Role of molecular mimicry and polyclonal cell activation in the induction of pathogenic beta 2-glycoprotein I-directed immune response in Balb/c mice upon hyperimmunization with tetanus toxoid
Samo za registrovane korisnike
2013
Autori
Stojanović, MarijanaPetrušić, Vladimir
Živković, Irena
Inić-Kanada, Aleksandra
Stojičević, Ivana
Marinković, Emilija
Dimitrijević, Ljiljana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
It is known that tetanus toxoid (TTd)-hyperimmunization induces increased titer of sera beta 2-glycoprotein I (beta 2GPI)-specific antibodies (Abs) in Balb/c mice. The concentrations of such induced anti-beta 2GPI Abs as well as their pathogenic potential are strongly influenced by the context of TTd application. beta 2GPI-specific immune response is established as a part of TTd-specific immune response by molecular mimicry mechanism due to structural homology between TTd and beta 2GPI. This finding is supported by the following facts: (1) cross-reactive Abs that recognize both TTd and beta 2GPI epitopes are present in Balb/c mice sera; (2) anti-TTd Abs secretion in splenic cultures is induced after beta 2GPI stimulation and vice versa. However, analyses of (1) IL-10 production following in vitro stimulation of immunized Balb/c mice splenocytes by TTd, beta 2GPI or glutaraldehyde-treated beta 2GPI and (2) specific impact of ConA and agonists of TLR2, TLR4, and TLR9 on anti-TTd and auto...reactive Abs secretion strongly imply that these two branches of the TTd-induced immune response do not use identical cell populations and are regulated in a different way. Results presented in this paper describe that structural homology between foreign and self-antigens could focus mounted autoreactive immune response toward specific self-structure, but the context of antigen application, including a history of previous immune stimulations and adjuvants applied together with the antigen, are the main factors which determine the outcome of the induced immune response.
Ključne reči:
Tetanus toxoid / beta 2-Glycoprotein I / Molecular mimicry / Polyclonal cell activationIzvor:
Immunologic Research, 2013, 56, 1, 20-31Izdavač:
- Humana Press Inc, Totowa
Finansiranje / projekti:
- Alergeni, antitela, enzimi i mali fiziološki značajni molekuli: dizajn, struktura, funkcija i značaj (RS-172049)
DOI: 10.1007/s12026-012-8343-1
ISSN: 0257-277X
PubMed: 22875539
WoS: 000317849100003
Scopus: 2-s2.0-84876411640
Institucija/grupa
TorlakTY - JOUR AU - Stojanović, Marijana AU - Petrušić, Vladimir AU - Živković, Irena AU - Inić-Kanada, Aleksandra AU - Stojičević, Ivana AU - Marinković, Emilija AU - Dimitrijević, Ljiljana PY - 2013 UR - http://intor.torlakinstitut.com/handle/123456789/395 AB - It is known that tetanus toxoid (TTd)-hyperimmunization induces increased titer of sera beta 2-glycoprotein I (beta 2GPI)-specific antibodies (Abs) in Balb/c mice. The concentrations of such induced anti-beta 2GPI Abs as well as their pathogenic potential are strongly influenced by the context of TTd application. beta 2GPI-specific immune response is established as a part of TTd-specific immune response by molecular mimicry mechanism due to structural homology between TTd and beta 2GPI. This finding is supported by the following facts: (1) cross-reactive Abs that recognize both TTd and beta 2GPI epitopes are present in Balb/c mice sera; (2) anti-TTd Abs secretion in splenic cultures is induced after beta 2GPI stimulation and vice versa. However, analyses of (1) IL-10 production following in vitro stimulation of immunized Balb/c mice splenocytes by TTd, beta 2GPI or glutaraldehyde-treated beta 2GPI and (2) specific impact of ConA and agonists of TLR2, TLR4, and TLR9 on anti-TTd and autoreactive Abs secretion strongly imply that these two branches of the TTd-induced immune response do not use identical cell populations and are regulated in a different way. Results presented in this paper describe that structural homology between foreign and self-antigens