Schizophrenia and Apolipoprotein E Gene Polymorphism in Serbian Population
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2010
Authors
Kecmanović, MiljanaDobričić, Valerija
Dimitrijević, Rajna
Keckarević, Dušan
Savić-Pavićević, Dušanka
Keckarević-Marković, Milica
Ivković, Maja
Romac, Stanka
Article (Published version)
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Show full item recordAbstract
Apolipoprotein E (APOE) gene variants are associated with alterations in brain function and increased risk of Alzheimer's disease (AD) and conflicting results have been reported in schizophrenia. Our results showed no significant differences in APOE allele or genotype frequencies between the Serbian schizophrenic patients and control individuals. However, we observed a possible association between particular subtypes of schizophrenia and APOE epsilon 3/epsilon 3 genotype (p = .01221) and epsilon 4 allele showed a tendency toward positive association with responding to typical neuroleptics. APOE genotypes have no major influence on risk of schizophrenia, treatment and response to conventional antipsychotics, and age of onset in schizophrenia.
Keywords:
APOE / genotyping / neuroleptic / schizophrenia / Serbian populationSource:
International Journal of Neuroscience, 2010, 120, 7, 502-506Publisher:
- Taylor & Francis Ltd, Abingdon
Funding / projects:
- Molekularna genetika naslednih neurodegenerativnih i psihijatrijskih oboljenja (RS-MESTD-MPN2006-2010-143013)
DOI: 10.3109/00207451003765956
ISSN: 0020-7454
PubMed: 20583903
WoS: 000279487800006
Scopus: 2-s2.0-77954195637
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TorlakTY - JOUR AU - Kecmanović, Miljana AU - Dobričić, Valerija AU - Dimitrijević, Rajna AU - Keckarević, Dušan AU - Savić-Pavićević, Dušanka AU - Keckarević-Marković, Milica AU - Ivković, Maja AU - Romac, Stanka PY - 2010 UR - http://intor.torlakinstitut.com/handle/123456789/312 AB - Apolipoprotein E (APOE) gene variants are associated with alterations in brain function and increased risk of Alzheimer's disease (AD) and conflicting results have been reported in schizophrenia. Our results showed no significant differences in APOE allele or genotype frequencies between the Serbian schizophrenic patients and control individuals. However, we observed a possible association between particular subtypes of schizophrenia and APOE epsilon 3/epsilon 3 genotype (p = .01221) and epsilon 4 allele showed a tendency toward positive association with responding to typical neuroleptics. APOE genotypes have no major influence on risk of schizophrenia, treatment and response to conventional antipsychotics, and age of onset in schizophrenia. PB - Taylor & Francis Ltd, Abingdon T2 - International Journal of Neuroscience T1 - Schizophrenia and Apolipoprotein E Gene Polymorphism in Serbian Population EP - 506 IS - 7 SP - 502 VL - 120 DO - 10.3109/00207451003765956 ER -
@article{ author = "Kecmanović, Miljana and Dobričić, Valerija and Dimitrijević, Rajna and Keckarević, Dušan and Savić-Pavićević, Dušanka and Keckarević-Marković, Milica and Ivković, Maja and Romac, Stanka", year = "2010", abstract = "Apolipoprotein E (APOE) gene variants are associated with alterations in brain function and increased risk of Alzheimer's disease (AD) and conflicting results have been reported in schizophrenia. Our results showed no significant differences in APOE allele or genotype frequencies between the Serbian schizophrenic patients and control individuals. However, we observed a possible association between particular subtypes of schizophrenia and APOE epsilon 3/epsilon 3 genotype (p = .01221) and epsilon 4 allele showed a tendency toward positive association with responding to typical neuroleptics. APOE genotypes have no major influence on risk of schizophrenia, treatment and response to conventional antipsychotics, and age of onset in schizophrenia.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "International Journal of Neuroscience", title = "Schizophrenia and Apolipoprotein E Gene Polymorphism in Serbian Population", pages = "506-502", number = "7", volume = "120", doi = "10.3109/00207451003765956" }
Kecmanović, M., Dobričić, V., Dimitrijević, R., Keckarević, D., Savić-Pavićević, D., Keckarević-Marković, M., Ivković, M.,& Romac, S.. (2010). Schizophrenia and Apolipoprotein E Gene Polymorphism in Serbian Population. in International Journal of Neuroscience Taylor & Francis Ltd, Abingdon., 120(7), 502-506. https://doi.org/10.3109/00207451003765956
Kecmanović M, Dobričić V, Dimitrijević R, Keckarević D, Savić-Pavićević D, Keckarević-Marković M, Ivković M, Romac S. Schizophrenia and Apolipoprotein E Gene Polymorphism in Serbian Population. in International Journal of Neuroscience. 2010;120(7):502-506. doi:10.3109/00207451003765956 .
Kecmanović, Miljana, Dobričić, Valerija, Dimitrijević, Rajna, Keckarević, Dušan, Savić-Pavićević, Dušanka, Keckarević-Marković, Milica, Ivković, Maja, Romac, Stanka, "Schizophrenia and Apolipoprotein E Gene Polymorphism in Serbian Population" in International Journal of Neuroscience, 120, no. 7 (2010):502-506, https://doi.org/10.3109/00207451003765956 . .