Prikaz osnovnih podataka o dokumentu

dc.creatorPetrušić, Vladimir
dc.creatorStojanović, Marijana
dc.creatorŽivković, Irena
dc.creatorInić-Kanada, Aleksandra
dc.creatorDimitrijević, Ljiljana
dc.date.accessioned2021-02-18T10:35:05Z
dc.date.available2021-02-18T10:35:05Z
dc.date.issued2010
dc.identifier.issn0882-0139
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/295
dc.description.abstractIgM is the first antibody produced during the immune response to infection or immunization, and it can be secreted as pentamer (containing a small polypeptide, termed as J chain) or hexamer (lacking J chain). In this paper we have analyzed structural characteristics (by electrophoresis and immunoblot) and anti-bacterial specificity (by enzyme-linked immunosorbent assay) of IgM antibodies purified from female patients suffering from recurrent bacterial infections of lower urinary tract and therapeutically immunized with the mixture of heat-inactivated uropathogenic bacteria. We report on changes in the composition of IgM polymers in tested patients. The immunization induced the raise of the levels of hexamers in patients that did not respond to immunization (non-responders), while the IgM polymers remained on the pentameric level in immunization dependent responders. We propose that the composition of IgM polymers could influence the immunization outcome and should be taken in count regarding the treatment of recurrent bacterial infections.en
dc.publisherTaylor & Francis Inc, Philadelphia
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142020/RS//
dc.rightsrestrictedAccess
dc.sourceImmunological Investigations
dc.subjectRecurrent bacterial infectionsen
dc.subjectImmunizationen
dc.subjectIgMen
dc.subjectHexameren
dc.subjectPentameren
dc.titleChanges in Composition of IgM Polymers in Patients Suffering from Recurrent Urinary Bacterial Infections after Bacterial Immunization Treatmenten
dc.typearticle
dc.rights.licenseARR
dc.citation.epage795
dc.citation.issue8
dc.citation.other39(8): 781-795
dc.citation.rankM23
dc.citation.spage781
dc.citation.volume39
dc.identifier.doi10.3109/08820139.2010.497831
dc.identifier.pmid20718658
dc.identifier.scopus2-s2.0-77958190678
dc.identifier.wos000283076800001
dc.type.versionpublishedVersion


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