Changes in Composition of IgM Polymers in Patients Suffering from Recurrent Urinary Bacterial Infections after Bacterial Immunization Treatment
Samo za registrovane korisnike
2010
Autori
Petrušić, VladimirStojanović, Marijana

Živković, Irena
Inić-Kanada, Aleksandra

Dimitrijević, Ljiljana
Članak u časopisu (Objavljena verzija)

Metapodaci
Prikaz svih podataka o dokumentuApstrakt
IgM is the first antibody produced during the immune response to infection or immunization, and it can be secreted as pentamer (containing a small polypeptide, termed as J chain) or hexamer (lacking J chain). In this paper we have analyzed structural characteristics (by electrophoresis and immunoblot) and anti-bacterial specificity (by enzyme-linked immunosorbent assay) of IgM antibodies purified from female patients suffering from recurrent bacterial infections of lower urinary tract and therapeutically immunized with the mixture of heat-inactivated uropathogenic bacteria. We report on changes in the composition of IgM polymers in tested patients. The immunization induced the raise of the levels of hexamers in patients that did not respond to immunization (non-responders), while the IgM polymers remained on the pentameric level in immunization dependent responders. We propose that the composition of IgM polymers could influence the immunization outcome and should be taken in count reg...arding the treatment of recurrent bacterial infections.
Ključne reči:
Recurrent bacterial infections / Immunization / IgM / Hexamer / PentamerIzvor:
Immunological Investigations, 2010, 39, 8, 781-795Izdavač:
- Taylor & Francis Inc, Philadelphia
Finansiranje / projekti:
- Ispitivanje strukture i funkcije biološki važnih makromolekula u fiziološkim i patološkim stanjima (RS-142020)
DOI: 10.3109/08820139.2010.497831
ISSN: 0882-0139
PubMed: 20718658