers to differences in the development of inflammatory edema following the injection of concanavalin A (Con A) into the hind paws of Dark Agouti (DA) and Albino Oxford (AO) rats. The treatment of adult rats with mast cell-depletor compound 48/80 and neonatal depletion of C-sensory fibers independently revealed that leukocyte composition of the inflamed paws and lymph nodes during local inflammatory response to Con A was generally regulated in a similar way in DA and AO rat strains. However, in DA and AO rats, the decrease and the increase of Con A-induced plasma extravasation were associated with mast cell depletion and activation, respectively, whereas neonatal capsaicin treatment activated dermal mast cells and potentiated inflammatory plasma extravasation only in adult rats of DA strain. Hence, strain differences in Emphasis Type="Strikethrough" the development of the inflammatory response to Con A are pro...bably controlled by the differences in the interplay between mast cells and C-sensory fibers in DA and AO rats.
Keywords:
concanavalin A (Con A) / paw edema / mast cells / C-sensory fibers / Dark Agouti (DA) and Albino Oxford (AO) rat strainsSource:
Inflammation, 2015, 38, 4, 1434-1449Publisher:
- Springer/Plenum Publishers, New York
Funding / projects:
- Immune system plasticity during aging: Immunomodulatory capacity of oestrogens (RS-MESTD-Basic Research (BR or ON)-175050)
DOI: 10.1007/s10753-015-0118-0
ISSN: 0360-3997
PubMed: 25619815
WoS: 000357666000007
Scopus: 2-s2.0-84937253005
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TorlakTY - JOUR AU - Stanojević, Stanislava AU - Kuštrimović, Nataša AU - Mitić, Katarina AU - Vujić, Vesna AU - Dimitrijević, Mirjana PY - 2015 UR - http://intor.torlakinstitut.com/handle/123456789/424 AB - This study investigated a putative contribution of mast cells and C-sensory fibers to differences in the development of inflammatory edema following the injection of concanavalin A (Con A) into the hind paws of Dark Agouti (DA) and Albino Oxford (AO) rats. The treatment of adult rats with mast cell-depletor compound 48/80 and neonatal depletion of C-sensory fibers independently revealed that leukocyte composition of the inflamed paws and lymph nodes during local inflammatory response to Con A was generally regulated in a similar way in DA and AO rat strains. However, in DA and AO rats, the decrease and the increase of Con A-induced plasma extravasation were associated with mast cell depletion and activation, respectively, whereas neonatal capsaicin treatment activated dermal mast cells and potentiated inflammatory plasma extravasation only in adult rats of DA strain. Hence, strain differences in Emphasis Type="Strikethrough" the development of the inflammatory response to Con A are probably controlled by the differences in the interplay between mast cells and C-sensory fibers in DA and AO rats. PB - Springer/Plenum Publishers, New York T2 - Inflammation T1 - Role of Mast Cells and C-Sensory Fibers in Concanavalin A-Induced Paw Edema in Two Rat Strains EP - 1449 IS - 4 SP - 1434 VL - 38 DO - 10.1007/s10753-015-0118-0 ER -
@article{ author = "Stanojević, Stanislava and Kuštrimović, Nataša and Mitić, Katarina and Vujić, Vesna and Dimitrijević, Mirjana", year = "2015", abstract = "This study investigated a putative contribution of mast cells and C-sensory fibers to differences in the development of inflammatory edema following the injection of concanavalin A (Con A) into the hind paws of Dark Agouti (DA) and Albino Oxford (AO) rats. The treatment of adult rats with mast cell-depletor compound 48/80 and neonatal depletion of C-sensory fibers independently revealed that leukocyte composition of the inflamed paws and lymph nodes during local inflammatory response to Con A was generally regulated in a similar way in DA and AO rat strains. However, in DA and AO rats, the decrease and the increase of Con A-induced plasma extravasation were associated with mast cell depletion and activation, respectively, whereas neonatal capsaicin treatment activated dermal mast cells and potentiated inflammatory plasma extravasation only in adult rats of DA strain. Hence, strain differences in Emphasis Type="Strikethrough" the development of the inflammatory response to Con A are probably controlled by the differences in the interplay between mast cells and C-sensory fibers in DA and AO rats.", publisher = "Springer/Plenum Publishers, New York", journal = "Inflammation", title = "Role of Mast Cells and C-Sensory Fibers in Concanavalin A-Induced Paw Edema in Two Rat Strains", pages = "1449-1434", number = "4", volume = "38", doi = "10.1007/s10753-015-0118-0" }
Stanojević, S., Kuštrimović, N., Mitić, K., Vujić, V.,& Dimitrijević, M.. (2015). Role of Mast Cells and C-Sensory Fibers in Concanavalin A-Induced Paw Edema in Two Rat Strains. in Inflammation Springer/Plenum Publishers, New York., 38(4), 1434-1449. https://doi.org/10.1007/s10753-015-0118-0
Stanojević S, Kuštrimović N, Mitić K, Vujić V, Dimitrijević M. Role of Mast Cells and C-Sensory Fibers in Concanavalin A-Induced Paw Edema in Two Rat Strains. in Inflammation. 2015;38(4):1434-1449. doi:10.1007/s10753-015-0118-0 .
Stanojević, Stanislava, Kuštrimović, Nataša, Mitić, Katarina, Vujić, Vesna, Dimitrijević, Mirjana, "Role of Mast Cells and C-Sensory Fibers in Concanavalin A-Induced Paw Edema in Two Rat Strains" in Inflammation, 38, no. 4 (2015):1434-1449, https://doi.org/10.1007/s10753-015-0118-0 . .