could focus mounted autoreactive immune response toward specific self-structure, but the context of antigen application, including a history of previous immune stimulations and adjuvants applied together with the antigen, are the main factors which determine the outcome of the induced immune response. PB - Humana Press Inc, Totowa T2 - Immunologic Research T1 - Role of molecular mimicry and polyclonal cell activation in the induction of pathogenic beta 2-glycoprotein I-directed immune response in Balb/c mice upon hyperimmunization with tetanus toxoid EP - 31 IS - 1 SP - 20 VL - 56 DO - 10.1007/s12026-012-8343-1 ER -
@article{ author = "Stojanović, Marijana and Petrušić, Vladimir and Živković, Irena and Inić-Kanada, Aleksandra and Stojičević, Ivana and Marinković, Emilija and Dimitrijević, Ljiljana", year = "2013", abstract = "It is known that tetanus toxoid (TTd)-hyperimmunization induces increased titer of sera beta 2-glycoprotein I (beta 2GPI)-specific antibodies (Abs) in Balb/c mice. The concentrations of such induced anti-beta 2GPI Abs as well as their pathogenic potential are strongly influenced by the context of TTd application. beta 2GPI-specific immune response is established as a part of TTd-specific immune response by molecular mimicry mechanism due to structural homology between TTd and beta 2GPI. This finding is supported by the following facts: (1) cross-reactive Abs that recognize both TTd and beta 2GPI epitopes are present in Balb/c mice sera; (2) anti-TTd Abs secretion in splenic cultures is induced after beta 2GPI stimulation and vice versa. However, analyses of (1) IL-10 production following in vitro stimulation of immunized Balb/c mice splenocytes by TTd, beta 2GPI or glutaraldehyde-treated beta 2GPI and (2) specific impact of ConA and agonists of TLR2, TLR4, and TLR9 on anti-TTd and autoreactive Abs secretion strongly imply that these two branches of the TTd-induced immune response do not use identical cell populations and are regulated in a different way. Results presented in this paper describe that structural homology between foreign and self-antigens could focus mounted autoreactive immune response toward specific self-structure, but the context of antigen application, including a history of previous immune stimulations and adjuvants applied together with the antigen, are the main factors which determine the outcome of the induced immune response.", publisher = "Humana Press Inc, Totowa", journal = "Immunologic Research", title = "Role of molecular mimicry and polyclonal cell activation in the induction of pathogenic beta 2-glycoprotein I-directed immune response in Balb/c mice upon hyperimmunization with tetanus toxoid", pages = "31-20", number = "1", volume = "56", doi = "10.1007/s12026-012-8343-1" }
Stojanović, M., Petrušić, V., Živković, I., Inić-Kanada, A., Stojičević, I., Marinković, E.,& Dimitrijević, L.. (2013). Role of molecular mimicry and polyclonal cell activation in the induction of pathogenic beta 2-glycoprotein I-directed immune response in Balb/c mice upon hyperimmunization with tetanus toxoid. in Immunologic Research Humana Press Inc, Totowa., 56(1), 20-31. https://doi.org/10.1007/s12026-012-8343-1
Stojanović M, Petrušić V, Živković I, Inić-Kanada A, Stojičević I, Marinković E, Dimitrijević L. Role of molecular mimicry and polyclonal cell activation in the induction of pathogenic beta 2-glycoprotein I-directed immune response in Balb/c mice upon hyperimmunization with tetanus toxoid. in Immunologic Research. 2013;56(1):20-31. doi:10.1007/s12026-012-8343-1 .
Stojanović, Marijana, Petrušić, Vladimir, Živković, Irena, Inić-Kanada, Aleksandra, Stojičević, Ivana, Marinković, Emilija, Dimitrijević, Ljiljana, "Role of molecular mimicry and polyclonal cell activation in the induction of pathogenic beta 2-glycoprotein I-directed immune response in Balb/c mice upon hyperimmunization with tetanus toxoid" in Immunologic Research, 56, no. 1 (2013):20-31, https://doi.org/10.1007/s12026-012-8343-1 . .