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dc.creatorStojanović, Marijana
dc.creatorPetrušić, Vladimir
dc.creatorŽivković, Irena
dc.creatorInić-Kanada, Aleksandra
dc.creatorStojičević, Ivana
dc.creatorMarinković, Emilija
dc.creatorDimitrijević, Ljiljana
dc.date.accessioned2021-02-18T10:42:02Z
dc.date.available2021-02-18T10:42:02Z
dc.date.issued2013
dc.identifier.issn0257-277X
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/395
dc.description.abstractIt is known that tetanus toxoid (TTd)-hyperimmunization induces increased titer of sera beta 2-glycoprotein I (beta 2GPI)-specific antibodies (Abs) in Balb/c mice. The concentrations of such induced anti-beta 2GPI Abs as well as their pathogenic potential are strongly influenced by the context of TTd application. beta 2GPI-specific immune response is established as a part of TTd-specific immune response by molecular mimicry mechanism due to structural homology between TTd and beta 2GPI. This finding is supported by the following facts: (1) cross-reactive Abs that recognize both TTd and beta 2GPI epitopes are present in Balb/c mice sera; (2) anti-TTd Abs secretion in splenic cultures is induced after beta 2GPI stimulation and vice versa. However, analyses of (1) IL-10 production following in vitro stimulation of immunized Balb/c mice splenocytes by TTd, beta 2GPI or glutaraldehyde-treated beta 2GPI and (2) specific impact of ConA and agonists of TLR2, TLR4, and TLR9 on anti-TTd and autoreactive Abs secretion strongly imply that these two branches of the TTd-induced immune response do not use identical cell populations and are regulated in a different way. Results presented in this paper describe that structural homology between foreign and self-antigens could focus mounted autoreactive immune response toward specific self-structure, but the context of antigen application, including a history of previous immune stimulations and adjuvants applied together with the antigen, are the main factors which determine the outcome of the induced immune response.en
dc.publisherHumana Press Inc, Totowa
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172049/RS//
dc.rightsrestrictedAccess
dc.sourceImmunologic Research
dc.subjectTetanus toxoiden
dc.subjectbeta 2-Glycoprotein Ien
dc.subjectMolecular mimicryen
dc.subjectPolyclonal cell activationen
dc.titleRole of molecular mimicry and polyclonal cell activation in the induction of pathogenic beta 2-glycoprotein I-directed immune response in Balb/c mice upon hyperimmunization with tetanus toxoiden
dc.typearticle
dc.rights.licenseARR
dc.citation.epage31
dc.citation.issue1
dc.citation.other56(1): 20-31
dc.citation.rankM22
dc.citation.spage20
dc.citation.volume56
dc.identifier.doi10.1007/s12026-012-8343-1
dc.identifier.pmid22875539
dc.identifier.scopus2-s2.0-84876411640
dc.identifier.wos000317849100003
dc.type.versionpublishedVersion


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Приказ основних података о документу