Show simple item record

dc.creatorŽivković, Irena
dc.creatorPetrušić, Vladimir
dc.creatorDimitrijević, Rajna
dc.creatorStojanović, Marijana
dc.creatorDimitrijević, Ljiljana
dc.date.accessioned2021-02-18T10:41:58Z
dc.date.available2021-02-18T10:41:58Z
dc.date.issued2013
dc.identifier.issn0257-277X
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/394
dc.description.abstractOne of the established animal models for autoimmune disease antiphospholipid syndrome (APS) is TTd hyperimmunization of mice. Tetanus toxoid (TTd) and plasma protein beta(2)GPI share structural homology so that immunization with TTd induces appearance of cross-reactive antibodies. In this paper, we have investigated the presence and dynamic of fluctuation of specific (anti-TTd) and auto (anti-beta(2)GPI) antibodies induced in BALB/c mice during secondary immune response after TTd immunization with alhydrogel or glycerol as adjuvants. In addition, we followed the induced reproductive pathology as a sign of autoimmune outcome. We show undoubtedly adjuvant dependance of (1) level of induced anti-TTd IgG antibodies, (2) changes in levels of low-affinity anti-beta(2)GPI IgG antibodies, and (3) change in fecundity and fertility during secondary immune response. These findings once more indicate the importance of chosen adjuvants used for successful immunization and eventual autoantibody outcome, this time associated with the processes involving low affinity, natural antibodies.en
dc.publisherHumana Press Inc, Totowa
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172049/RS//
dc.relation41021
dc.rightsrestrictedAccess
dc.sourceImmunologic Research
dc.subjectAntiphospholipid syndromeen
dc.subjectAlhydrogelen
dc.subjectSecondary responseen
dc.subjectTetanus toxoiden
dc.titleAdjuvant dependence of APS pathology-related low-affinity antibodies during secondary immune response to tetanus toxoid in BALB/c miceen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage149
dc.citation.issue1
dc.citation.other56(1): 143-149
dc.citation.rankM22
dc.citation.spage143
dc.citation.volume56
dc.identifier.doi10.1007/s12026-012-8378-3
dc.identifier.pmid23161337
dc.identifier.scopus2-s2.0-84876410886
dc.identifier.wos000317849100013
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record