Glucocorticoid-catecholamine interplay within the composite thymopoietic regulatory network
Само за регистроване кориснике
2012
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
This paper highlights the multiple putative thymic and extrathymic points of intersection and interaction between glucocorticoids (GCs) and catecholamines (CAs)-the end-point mediators of the major routes of communication between the brain and the immune system-in the context of intricate thymic T cell-developmental tuning. More specifically, we discuss in detail findings indicating that adrenal GCs can influence thymopoiesis by adjusting directly and/or indirectly (through modulation of pituitary and local ACTH synthesis) not only thymic GC synthesis, in a cell type-specific manner, but also thymic CA bioavailability (via altering CA outflow from sympathetic nerve endings and local CA synthesis), beta and alpha(1)-adrenoceptor (AR) expression, and/or AR-mediated intracellular signal transduction in thymic cells. In addition, this short review points to GC-and CA-sensitive stages along the multistep T cell-developmental journey and the possible effects of altered GC, and consequently C...A signaling, on thymopoietic efficiency.
Кључне речи:
glucocorticoids / catecholamines / beta-adrenergic receptors / rat thymus / T cell developmentИзвор:
Neuroimmunomodulation in Health and Disease I, 2012, 1261, 34-41Издавач:
- Blackwell Science Publ, Oxford
Финансирање / пројекти:
- Неуроендокрина модулација имунског одговора: улога симпато-адреномедуларног система (RS-MESTD-MPN2006-2010-145049)
- Пластичност имунског система током старења: имуномодулаторни потенцијал естрогена (RS-MESTD-Basic Research (BR or ON)-175050)
DOI: 10.1111/j.1749-6632.2012.06623.x
ISSN: 0077-8923
PubMed: 22823391
WoS: 000312537900006
Scopus: 2-s2.0-84864081722
Институција/група
TorlakTY - JOUR AU - Pilipović, Ivan AU - Radojević, Katarina AU - Perišić, Milica AU - Leposavić, Gordana PY - 2012 UR - http://intor.torlakinstitut.com/handle/123456789/347 AB - This paper highlights the multiple putative thymic and extrathymic points of intersection and interaction between glucocorticoids (GCs) and catecholamines (CAs)-the end-point mediators of the major routes of communication between the brain and the immune system-in the context of intricate thymic T cell-developmental tuning. More specifically, we discuss in detail findings indicating that adrenal GCs can influence thymopoiesis by adjusting directly and/or indirectly (through modulation of pituitary and local ACTH synthesis) not only thymic GC synthesis, in a cell type-specific manner, but also thymic CA bioavailability (via altering CA outflow from sympathetic nerve endings and local CA synthesis), beta and alpha(1)-adrenoceptor (AR) expression, and/or AR-mediated intracellular signal transduction in thymic cells. In addition, this short review points to GC-and CA-sensitive stages along the multistep T cell-developmental journey and the possible effects of altered GC, and consequently CA signaling, on thymopoietic efficiency. PB - Blackwell Science Publ, Oxford T2 - Neuroimmunomodulation in Health and Disease I T1 - Glucocorticoid-catecholamine interplay within the composite thymopoietic regulatory network EP - 41 SP - 34 VL - 1261 DO - 10.1111/j.1749-6632.2012.06623.x ER -
@article{ author = "Pilipović, Ivan and Radojević, Katarina and Perišić, Milica and Leposavić, Gordana", year = "2012", abstract = "This paper highlights the multiple putative thymic and extrathymic points of intersection and interaction between glucocorticoids (GCs) and catecholamines (CAs)-the end-point mediators of the major routes of communication between the brain and the immune system-in the context of intricate thymic T cell-developmental tuning. More specifically, we discuss in detail findings indicating that adrenal GCs can influence thymopoiesis by adjusting directly and/or indirectly (through modulation of pituitary and local ACTH synthesis) not only thymic GC synthesis, in a cell type-specific manner, but also thymic CA bioavailability (via altering CA outflow from sympathetic nerve endings and local CA synthesis), beta and alpha(1)-adrenoceptor (AR) expression, and/or AR-mediated intracellular signal transduction in thymic cells. In addition, this short review points to GC-and CA-sensitive stages along the multistep T cell-developmental journey and the possible effects of altered GC, and consequently CA signaling, on thymopoietic efficiency.", publisher = "Blackwell Science Publ, Oxford", journal = "Neuroimmunomodulation in Health and Disease I", title = "Glucocorticoid-catecholamine interplay within the composite thymopoietic regulatory network", pages = "41-34", volume = "1261", doi = "10.1111/j.1749-6632.2012.06623.x" }
Pilipović, I., Radojević, K., Perišić, M.,& Leposavić, G.. (2012). Glucocorticoid-catecholamine interplay within the composite thymopoietic regulatory network. in Neuroimmunomodulation in Health and Disease I Blackwell Science Publ, Oxford., 1261, 34-41. https://doi.org/10.1111/j.1749-6632.2012.06623.x
Pilipović I, Radojević K, Perišić M, Leposavić G. Glucocorticoid-catecholamine interplay within the composite thymopoietic regulatory network. in Neuroimmunomodulation in Health and Disease I. 2012;1261:34-41. doi:10.1111/j.1749-6632.2012.06623.x .
Pilipović, Ivan, Radojević, Katarina, Perišić, Milica, Leposavić, Gordana, "Glucocorticoid-catecholamine interplay within the composite thymopoietic regulatory network" in Neuroimmunomodulation in Health and Disease I, 1261 (2012):34-41, https://doi.org/10.1111/j.1749-6632.2012.06623.x . .