Influenza vaccine and learning in C57BL mice with an acute experimental autoimmune encephalomyelitis
Само за регистроване кориснике
2014
Аутори
Kosanović, DejanaStojković, Aleksandra
Maslovarić, Irina
Vukov, Natasa
Jovanova-Nešić, Katica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Literature data suggest possible link between influenza vaccination and development of autoimmune processes. Therefore, the aim of the study was to investigate the effect of influenza vaccination on spatial learning in mice with experimental autoimmune encephalomyelitis (EAE). EAE was induced in eight-week-old C57BL/6J female mice by subcutaneous immunization (MOG(35-55) in complete Freund's adjuvant) and Pertussis vaccine injected intraperitoneally. Mice were vaccinated with influenza vaccine three days before MOG immunization. The hippocampal-dependent spatial learning test, Morris Water Maze test (MWM), was performed before and after EAE induction. Significant difference (P lt 0.05) in the time for completing the Morris Water Maze task was found between mice with mild clinical signs of EAE when compared to other mice. However no significant difference was observed between mice with EAE and mice with EAE that were vaccinated with influenza vaccine. Hippocampal tissue lesions in EAE... mice are in correlation with memory impairment. Study shows no influence of influenza vaccine on progression of clinical signs of EAE, spatial learning and memory impairment.
Кључне речи:
Autoimmunity / EAE / Morris water maze / Spatial learning / Memory impairmentИзвор:
Central European Journal of Biology, 2014, 9, 3, 242-248Издавач:
- Versita, Warsaw
Финансирање / пројекти:
- Алергени, антитела, ензими и мали физиолошки значајни молекули: дизајн, структура, функција и значај (RS-MESTD-Basic Research (BR or ON)-172049)
DOI: 10.2478/s11535-013-0270-1
ISSN: 1895-104X
WoS: 000328340800002
Scopus: 2-s2.0-84890555708
Институција/група
TorlakTY - JOUR AU - Kosanović, Dejana AU - Stojković, Aleksandra AU - Maslovarić, Irina AU - Vukov, Natasa AU - Jovanova-Nešić, Katica PY - 2014 UR - http://intor.torlakinstitut.com/handle/123456789/410 AB - Literature data suggest possible link between influenza vaccination and development of autoimmune processes. Therefore, the aim of the study was to investigate the effect of influenza vaccination on spatial learning in mice with experimental autoimmune encephalomyelitis (EAE). EAE was induced in eight-week-old C57BL/6J female mice by subcutaneous immunization (MOG(35-55) in complete Freund's adjuvant) and Pertussis vaccine injected intraperitoneally. Mice were vaccinated with influenza vaccine three days before MOG immunization. The hippocampal-dependent spatial learning test, Morris Water Maze test (MWM), was performed before and after EAE induction. Significant difference (P lt 0.05) in the time for completing the Morris Water Maze task was found between mice with mild clinical signs of EAE when compared to other mice. However no significant difference was observed between mice with EAE and mice with EAE that were vaccinated with influenza vaccine. Hippocampal tissue lesions in EAE mice are in correlation with memory impairment. Study shows no influence of influenza vaccine on progression of clinical signs of EAE, spatial learning and memory impairment. PB - Versita, Warsaw T2 - Central European Journal of Biology T1 - Influenza vaccine and learning in C57BL mice with an acute experimental autoimmune encephalomyelitis EP - 248 IS - 3 SP - 242 VL - 9 DO - 10.2478/s11535-013-0270-1 ER -
@article{ author = "Kosanović, Dejana and Stojković, Aleksandra and Maslovarić, Irina and Vukov, Natasa and Jovanova-Nešić, Katica", year = "2014", abstract = "Literature data suggest possible link between influenza vaccination and development of autoimmune processes. Therefore, the aim of the study was to investigate the effect of influenza vaccination on spatial learning in mice with experimental autoimmune encephalomyelitis (EAE). EAE was induced in eight-week-old C57BL/6J female mice by subcutaneous immunization (MOG(35-55) in complete Freund's adjuvant) and Pertussis vaccine injected intraperitoneally. Mice were vaccinated with influenza vaccine three days before MOG immunization. The hippocampal-dependent spatial learning test, Morris Water Maze test (MWM), was performed before and after EAE induction. Significant difference (P lt 0.05) in the time for completing the Morris Water Maze task was found between mice with mild clinical signs of EAE when compared to other mice. However no significant difference was observed between mice with EAE and mice with EAE that were vaccinated with influenza vaccine. Hippocampal tissue lesions in EAE mice are in correlation with memory impairment. Study shows no influence of influenza vaccine on progression of clinical signs of EAE, spatial learning and memory impairment.", publisher = "Versita, Warsaw", journal = "Central European Journal of Biology", title = "Influenza vaccine and learning in C57BL mice with an acute experimental autoimmune encephalomyelitis", pages = "248-242", number = "3", volume = "9", doi = "10.2478/s11535-013-0270-1" }
Kosanović, D., Stojković, A., Maslovarić, I., Vukov, N.,& Jovanova-Nešić, K.. (2014). Influenza vaccine and learning in C57BL mice with an acute experimental autoimmune encephalomyelitis. in Central European Journal of Biology Versita, Warsaw., 9(3), 242-248. https://doi.org/10.2478/s11535-013-0270-1
Kosanović D, Stojković A, Maslovarić I, Vukov N, Jovanova-Nešić K. Influenza vaccine and learning in C57BL mice with an acute experimental autoimmune encephalomyelitis. in Central European Journal of Biology. 2014;9(3):242-248. doi:10.2478/s11535-013-0270-1 .
Kosanović, Dejana, Stojković, Aleksandra, Maslovarić, Irina, Vukov, Natasa, Jovanova-Nešić, Katica, "Influenza vaccine and learning in C57BL mice with an acute experimental autoimmune encephalomyelitis" in Central European Journal of Biology, 9, no. 3 (2014):242-248, https://doi.org/10.2478/s11535-013-0270-1 . .